Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.

abstract：:Colorectal cancer is a major cause of cancer deaths in Western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. Cyclo-oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin synthesis during inflammation, and which is...

journal_title：Oncogene

authors： Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L

更新日期：1999-10-28 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of breast carcinoma with...

journal_title：Oncogene

authors： Kerangueven F,Eisinger F,Noguchi T,Allione F,Wargniez V,Eng C,Padberg G,Theillet C,Jacquemier J,Longy M,Sobol H,Birnbaum D

更新日期：1997-01-23 00:00:00

abstract：:Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...

journal_title：Oncogene

authors： Li BS,Zuo QF,Zhao YL,Xiao B,Zhuang Y,Mao XH,Wu C,Yang SM,Zeng H,Zou QM,Guo G

更新日期：2015-05-14 00:00:00

abstract：:Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a more aggressive or malignant type. Enhanced angiogenesis is a characteristic of malignantly transformed oligodendroglioma (m-oligodendroglioma). However, the pathogenesis...

journal_title：Oncogene

authors： Qi L,Wang ZY,Shao XR,Li M,Chen SN,Liu XQ,Yan S,Zhang B,Zhang XD,Li X,Zhao W,Pan JA,Zhao B,Zhang XD

更新日期：2020-09-01 00:00:00

abstract：:Bracken fern is the environmental co-carcinogen of BPV-4 in the induction of neoplasias of the upper alimentary canal of cattle. The flavonoid quercetin is one of the most potent and best characterised mutagens present in the fern. We have shown that transfection with BPV-4 DNA and exposure to a single dose of quercet...

journal_title：Oncogene

authors： Connolly JA,Morgan IM,Jackson ME,Campo MS

更新日期：1998-05-28 00:00:00

abstract：:Non-small cell lung carcinomas (NSCLCs) are typically resistant against apoptosis induced by standard chemotherapy. We evaluated the effects of the two potential antitumor agents of the lamellarin class on a highly apoptosis-resistant NSCLC cell line. Both the marine alkaloid lamellarin-D and its synthetic amino deriv...

journal_title：Oncogene

authors： Gallego MA,Ballot C,Kluza J,Hajji N,Martoriati A,Castéra L,Cuevas C,Formstecher P,Joseph B,Kroemer G,Bailly C,Marchetti P

更新日期：2008-03-27 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:We have utilized c-abl antibodies and an in vitro kinase assay to identify the protein products of the c-abl gene in mouse testis. Although the testis contains high levels of a unique c-abl mRNA, along with lower amounts of two c-abl mRNAs common to somatic cells, we detected only a single polypeptide of approximately...

journal_title：Oncogene

authors： Ponzetto C,Wadewitz AG,Pendergast AM,Witte ON,Wolgemuth DJ

更新日期：1989-06-01 00:00:00

abstract：:Although cyclin D1 is overexpressed in a significant number of human cancers, overexpression alone is insufficient to promote tumorigenesis. In vitro studies have revealed that inhibition of cyclin D1 nuclear export unmasks its neoplastic potential. Cyclin D1 nuclear export depends upon phosphorylation of a C-terminal...

journal_title：Oncogene

authors： Benzeno S,Lu F,Guo M,Barbash O,Zhang F,Herman JG,Klein PS,Rustgi A,Diehl JA

更新日期：2006-10-12 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...

journal_title：Oncogene

authors： Clarke P,Meintzer SM,Spalding AC,Johnson GL,Tyler KL

更新日期：2001-10-18 00:00:00

abstract：:CD44 is a cell surface receptor for hyaluronate, a component of the extracellular matrix (ECM). Although CD44 has been implicated in tumor invasion and metastasis, the molecular mechanisms remain to be elucidated. Here we find that CD44 expressed in cancer cells is cleaved at the membrane-proximal region of the ectodo...

journal_title：Oncogene

authors： Okamoto I,Kawano Y,Tsuiki H,Sasaki J,Nakao M,Matsumoto M,Suga M,Ando M,Nakajima M,Saya H

更新日期：1999-02-18 00:00:00

abstract：:It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...

journal_title：Oncogene

authors： Roy WJ Jr,Watson RH,Hitchcock A,Campbell IG

更新日期：1997-10-23 00:00:00

abstract：:Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...

journal_title：Oncogene

authors： Matteucci E,Modora S,Simone M,Desiderio MA

更新日期：2003-06-26 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...

journal_title：Oncogene

authors： Gladden AB,Woolery R,Aggarwal P,Wasik MA,Diehl JA

更新日期：2006-02-16 00:00:00

abstract：:To explore the molecular mechanisms by which retinoic acid inhibits oncogenic transformation, we have examined the effects of retinoic acid on the polyomavirus-induced transformation of rat fibroblasts. Treatment of rat F111 fibroblasts with high concentrations of retinoic acid (10(-6) M) partially inhibited the abili...

