Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene.

Abstract:

:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence similarity to the extracellular (ligand-binding domain of platelet-derived growth factor receptor beta, we have designated it PRLTS (PDGF-receptor beta-like tumor suppressor). Structural rearrangement involving this gene was found in a sporadic NSCLC. In addition, somatic missense and frame-shift mutations were found in two HCCs and one CRC. These findings indicate that inactivation of the PRLTS gene may play a significant role in development of some carcinomas.

journal_name

Oncogene

journal_title

Oncogene

authors

Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

subject

Has Abstract

pub_date

1995-03-02 00:00:00

pages

891-5

issue

5

eissn

0950-9232

issn

1476-5594

journal_volume

10

pub_type

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