DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway.

abstract：:Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...

journal_title：Oncogene

authors： Beach S,Tang H,Park S,Dhillon AS,Keller ET,Kolch W,Yeung KC

更新日期：2008-04-03 00:00:00

abstract：:The human papovaviruses BK virus (BKV) and JC virus (JCV) both encode a large-tumor (T) antigen which are highly homologous to each other as well as to simian virus 40 (SV40) large-T antigen. This high conservation of amino acid sequence has resulted in overlapping antigenicity such that immunological differentiation ...

journal_title：Oncogene

authors： Marshall J,Smith AE,Cheng SH

更新日期：1991-09-01 00:00:00

abstract：:Transcriptional silencing of antitumor genes via CpG island methylation could be a mechanism mediating prostate cancer (PCa) progression from an androgen-sensitive (AS) to an androgen-insensitive (AI) state. We have used the methylation-sensitive restriction fingerprinting (MSRF) technique to identify novel CpG-rich s...

journal_title：Oncogene

authors： Wu M,Ho SM

更新日期：2004-01-08 00:00:00

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver h...

journal_title：Oncogene

authors： Rassoulzadegan M,Courtneidge SA,Loubière R,el Baze P,Cuzin F

更新日期：1990-10-01 00:00:00

abstract：:Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...

journal_title：Oncogene

authors： Patel AS,Schechter GL,Wasilenko WJ,Somers KD

更新日期：1998-06-25 00:00:00

abstract：:TEA domain (TEAD) transcription factors are key components of the Hippo-YAP1 signaling pathway, but their functional role and regulatory mechanisms remain unclear. This study aims to comprehensively explore the expression pattern and functional role of TEAD family in gastric carcinogenesis and investigate its regulati...

journal_title：Oncogene

authors： Zhou Y,Huang T,Zhang J,Wong CC,Zhang B,Dong Y,Wu F,Tong JHM,Wu WKK,Cheng ASL,Yu J,Kang W,To KF

更新日期：2017-11-23 00:00:00

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...

journal_title：Oncogene

authors： Cras A,Darsin-Bettinger D,Balitrand N,Cassinat B,Soulié A,Toubert ME,Delva L,Chomienne C

更新日期：2007-06-07 00:00:00

abstract：:The establishment of a system for in vitro clonal development of hematopoietic cells made it possible to discover the cytokines that regulate hematopoiesis. These cytokines include colony stimulating factors and others, which interact in a network, and there is a cytokine cascade which couples growth and differentiati...

journal_title：Oncogene

authors： Lotem J,Sachs L

更新日期：2002-05-13 00:00:00

abstract：:There is an increasing interest in determining the role of ribosomal proteins (RPs) in the regulation of MDM2-p53 pathway in coordinating cellular response to stress. Herein, we report a novel regulatory role of ribosomal protein S25 (RPS25) in MDM2-mediated p53 degradation and a feedback regulation of S25 by p53. We ...

journal_title：Oncogene

authors： Zhang X,Wang W,Wang H,Wang MH,Xu W,Zhang R

更新日期：2013-05-30 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:Binding partners of the Src homology domains of Vav-1 were characterized by a two-hybrid screening of a Jurkat cell cDNA library. One of the isolated clones encoded a new protein named VIK that belongs to the Kruppel-like zinc-finger gene family. Genome mapping showed that a single gene positioned at chromosome 7q22.1...

journal_title：Oncogene

authors： Houlard M,Romero-Portillo F,Germani A,Depaux A,Regnier-Ricard F,Gisselbrecht S,Varin-Blank N

更新日期：2005-01-06 00:00:00

abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...

journal_title：Oncogene

authors： García P,Calés C

更新日期：1996-08-15 00:00:00

abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...

journal_title：Oncogene

authors： Chu Y,Chen Y,Guo H,Li M,Wang B,Shi D,Cheng X,Guan J,Wang X,Xue C,Cheng T,Shi J,Yuan W

