Abstract:
:The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for non-Hodgkin's lymphoma is more complex with a reduced incidence of primary central nervous system lymphoma, but a relatively stability in the number of patients developing systemic NHL. AIDS related NHL appears not to be markedly decreased by the introduction of HAART and it is the greatest therapeutic challenge in the area of AIDS oncology. The emphasis has now shifted to cure while maintaining vigilance regarding the unique vulnerability of HIV-infected hosts. Furthermore, also for the prolongation of the survival expectancy of these patients, other non AIDS-defining tumors, such as Hodgkin's disease, anal and head and neck, lung and testicular cancer, and melanoma have been recently reported with increased frequency in patients with HIV infection.
journal_name
Oncogenejournal_title
Oncogeneauthors
Berretta M,Cinelli R,Martellotta F,Spina M,Vaccher E,Tirelli Udoi
10.1038/sj.onc.1206771subject
Has Abstractpub_date
2003-09-29 00:00:00pages
6646-59issue
42eissn
0950-9232issn
1476-5594pii
1206771journal_volume
22pub_type
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