Vascular remodeling in cancer.

abstract：:Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling and oncogenesis. Caveolin-1 is down-regulated in oncogene-transformed and tumor-derived cells. Antisense suppression of caveolin-1 or expression of a dominant negative form are sufficient for inducing cellular...

journal_title：Oncogene

authors： Fiucci G,Ravid D,Reich R,Liscovitch M

更新日期：2002-04-04 00:00:00

abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

journal_title：Oncogene

authors： Chinnadurai G

更新日期：1992-07-01 00:00:00

abstract：:We have expressed wild-type and human tumour-derived mutant p53 cDNA genes in the fission yeast Schizosaccharomyces pombe. In the case of one mutant this resulted in a growth arrest of recipient yeast cells. In contrast, wild-type p53 and three other mutant proteins tested did not block outgrowth of colonies. Human an...

journal_title：Oncogene

authors： Wagner P,Simanis V,Maimets T,Keenan E,Addison C,Brain R,Grimaldi M,Sturzbecher HW,Jenkins J

更新日期：1991-09-01 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Apoptin, a protein of the chicken anemia virus (CAV), represents a novel potential anticancer therapeutic, because it induces apoptotic death specifically in tumor but not normal cells. The cellular localization appears to be crucial for apoptin's selective toxicity. In normal cells apoptin remains in the cytoplasm, w...

journal_title：Oncogene

authors： Janssen K,Hofmann TG,Jans DA,Hay RT,Schulze-Osthoff K,Fischer U

更新日期：2007-03-08 00:00:00

abstract：:Small cell lung cancer (SCLC) invades locally and metastasizes distantly extremely early when compared with nonsmall cell lung cancer (NSCLC). The underlying molecular mechanisms, however, have not been elucidated. Accumulating evidence suggests that downregulation of several members of tetraspanins is associated with...

journal_title：Oncogene

authors： Funakoshi T,Tachibana I,Hoshida Y,Kimura H,Takeda Y,Kijima T,Nishino K,Goto H,Yoneda T,Kumagai T,Osaki T,Hayashi S,Aozasa K,Kawase I

更新日期：2003-02-06 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:Signet-ring cell carcinoma is classified in poorly differentiated adenocarcinoma with an aggressive nature and a poor prognosis. We have shown that the activation of PI 3-kinase in highly differentiated adenocarcinomas induces loss of cell-cell contact and formation of vacuoles, giving phenotypes similar to those of s...

journal_title：Oncogene

authors： Xu Q,Karouji Y,Kobayashi M,Ihara S,Konishi H,Fukui Y

更新日期：2003-08-28 00:00:00

abstract：:Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...

journal_title：Oncogene

authors： Renziehausen A,Wang H,Rao B,Weir L,Nigro CL,Lattanzio L,Merlano M,Vega-Rioja A,Del Carmen Fernandez-Carranco M,Hajji N,Matin R,Harwood C,Li S,Sim VR,O'Neill K,Evans A,Thompson A,Szlosarek P,Fleming C,Stebbing J,Pr

更新日期：2019-03-01 00:00:00

abstract：:It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...

journal_title：Oncogene

authors： Roy WJ Jr,Watson RH,Hitchcock A,Campbell IG

更新日期：1997-10-23 00:00:00

abstract：:The marine alkaloid ascididemin (ASC) was shown to exert cytotoxicity even against multidrug-resistant cancer cells. Here, we address the signaling pathways utilized by ASC to trigger apoptosis in Jurkat leukemia T cells. We show that ASC (0.5-20 microM) induces a mitochondrial pathway that requires the activation of ...

journal_title：Oncogene

authors： Dirsch VM,Kirschke SO,Estermeier M,Steffan B,Vollmar AM

更新日期：2004-02-26 00:00:00

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00

abstract：:High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in th...

journal_title：Oncogene

authors： Todd MC,Xiang RH,Garcia DK,Kerbacher KE,Moore SL,Hensel CH,Liu P,Siciliano MJ,Kok K,van den Berg A,Veldhuis P,Buys CH,Killary AM,Naylor SL

更新日期：1996-12-05 00:00:00

abstract：:Integrin α3β1 regulates adhesive interactions of cells with laminins and have a critical role in adhesion-dependent cellular responses. Here, we examined the role of α3β1-integrin in ErbB2-dependent proliferation of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM). Depletion of α3...

journal_title：Oncogene

authors： Novitskaya V,Romanska H,Kordek R,Potemski P,Kusińska R,Parsons M,Odintsova E,Berditchevski F

