Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells.

abstract：:The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...

journal_title：Oncogene

authors： Post SM,Quintás-Cardama A,Terzian T,Smith C,Eischen CM,Lozano G

更新日期：2010-03-04 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:Cells in culture become competent to replicate in the absence of growth factor after progressing beyond the late G1 restriction point, suggesting that a set of genes expressed during G1 phase is sufficient to trigger completion of the cell cycle. However, this has not been demonstrated in an in vivo system. In this st...

journal_title：Oncogene

authors： Nelsen CJ,Hansen LK,Rickheim DG,Chen C,Stanley MW,Krek W,Albrecht JH

更新日期：2001-04-05 00:00:00

abstract：:The E2F1 transcription factor binds to sites within the promoters of a number of cell cycle regulated genes through a basic-helix-loop-helix motif (bHLH). It is shown here that the basic region of E2F1 is distinct from that of all other bHLH proteins. The center of the basic region contains a helix breaking proline-gl...

journal_title：Oncogene

authors： Jordan KL,Haas AR,Logan TJ,Hall DJ

更新日期：1994-04-01 00:00:00

abstract：:Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We set out to unco...

journal_title：Oncogene

authors： Aubry A,Pearson JD,Huang K,Livne-Bar I,Ahmad M,Jagadeesan M,Khetan V,Ketela T,Brown KR,Yu T,Lu S,Wrana JL,Moffat J,Bremner R

更新日期：2020-07-01 00:00:00

abstract：:Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...

journal_title：Oncogene

authors： Johnson J,Thijssen B,McDermott U,Garnett M,Wessels LF,Bernards R

更新日期：2016-09-15 00:00:00

abstract：:Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers with poor prognosis. Both are critical mitotic regulators, and phosphorylation of Hec1 S165 by Nek2 is required for proper chromosome segregation. Therefore, inactivation of Hec1 and Nek2 by targeting their interactio...

journal_title：Oncogene

authors： Hu CM,Zhu J,Guo XE,Chen W,Qiu XL,Ngo B,Chien R,Wang YV,Tsai CY,Wu G,Kim Y,Lopez R,Chamberlin AR,Lee EY,Lee WH

更新日期：2015-03-05 00:00:00

abstract：:RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif protein 43 (RBM43) is significantly downregulated in human tumors, and its low expression is correlated with poor prognosis in patients with HCC. Overexpression of RBM43 sup...

journal_title：Oncogene

authors： Feng H,Liu J,Qiu Y,Liu Y,Saiyin H,Liang X,Zheng F,Wang Y,Jiang D,Wang Y,Yu L,Su W,Shen S,Wu J

更新日期：2020-08-01 00:00:00

abstract：:A hallmark of plasma cells is the expression of syndecan-1, which has major functions in epithelial cells, in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells. As am...

journal_title：Oncogene

authors： Mahtouk K,Hose D,Rème T,De Vos J,Jourdan M,Moreaux J,Fiol G,Raab M,Jourdan E,Grau V,Moos M,Goldschmidt H,Baudard M,Rossi JF,Cremer FW,Klein B

更新日期：2005-05-12 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale i...

journal_title：Oncogene

authors： Chen CH,Fong LWR,Yu E,Wu R,Trott JF,Weiss RH

更新日期：2017-06-22 00:00:00

abstract：:A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism. CHTM1 localizes to mitochondria and cytosol...

journal_title：Oncogene

authors： Babbar M,Huang Y,An J,Landas SK,Sheikh MS

更新日期：2018-04-01 00:00:00

abstract：:Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) m...

journal_title：Oncogene

authors： Braunger J,Schleithoff L,Schulz AS,Kessler H,Lammers R,Ullrich A,Bartram CR,Janssen JW

更新日期：1997-06-05 00:00:00

abstract：:The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...

journal_title：Oncogene

authors： Haller BK,Bråve A,Wallgard E,Roswall P,Sunkari VG,Mattson U,Hallengärd D,Catrina SB,Hellström M,Pietras K

更新日期：2010-07-29 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00

abstract：:While studying Bim, a BH3-only proapoptotic protein, we identified an approximately 36 kDa protein, which was abundantly expressed in all five strains of primary normal human prostate (NHP) epithelial cells but significantly reduced or lost in seven prostate cancer cell lines. The approximately 36 kDa protein was subs...

