Abstract:
:Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human melanoma and found that androgen receptor (AR) positive melanoma patients have worse survival outcomes compared with AR-negative melanoma patients. Here we report that AR can have positive roles to increase melanoma cell invasion in multiple cell lines in vitro and a mouse model in vivo. Mechanism dissection suggest that AR increases melanoma cell invasion via modulating the MITF-AXL signals via altering the miRNA-539-3p/USP13 signaling to increase MITF protein degradation through a reduction of de-ubiquitination. Restoring MITF can reverse AR-enhanced melanoma cell invasion. Together, our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signal and targeting this newly identified signal with AR degradation enhancer ASC-J9 may help us to better suppress the melanoma metastasis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Wang Y,Ou Z,Sun Y,Yeh S,Wang X,Long J,Chang Cdoi
10.1038/onc.2016.330subject
Has Abstractpub_date
2017-03-23 00:00:00pages
1644-1654issue
12eissn
0950-9232issn
1476-5594pii
onc2016330journal_volume
36pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204112
更新日期:2001-01-25 00:00:00
abstract::We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG. We show that the corresponding gene (hpttg) is overexpressed in Jurkat cells (a human T lymphoma cell line) and in samples from patients with different kinds of hematopoietic malignancies. An...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202140
更新日期:1998-10-29 00:00:00
abstract::In previous studies examining the role of pp60c-src in cellular proliferation, we demonstrated that overexpression of wild type (wt) but not mutated c-src in C3H10T1/2 murine embryo fibroblasts resulted in a 2 to 5 fold enhancement of DNA synthesis in response to epidermal growth factor (EGF). Using phosphotyrosine an...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204082
更新日期:2000-12-27 00:00:00
abstract::Several motifs are conserved in the extracellular domain of the cloned chains of the recently described cytokine receptor superfamily. One of them, usually close to the transmembrane region, is the 'WS motif'. Its function remains unknown, but it has been recently shown that the integrity of this motif is essential fo...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Gut-enriched Krüppel-like factor (GKLF or KLF4) is a zinc finger-containing, epithelial-specific transcription factor, that functions as a suppressor of cell proliferation. We previously showed that GKLF expression is decreased in intestinal and colonic adenomas, respectively, from multiple intestinal neoplasia (Min) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204645
更新日期:2001-08-09 00:00:00
abstract::Bid, a pro-apoptotic member of the Bcl-2 family, was initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2. During apoptosis, Bid can be cleaved not only by caspase-8 during death receptor apoptotic signaling, but also by other caspases, granzyme B, calpains and cathepsins. Protease-c...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2009.47
更新日期:2008-12-01 00:00:00
abstract::Radicicol, an inhibitor of Src-family protein-tyrosine kinases, causes morphological reversion of v-src- and v-Ha-ras-transformed fibroblasts and arrest of the cell cycle at both the G1 and the G2 phases. Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cel...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201443
更新日期:1997-11-20 00:00:00
abstract::The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.3
更新日期:2016-09-01 00:00:00
abstract::EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Environmental signals in the cellular milieu such as hypoxia, growth factors, extracellular matrix (ECM), or cell-surface molecules on adjacent cells can activate signaling pathways that communicate the state of the environment to the nucleus. Several groups have evaluated gene expression or signaling pathways in resp...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204972
更新日期:2001-11-15 00:00:00
abstract::Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated ch...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.130
更新日期:2014-04-03 00:00:00
abstract::In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209437
更新日期:2006-07-06 00:00:00
abstract::Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.453
更新日期:2014-10-23 00:00:00
abstract::DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture and animal models as well as analyses of clinical specimens show that activation of numerous oncogenes and loss...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210881
更新日期:2007-12-10 00:00:00
abstract::Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance. We previously found that abnormal high expression of the Tie2 re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.103
更新日期:2009-06-18 00:00:00
abstract::Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201423
更新日期:1997-11-20 00:00:00
abstract::Osteoclasts are multinuclear bone-resorbing cells that differentiate from hematopoietic precursor cells. Prostate cancer cells frequently spread to bone and secrete soluble signaling factors to accelerate osteoclast differentiation and bone resorption. However, processes and mechanisms that govern the expression of os...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0356-3
更新日期:2018-10-01 00:00:00
abstract::An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.264
更新日期:2009-11-12 00:00:00
abstract::Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the tre...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210416
更新日期:2007-05-14 00:00:00
abstract::Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200910
更新日期:1997-02-27 00:00:00
abstract::In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo. Ectopic expression of dominant-negative mutants of the TGF-beta type II receptor or type I receptor/activin recep...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210272
更新日期:2007-07-19 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.255
更新日期:2009-11-12 00:00:00
abstract::p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expres...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206248
更新日期:2003-03-20 00:00:00
abstract::The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that tran...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.537
更新日期:2011-03-24 00:00:00
abstract::The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 1...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.322
更新日期:2013-06-27 00:00:00
abstract::Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.338
更新日期:2015-07-30 00:00:00
abstract::Ret is a receptor tyrosine kinase predominantly expressed in tissue derived from the neuroectoderm and is involved in multiple endocrine neoplasia type 2A and 2B, familiar medullary thyroid carcinoma, and Hirschsprung's disease. The ligand for the receptor is still unknown. Previously, using a human epidermal growth f...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-12-07 00:00:00
abstract::CD44 is a cell surface receptor for hyaluronate, a component of the extracellular matrix (ECM). Although CD44 has been implicated in tumor invasion and metastasis, the molecular mechanisms remain to be elucidated. Here we find that CD44 expressed in cancer cells is cleaved at the membrane-proximal region of the ectodo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202447
更新日期:1999-02-18 00:00:00