Abstract:
:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an adaptive immune response and activate cytotoxic T cells (CTLs) to eliminate glioma. In this study, our data indicated that downregulations of MHC-I and APM components expressions were associated with Wnt pathway activation in GSCs. Histone deacetylases (HDAC) inhibition improved MHC-I and APM components expressions, which could be partly reverted by Wnt pathway activation. Blocking CTLs-mediated killing decreased the anti-tumor effect of tumor lysate vaccine. The enhancement of T cells immune response resulting from HDAC inhibition was dependent on CTLs cognition on tumor antigens presented by upregulated MHC-I molecule in GSCs. These data suggest that suppression of stemness pathway may be effective for GSCs-based immunotherapy against immune-escaped tumors.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yang W,Li Y,Gao R,Xiu Z,Sun Tdoi
10.1038/s41388-019-1045-6subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1098-1111issue
5eissn
0950-9232issn
1476-5594pii
10.1038/s41388-019-1045-6journal_volume
39pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0907-2
更新日期:2019-10-01 00:00:00
abstract::We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207046
更新日期:2003-10-30 00:00:00
abstract::The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206771
更新日期:2003-09-29 00:00:00
abstract::The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.213
更新日期:2017-01-19 00:00:00
abstract::MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201421
更新日期:1997-11-13 00:00:00
abstract::The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour ce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209666
更新日期:2006-10-26 00:00:00
abstract::Cyclin D1, a putative G1 cyclin, has been implicated in cell cycle control. The human cyclin D1 gene is located on chromosome 11q13 where DNA rearrangement and amplification have been detected in several types of human cancer. Previous studies demonstrated that the cyclin D1 gene is not only rearranged or amplified bu...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204771
更新日期:2001-10-01 00:00:00
abstract::Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutag...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.192
更新日期:2017-01-12 00:00:00
abstract::Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells. Two distinct RB binding sites are present within HBP1--a high affinity binding site, mediated by an ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201243
更新日期:1997-06-05 00:00:00
abstract::Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.401
更新日期:2012-04-26 00:00:00
abstract::Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206682
更新日期:2003-09-01 00:00:00
abstract::Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell metabolism also directly influences genetic, epigenetic and signaling events associated with tumor progression. Many cancer cells are addicted to glut...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.364
更新日期:2017-04-01 00:00:00
abstract::Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.399
更新日期:2013-08-15 00:00:00
abstract::Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202290
更新日期:1999-01-14 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFalpha stimulates apoptosis, it also activates the transcription factor NF-kappa B, and studies have shown that inhibition of NF-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206262
更新日期:2003-04-03 00:00:00
abstract::Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice that contain a single mutant APC gene encoding a protein truncated at residue 716 (Apc(Δ716...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.633
更新日期:2011-06-09 00:00:00
abstract::Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208552
更新日期:2005-06-02 00:00:00
abstract::Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208688
更新日期:2005-07-28 00:00:00
abstract::A distinctive subset of renal carcinomas is associated with Xp11. 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors. We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion resulting from a t(X;17)(p1...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206686
更新日期:2003-08-14 00:00:00
abstract::p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.473
更新日期:2015-10-01 00:00:00
abstract::The product of the retinoblastoma susceptibility gene, pRb, is a negative regulator of cell growth. It functions by regulating the activity of transcription factors. Rb represses some genes by sequestering or inactivating the positive transcription factor E2F and seems to activate some others by interacting with facto...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-06-06 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0985-1
更新日期:2020-01-01 00:00:00
abstract::Hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes the potentially oncogenic HBx protein, which mainly functions as a transcriptional co-activator involving in multiple gene deregulations. However, mechanisms underlying HBx-mediated oncogenicity remain unc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204481
更新日期:2001-06-21 00:00:00
abstract::The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-10-19 00:00:00
abstract::Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.317
更新日期:2012-03-08 00:00:00
abstract::A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1202749
更新日期:1999-05-13 00:00:00
abstract::Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.300
更新日期:2010-10-21 00:00:00
abstract::Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.325
更新日期:2017-03-01 00:00:00