Abstract:
:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box, that is closely related to the Maf recognition element (MARE). We undertook an identification of Maf family genes expressed in the quail neuroretina (QNR) and we report the isolation of mafA, a gene encoding a novel member of the large Maf proteins subgroup. Expression of this gene is developmentally regulated in the neuroretina. MafA is able to bind to MARE sequence and to heterodimerize with v-Maf, MafB, Jun and Fos, but not with the small MafF and MafK proteins. Accordingly, it is able to transactivate the QR1 promoter A box. We also show that increased expression of mafA induces sustained proliferation of postmitotic QNR cells.
journal_name
Oncogenejournal_title
Oncogeneauthors
Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MPdoi
10.1038/sj.onc.1201898subject
Has Abstractpub_date
1998-07-16 00:00:00pages
247-54issue
2eissn
0950-9232issn
1476-5594journal_volume
17pub_type
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