journal_title：Oncogene

authors： Liu JW,Shen JJ,Tanzillo-Swarts A,Bhatia B,Maldonado CM,Person MD,Lau SS,Tang DG

更新日期：2003-03-13 00:00:00

abstract：:Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility. Our previous studies have identified that PHLPP2 participates in in...

journal_title：Oncogene

authors： Peng M,Wang J,Zhang D,Jin H,Li J,Wu XR,Huang C

更新日期：2018-10-01 00:00:00

abstract：:Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gen...

journal_title：Oncogene

authors： Lin HM,Pestell RG,Raz A,Kim HR

更新日期：2002-11-14 00:00:00

abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

journal_title：Oncogene

authors： Ferreira LM,Hebrant A,Dumont JE

更新日期：2012-09-06 00:00:00

abstract：:The chicken c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that differ in their N-termini, encoded respectively by the I54 and alpha beta exons. p68c-ets-1 equivalents are only found in birds and reptiles while p54c-ets-1 is widely conserved in vertebrates, from amphibians to mammals. Thus,...

journal_title：Oncogene

authors： Albagli O,Soudant N,Ferreira E,Dhordain P,Dewitte F,Begue A,Flourens A,Stehelin D,Leprince D

更新日期：1994-11-01 00:00:00

abstract：:The RET proto-oncogene encodes a functional receptor tyrosine kinase (Ret) for the Glial cell line Derived Neurotrophic Factor (GDNF). RET is involved in several neoplastic and non-neoplastic human diseases. Oncogenic activation of RET is detected in human papillary thyroid tumours and in multiple endocrine neoplasia ...

journal_title：Oncogene

authors： Chiariello M,Visconti R,Carlomagno F,Melillo RM,Bucci C,de Franciscis V,Fox GM,Jing S,Coso OA,Gutkind JS,Fusco A,Santoro M

更新日期：1998-05-14 00:00:00

abstract：:Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,van der Ent W,Brisac A,Irondelle M,Aubert S,Dirksen U,Bouvier C,de Pinieux G,Snaar-Jagalska E,Chavrier P,Delattre O

更新日期：2017-06-22 00:00:00

abstract：:beta-Catenin, a component of the Wnt signaling pathway, is a coactivator of human androgen receptor (hAR) transcriptional activity. Here, we show that Wnt signaling also influences androgen-mediated signaling through its ability to regulate hAR mRNA and protein in prostate cancer (PCa) cells. Three functional LEF-1/TC...

journal_title：Oncogene

authors： Yang X,Chen MW,Terry S,Vacherot F,Bemis DL,Capodice J,Kitajewski J,de la Taille A,Benson MC,Guo Y,Buttyan R

更新日期：2006-06-08 00:00:00

abstract：:Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...

journal_title：Oncogene

authors： Kang BS,French OG,Sando JJ,Hahn CS

更新日期：2000-08-31 00:00:00

abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...

journal_title：Oncogene

authors： Urano T,Furukawa K,Shiku H

更新日期：1993-05-01 00:00:00

abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

journal_title：Oncogene

authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

更新日期：2004-07-22 00:00:00

abstract：:Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...

journal_title：Oncogene

authors： Li BS,Zuo QF,Zhao YL,Xiao B,Zhuang Y,Mao XH,Wu C,Yang SM,Zeng H,Zou QM,Guo G

更新日期：2015-05-14 00:00:00

abstract：:Evidence from murine fibroblast models and human breast cancer cells indicates that c-Src and human EGF receptor (HER1) synergize to enhance neoplastic growth of mammary epithelial cells. To investigate whether interactions between c-Src and other HER family members may also play a role in breast tumor progression, we...

journal_title：Oncogene

authors： Belsches-Jablonski AP,Biscardi JS,Peavy DR,Tice DA,Romney DA,Parsons SJ

更新日期：2001-03-22 00:00:00

abstract：:We have sought to identify and isolate target genes for the zinc finger protein, EVI-1, which has been implicated in the genesis of myelogenous leukemia both in mouse and human. We have approached this with a two-step selection: we first selected for genomic fragments of mouse DNA that bind to the protein with high af...

journal_title：Oncogene

authors： Kim JH,Hui P,Yue D,Aycock J,Leclerc C,Bjoring AR,Perkins AS

更新日期：1998-09-24 00:00:00

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00