Abstract:
:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver haemangiomas and adenocarcinomas of unknown origin were also observed. In all tumours, the middle T antigen was found to be complexed with cellular tyrosine kinases. These results extend the range of tumour types associated with in vivo expression of middle T and with the subsequent deregulation of pp60c-src and related tyrosine kinases.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rassoulzadegan M,Courtneidge SA,Loubière R,el Baze P,Cuzin Fsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
1507-10issue
10eissn
0950-9232issn
1476-5594journal_volume
5pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Telomerase is a ribonucleoprotein whose activity has been detected in germline cells and in neoplastic and immortal cells. Telomerase compensates the telomere loss arising by the end replication problem by synthesizing telomeric repeats at the 3' end of the eukaryotic chromosomes. Telomerase is reactivated during canc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201327
更新日期:1997-10-02 00:00:00
abstract::The Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2)pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or NRF2 mutations occurs frequently in many cancers, suggesting that NRF2 inhibition could be a promising therapeutic strategy. However, no p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.153
更新日期:2017-09-14 00:00:00
abstract::Ret is a receptor tyrosine kinase predominantly expressed in tissue derived from the neuroectoderm and is involved in multiple endocrine neoplasia type 2A and 2B, familiar medullary thyroid carcinoma, and Hirschsprung's disease. The ligand for the receptor is still unknown. Previously, using a human epidermal growth f...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-12-07 00:00:00
abstract::A dominant negative mutant of Ras, M17 Ras, was used to study the role of Ras in receptor coupling of Raf-1 and B-Raf protein serine/threonine kinases (PSKs). We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf P...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well underst...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203057
更新日期:1999-11-18 00:00:00
abstract::Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the phosphorylation of the s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206669
更新日期:2003-07-24 00:00:00
abstract::Beta-catenin and plakoglobin are closely related armadillo family proteins with shared and distinct properties; Both are associated with cadherins in actin-containing adherens junctions. Plakoglobin is also found in desmosomes where it anchors intermediate filaments to the desmosomal plaques. Beta-catenin, on the othe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203519
更新日期:2000-04-13 00:00:00
abstract::Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic niche in the livers of Ncoa5...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1256-x
更新日期:2020-05-01 00:00:00
abstract::Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1203477
更新日期:2000-05-15 00:00:00
abstract::Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201073
更新日期:1997-05-15 00:00:00
abstract::Casitas B-lineage lymphoma (CBL) protein family functions as multifunctional adaptor proteins and E3 ubiquitin ligases that are implicated as regulators of signaling in various cell types. Recent discovery revealed mutations of proto-oncogenic CBL in the linker region and RING finger domain in human acute myeloid neop...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.18
更新日期:2012-12-13 00:00:00
abstract::Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.387
更新日期:2018-02-15 00:00:00
abstract::The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0955-7
更新日期:2019-12-01 00:00:00
abstract::The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.405
更新日期:2009-01-29 00:00:00
abstract::Previous reports have indicated that the cellular slime mold Dictyostelium discoideum possesses two ras genes (rasG and rasD) and one rap gene (rap1). All three genes are developmentally regulated, with each showing a different pattern of transcription during the Dictyostelium life cycle. To establish whether there ar...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202793
更新日期:1999-07-22 00:00:00
abstract::Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.145
更新日期:2011-10-27 00:00:00
abstract::bcl-XS, a member of the bcl-2 family, has been shown to induce and/or sensitize some cells to undergo programmed cell death, and to negate the anti-apoptotic activity of bcl-XL and bcl-2 by mechanisms which are still uncertain. To help understand these mechanisms we have established stable derivatives of the K12 rat c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202224
更新日期:1998-12-10 00:00:00
abstract::We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer da...
journal_title:Oncogene
pub_type: 杂志文章,meta分析
doi:10.1038/s41388-018-0588-2
更新日期:2019-04-01 00:00:00
abstract::Heregulins (neuregulins) are a family of proteins known to interact and activate the receptor tyrosine kinases ErbB2 in association with ErbB3 or ErbB4. Using immunofluorescence microscopy, electron microscopy autoradiography, and SDS-PAGE analysis of nuclear fractions, we show that the heregulin-beta1(1-244) isoform ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-06-06 00:00:00
abstract::p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204149
更新日期:2001-02-08 00:00:00
abstract::Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. M...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203170
更新日期:1999-12-02 00:00:00
abstract::Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.545
更新日期:2012-08-09 00:00:00
abstract::Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210296
更新日期:2007-04-02 00:00:00
abstract::Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208817
更新日期:2005-08-25 00:00:00
abstract::SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its expression in 32 su...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206588
更新日期:2003-07-24 00:00:00
abstract::TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201521
更新日期:1997-12-18 00:00:00
abstract::Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all current modalities of cancer therapy. A large set of genetic, functional and biochemical studies suggest that melanoma cells become 'bullet proof' against a variety of chemotherapeutic drugs by exploiting their intrinsic resistance...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206454
更新日期:2003-05-19 00:00:00
abstract::Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208956
更新日期:2005-12-08 00:00:00
abstract::B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203618
更新日期:2000-06-15 00:00:00