更新日期：2014-05-22 00:00:00

abstract：:To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...

journal_title：Oncogene

authors： St-Onge L,Bastin M

更新日期：1994-03-01 00:00:00

abstract：:Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...

journal_title：Oncogene

authors： Peng F,Wang JH,Fan WJ,Meng YT,Li MM,Li TT,Cui B,Wang HF,Zhao Y,An F,Guo T,Liu XF,Zhang L,Lv L,Lv DK,Xu LZ,Xie JJ,Lin WX,Lam EW,Xu J,Liu Q

更新日期：2018-02-22 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...

journal_title：Oncogene

authors： Totzke G,Schulze-Osthoff K,Jänicke RU

更新日期：2003-09-11 00:00:00

abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...

journal_title：Oncogene

authors： Breit TM,Wolvers-Tettero IL,van Dongen JJ

更新日期：1994-07-01 00:00:00

abstract：:Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...

journal_title：Oncogene

authors： Gallagher WM,Cairney M,Schott B,Roninson IB,Brown R

更新日期：1997-01-16 00:00:00

abstract：:Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear. In this study, we show that overexpression of connexin43 (Cx43) suppressed proliferation of human osteosarcoma U2OS cells through inhibit...

journal_title：Oncogene

authors： Zhang YW,Morita I,Ikeda M,Ma KW,Murota S

更新日期：2001-07-12 00:00:00

abstract：:Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had n...

journal_title：Oncogene

authors： Qureshi SA,Joseph CK,Rim M,Maroney A,Foster DA

更新日期：1991-06-01 00:00:00

abstract：:Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression. Primarily known as a regulator of neuronal guidance and angiogenesis, NRP1 is also expressed in multiple human malignancies, where it promotes tumor angiogenesis. However, non-angiogenic roles of NRP1 in tumor progr...

journal_title：Oncogene

authors： Tse BWC,Volpert M,Ratther E,Stylianou N,Nouri M,McGowan K,Lehman ML,McPherson SJ,Roshan-Moniri M,Butler MS,Caradec J,Gregory-Evans CY,McGovern J,Das R,Takhar M,Erho N,Alshalafa M,Davicioni E,Schaeffer EM,Jenkins RB

更新日期：2017-06-15 00:00:00

abstract：:BAG-1 is a Hsp70/Hsc70-binding protein that interacts with Bcl-2, Raf-1, steroid hormone receptors, Siah-1, and hepatocyte growth factor (HGF) receptors, implying multiple functions for the BAG-1 protein. Here, we provide evidence that gene transfer-mediated overexpression of BAG-1 markedly enhances the motility of hu...

journal_title：Oncogene

authors： Naishiro Y,Adachi M,Okuda H,Yawata A,Mitaka T,Takayama S,Reed JC,Hinoda Y,Imai K

更新日期：1999-05-27 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:Testicular germ cell tumours are classified into two major histological subgroups, seminomas and nonseminomas. All tumours display several recurrent chromosomal aberrations, but few target genes have been identified. Previous studies have shown that genome-wide hypermethylation of CpG islands is significantly more pre...

journal_title：Oncogene

authors： Smith-Sørensen B,Lind GE,Skotheim RI,Fosså SD,Fodstad Ø,Stenwig AE,Jakobsen KS,Lothe RA

更新日期：2002-12-12 00:00:00

abstract：:Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs an...

journal_title：Oncogene

authors： Koyama-Nasu R,Nasu-Nishimura Y,Todo T,Ino Y,Saito N,Aburatani H,Funato K,Echizen K,Sugano H,Haruta R,Matsui M,Takahashi R,Manabe E,Oda T,Akiyama T

更新日期：2013-08-15 00:00:00

abstract：:Previous observations suggest expression of cyclooxygenase-2 to convey macrophage protection towards apoptotic cell death. We reasoned prostaglandin formation and in turn a cAMP increase as the underlying protective principle. Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipoph...

journal_title：Oncogene

authors： von Knethen A,Lotero A,Brüne B

更新日期：1998-07-23 00:00:00

abstract：:Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily. This subset, which also includes Fas ligand and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death...

journal_title：Oncogene

authors： Gonzalvez F,Ashkenazi A

更新日期：2010-08-26 00:00:00

abstract：:To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease proc...

journal_title：Oncogene

authors： Peng WX,Koirala P,Mo YY

更新日期：2017-10-12 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00