Abstract:
:Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to Pin1. The Ser95-Pro motif of TR3 is the key site through which Pin1 enhances TR3 stability by retarding its degradation. Pin1 can also catalyze TR3 through phospho-Ser431-Pro motif, which is phosphorylated by extracellular signal-regulated kinase 2 (ERK2), resulting in enhanced TR3 transactivation. Furthermore, Pin1 not only facilitates TR3 targeting to the promoter of cyclin D2, a novel downstream target of TR3, but also promotes TR3 to recruit p300, thereby inducing cell proliferation. Importantly, we found that Pin1 is indispensable for TR3 to promote tumor growth both in vitro and in vivo. Our study thus suggests that Pin1 has an important role in cell proliferation by isomerizing TR3.
journal_name
Oncogenejournal_title
Oncogeneauthors
Chen HZ,Li L,Wang WJ,Du XD,Wen Q,He JP,Zhao BX,Li GD,Zhou W,Xia Y,Yang QY,Hew CL,Liou YC,Wu Qdoi
10.1038/onc.2011.463subject
Has Abstractpub_date
2012-06-07 00:00:00pages
2876-87issue
23eissn
0950-9232issn
1476-5594pii
onc2011463journal_volume
31pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.600
更新日期:2013-11-14 00:00:00
abstract::Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.368
更新日期:2018-02-22 00:00:00
abstract::Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210607
更新日期:2007-08-13 00:00:00
abstract::Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.325
更新日期:2008-12-04 00:00:00
abstract::The tumor-stroma crosstalk is a dynamic process fundamental in tumor development. In hepatocellular carcinoma (HCC), the progression of malignant hepatocytes frequently depends on transforming growth factor (TGF)-beta provided by stromal cells. TGF-beta induces an epithelial to mesenchymal transition (EMT) of oncogeni...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.253
更新日期:2009-11-12 00:00:00
abstract::Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0039-5
更新日期:2018-03-01 00:00:00
abstract::We have previously shown that each of four activated oncogenes (c-myc, neu, ras, and int-2) can serve as transgenic initiators of morphologically distinct adenocarcinomas of the murine mammary gland. Since abnormalities of these oncogenes are found frequently in human breast cancers, such differences are of particular...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Wild-type human p53 protein is able to self-associate and consists predominantly of homotetramers in solution. In earlier work we identified the protein sequence motifs involved in p53 quaternary structure and showed that while monomeric p53 protein retains tumour suppressor function, monomeric tumour mutant p53 lacks...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-03-07 00:00:00
abstract::Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory co...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206813
更新日期:2003-09-29 00:00:00
abstract::Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::The mitochondrial apoptosis pathway mediates cell death through the release of various pro-apoptotic factors including cytochrome c and Smac, the second mitochondrial activator of caspases, into the cytosol. Smac was shown previously to inhibit IAP proteins and to facilitate initiation of the caspase cascade upon cyto...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207594
更新日期:2004-06-03 00:00:00
abstract::We have evaluated the transcriptional activation of a human p21 promoter reporter construct by transfection of BRCA1 expression constructs into tumorigenic and nontumorigenic human breast cell lines. Two cell lines with wildtype p53 (MCF-7 and MCF10A) demonstrated transcriptional activation of the p21 promoter by full...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204025
更新日期:2000-12-14 00:00:00
abstract::Treatment of mouse (12)1/CA cells with adriamycin or irradiation with U.V.C. induces p53-dependent transcription of a beta-galactosidase reporter and the endogenous p21/Waf1/Cip1 gene. Despite the induction of Waf1, the cells arrest only transiently in G1 or G2, then resume growth and eventually undergo apoptosis. In ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201104
更新日期:1997-05-29 00:00:00
abstract::A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207723
更新日期:2004-07-15 00:00:00
abstract::Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of beta-catenin. We here demonstrate that a functional crosstalk between Met and beta-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209859
更新日期:2007-02-15 00:00:00
abstract::RNA polymerase (pol) III synthesizes a range of essential products, including tRNA, 5S rRNA and 7SL RNA, which are required for protein synthesis and trafficking. High rates of pol III transcription are necessary for cells to sustain growth. A wide range of transformed and tumour cell types have been shown to express ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207547
更新日期:2004-04-19 00:00:00
abstract::The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been obscure for long time, being ARF a relatively stable protein. Recently, it has been described that its degradation depends, a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210313
更新日期:2007-08-02 00:00:00
abstract::Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits J...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208470
更新日期:2005-05-05 00:00:00
abstract::The A-myb gene belongs to the family of the c-myb proto-oncogene. We report here the cloning from a B lymphocyte cDNA library of the previously missing 3' half of the human A-myb cDNA, thus closing the previously still incomplete open reading frame. Analysis of the homologies between the different myb proteins reveals...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Our previous work with primary bovine fibroblasts demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 and G2/M, in correlation with p53 activation. The expression of bovine papillomavirus type 4 (BPV-4) E7 overcame this arrest and lead to the d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206848
更新日期:2003-08-21 00:00:00
abstract::The function of the class III histone deacetylase, Sir2, in promoting lifespan extension is well established in small model organisms. By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-associated diseases. We have used SirT1-null mice to study th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.147
更新日期:2009-08-13 00:00:00
abstract::Radioresistance becomes the major obstacle to reduce tumor recurrence and improve prognosis in the treatment of esophageal squamous cell carcinoma (ESCC). Thus new strategies for radioresistant ESCC are urgently needed. Herein, we reported that tribbles pseudokinase 3 (TRIB3) serves as a key regulator of radioresistan...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1245-0
更新日期:2020-04-01 00:00:00
abstract::Post-translational acetylation of lysines is most extensively studied in histones, but this modification is also found in many other proteins and is implicated in a wide range of biological processes in both the cell nucleus and the cytoplasm. Like phosphorylation, acetylation patterns and levels are often altered in ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2014.453
更新日期:2015-09-17 00:00:00
abstract::To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204196
更新日期:2001-03-08 00:00:00
abstract::Lysyl oxidase (LOX) is a multifunctional protein required for normal collagen and elastin biosynthesis and maturation. In addition, LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro-LOX has tumor-suppressor activity, while the active enzyme promotes metastasis. In pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.147
更新日期:2015-04-09 00:00:00
abstract::In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-08-15 00:00:00
abstract::Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202373
更新日期:1999-01-21 00:00:00
abstract::Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1362-9
更新日期:2020-07-01 00:00:00