journal_title：Oncogene

authors： Talmage DA,Lackey RS

更新日期：1992-09-01 00:00:00

abstract：:Bcr-Abl oncogene is responsible for the initial phase of chronic myelogenous leukemia (CML), which is effectively treated by the Bcr-Abl inhibitor imatinib. Over time patients become resistant to treatment and progress to blast crisis, an event that is driven by additional genetic and epigenetic aberrations. Recently,...

journal_title：Oncogene

authors： Lakshmikuttyamma A,Pastural E,Takahashi N,Sawada K,Sheridan DP,DeCoteau JF,Geyer CR

更新日期：2008-06-19 00:00:00

abstract：:Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression in OPM2 and delta47 human myeloma lines led to high Akt activity toward insulin-like growth factor I (...

journal_title：Oncogene

authors： Choi Y,Zhang J,Murga C,Yu H,Koller E,Monia BP,Gutkind JS,Li W

更新日期：2002-08-08 00:00:00

abstract：:The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...

journal_title：Oncogene

authors： Farnsworth RH,Lackmann M,Achen MG,Stacker SA

更新日期：2014-07-03 00:00:00

abstract：:We studied the role of the mitogen-activated protein kinase (MAPK) pathway in the regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in breast tumor MCF-7 cells. We found that addition of a protein kinase C (PKC) activator to MCF-7 cultures prevented TRAIL-induced apoptosi...

journal_title：Oncogene

authors： Sarker M,Ruiz-Ruiz C,Robledo G,López-Rivas A

更新日期：2002-06-20 00:00:00

abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

journal_title：Oncogene

authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

更新日期：2004-07-22 00:00:00

abstract：:MSH2 and MLH1 have a central role in correcting mismatches in DNA occurring during DNA replication and have been implicated in the engagement of apoptosis induced by a number of cytotoxic anticancer agents. The function of MLH1 is not clearly defined, although it is required for mismatch repair (MMR) and engagement of...

journal_title：Oncogene

authors： Mac Partlin M,Homer E,Robinson H,McCormick CJ,Crouch DH,Durant ST,Matheson EC,Hall AG,Gillespie DA,Brown R

更新日期：2003-02-13 00:00:00

abstract：:Suppressor of cytokine signaling 1 (SOCS1) is considered as a tumor suppressor protein in hepatocellular carcinoma (HCC), but the underlying mechanisms remain unclear. Previously, we have shown that SOCS1-deficient hepatocytes displayed increased responsiveness to hepatocyte growth factor (HGF) due to enhanced signali...

journal_title：Oncogene

authors： Gui Y,Yeganeh M,Donates YC,Tobelaim WS,Chababi W,Mayhue M,Yoshimura A,Ramanathan S,Saucier C,Ilangumaran S

更新日期：2015-11-12 00:00:00

abstract：:Drosophila tumor suppressor WARTS (Wts) is an evolutionally conserved serine / threonine kinase and participates in a signaling complex that regulates both proliferation and apoptosis to ensure the proper size and shape of the fly. Human counterparts of this complex have been found to be frequently downregulated or mu...

journal_title：Oncogene

authors： Kuninaka S,Nomura M,Hirota T,Iida S,Hara T,Honda S,Kunitoku N,Sasayama T,Arima Y,Marumoto T,Koja K,Yonehara S,Saya H

更新日期：2005-08-11 00:00:00

abstract：:Birt-Hogg-Dubé syndrome (BHD) is a rare, inherited genodermatosis characterized by hair follicle hamartomas, kidney tumors and spontaneous pneumothorax. The BHD locus was mapped to chromosome 17p11.2 by linkage analysis, and germline mutations in a novel gene (BHD) were identified in a panel of BHD families. Using RNA...

journal_title：Oncogene

authors： Singh SR,Zhen W,Zheng Z,Wang H,Oh SW,Liu W,Zbar B,Schmidt LS,Hou SX

更新日期：2006-09-28 00:00:00

abstract：:Low oxygen tension (hypoxia) is a common feature of solid tumors and stimulates the expressions of a variety of genes including those related to angiogenesis, apoptosis and endoplasmic reticulum (ER) stress response. Here we show a close correlation between metastatic potential and the resistance to hypoxia- and ER st...

journal_title：Oncogene

authors： Koshikawa N,Maejima C,Miyazaki K,Nakagawara A,Takenaga K

更新日期：2006-02-09 00:00:00

abstract：:CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain and to contain at least one ankyrin-binding site in its cytoplasmic domain. In this study we have examined CD44 expression in a mouse fibroblast cell line transfected with the pl85(neu) oncogene cDNA. The results of RT-...

journal_title：Oncogene

authors： Zhu D,Bourguignon L

更新日期：1996-06-06 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of ...

journal_title：Oncogene

authors： Ito TK,Ishii G,Chiba H,Ochiai A

更新日期：2007-11-08 00:00:00

abstract：:Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...

journal_title：Oncogene

authors： Chen J,Weiss WA

更新日期：2015-01-02 00:00:00