更新日期：2020-12-01 00:00:00

abstract：:Keratinocytes undergo a dramatic phenotypic conversion during reepithelialization of skin wounds to become hyperproliferative, migratory, and invasive. This transient healing response phenotypically resembles malignant transformation of keratinocytes during squamous cell carcinoma progression. Here we present the firs...

journal_title：Oncogene

authors： Pedersen TX,Leethanakul C,Patel V,Mitola D,Lund LR,Danø K,Johnsen M,Gutkind JS,Bugge TH

更新日期：2003-06-19 00:00:00

abstract：:ATM is a member of the large phosphatidylinositol-3 kinase family and plays an important role in cellular response to DNA damage. To further define the physiological roles of ATM at the cellular level, we created an isogenic set of stable cell lines differing only in their ATM status from the chicken B cell line DT40 ...

journal_title：Oncogene

authors： Takao N,Kato H,Mori R,Morrison C,Sonada E,Sun X,Shimizu H,Yoshioka K,Takeda S,Yamamoto K

更新日期：1999-11-25 00:00:00

abstract：:TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and differentiation in primary neurons. TrkA expression in neuronal tumors also supports NGF-dependent differentiation of neuroblastomas and apoptosis of medulloblastomas. Phosphorylation of the activati...

journal_title：Oncogene

authors： Gryz EA,Meakin SO

更新日期：2000-01-20 00:00:00

abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

journal_title：Oncogene

authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

更新日期：2019-03-01 00:00:00

abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

journal_title：Oncogene

authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

更新日期：2018-10-01 00:00:00

abstract：:A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. Apart from the clinical impact, this fact also suggests (1) that the SYT-SSX fusion gene may influence molecular mechanism...

journal_title：Oncogene

authors： Xie Y,Skytting B,Nilsson G,Grimer RJ,Mangham CD,Fisher C,Shipley J,Bjerkehagen B,Myklebost O,Larsson O

更新日期：2002-08-22 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00

abstract：:In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...

journal_title：Oncogene

authors： Aouacheria A,Arnaud E,Venet S,Lalle P,Gouy M,Rigal D,Gillet G

更新日期：2001-09-13 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) has pivotal role in the degradation of extracellular matrix, and thereby enhances the invasive, proliferative and metastatic potential in cancer. Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation ...

journal_title：Oncogene

authors： Kesanakurti D,Chetty C,Dinh DH,Gujrati M,Rao JS

更新日期：2013-01-17 00:00:00

abstract：:The RAS-RAF-MEK-ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF and MEK inhibitors are available that provide survival benefits...

journal_title：Oncogene

authors： Dankner M,Rose AAN,Rajkumar S,Siegel PM,Watson IR

更新日期：2018-06-01 00:00:00

abstract：:Histone acetylation has a central role in establishing an active chromatin environment. The functional contribution of histone acetylation to chromatin transcription is accomplished by a dominant action of histone acetyltransferases over repressive histone-modifying activities at gene promoters; misregulation of these...

journal_title：Oncogene

authors： Heo K,Kim JS,Kim K,Kim H,Choi J,Yang K,An W

更新日期：2013-05-16 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00

abstract：:The trans-activator protein, tax, from the human T leukemia virus type 1 (HTLV-1) trans-activates both viral and cellular genes. It has previously been shown that granulocyte macrophage-colony stimulating factor (GM-CSF) is constitutively expressed in HTLV-1 infected cells and in cells artificially expressing tax. We ...

journal_title：Oncogene

authors： Himes SR,Coles LS,Katsikeros R,Lang RK,Shannon MF

更新日期：1993-12-01 00:00:00

abstract：:Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests...

journal_title：Oncogene

authors： van Gijn SE,Wierenga E,van den Tempel N,Kok YP,Heijink AM,Spierings DCJ,Foijer F,van Vugt MATM,Fehrmann RSN

更新日期：2019-02-01 00:00:00

abstract：:A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected in most of the mel...

journal_title：Oncogene

authors： Yang X,Hu F,Liu JA,Yu S,Cheung MPL,Liu X,Ng IO,Guan XY,Wong KKW,Sharma R,Lung HL,Jiao Y,Lee LTO,Cheung M

更新日期：2020-05-01 00:00:00