Metabolic reprogramming of the tumor.

Abstract:

:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a historical account on cancer metabolism research, and to try to integrate and systematize the metabolic strategies in which cancer cells engage to overcome selective pressures during their inception and evolution. Implications of this renovated view on some common concepts and in therapeutics are also discussed.

journal_name

Oncogene

journal_title

Oncogene

authors

Ferreira LM,Hebrant A,Dumont JE

doi

10.1038/onc.2011.576

subject

Has Abstract

pub_date

2012-09-06 00:00:00

pages

3999-4011

issue

36

eissn

0950-9232

issn

1476-5594

pii

onc2011576

journal_volume

31

pub_type

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