Abstract:
:The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer. The mechanisms that regulate alternative reading frame (ARF) turnover have been obscure for long time, being ARF a relatively stable protein. Recently, it has been described that its degradation depends, at least in part, on the proteasome and that it can be subjected to N-terminal ubiquitination. We have previously reported that ARF protein levels are regulated by TBP-1 (Tat-Binding Protein 1), a multifunctional protein, component of the regulatory subunit of the proteasome, involved in different cellular processes. Here we demonstrate that the stabilization effect exerted by TBP-1 requires an intact N-terminal 39 amino acids in ARF and occurs independently from N-terminal ubiquitination of the protein. Furthermore, we observed that ARF can be degraded in vitro by the 20S proteasome, in the absence of ubiquitination and this effect can be counteracted by TBP-1. These observations seem relevant in the comprehension of the regulation of ARF metabolism as, among the plethora of cellular ARF's interactors already identified, only NPM/B23 and TBP-1 appear to be involved in the control of ARF intracellular levels.
journal_name
Oncogenejournal_title
Oncogeneauthors
Pollice A,Sepe M,Villella VR,Tolino F,Vivo M,Calabrò V,La Mantia Gdoi
10.1038/sj.onc.1210313subject
Has Abstractpub_date
2007-08-02 00:00:00pages
5154-62issue
35eissn
0950-9232issn
1476-5594pii
1210313journal_volume
26pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Due to its high proclivity to metastasize, and despite the recent development of targeted and immune therapy strategies, melanoma is still the deadliest form of skin cancer. Therefore, understanding the molecular mechanisms underlying melanoma invasion remains crucial. We previously characterized Tspan8 for its abilit...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0691-z
更新日期:2019-05-01 00:00:00
abstract::Neuroblastoma (Nb) is a malignancy of the sympathetic nervous system which affects children in their first decade. It is the most common extra-cranial solid tumor in children with an incidence of approximately 1 in 8-10 000 live births annually and accounts for approximately 10% of all children's cancers. Ganglioneuro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205734
更新日期:2002-08-29 00:00:00
abstract::We have previously demonstrated the existence of a melanoma tumor suppressor gene(s) on the long arm of chromosome 11 through suppression of tumorigenicity assays. Although loss of heterozygosity studies also support this finding, only a large critical region (44 cM) has been identified to date on 11q22-25. To further...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202664
更新日期:1999-05-20 00:00:00
abstract::Centrosome hyperamplification and the consequential mitotic defects contribute to chromosome instability in cancers. Loss or mutational inactivation of p53 has been shown to induce chromosome instability through centrosome hyperamplification. It has recently been found that Cdk2-cyclin E is involved in the initiation ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203460
更新日期:2000-03-23 00:00:00
abstract::Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.28
更新日期:2010-05-06 00:00:00
abstract::Microsatellite-stable, near-diploid (MSI-CIN-) colorectal carcinomas have been reported, but it is not clear as to whether these tumours form a discrete group or represent one end of the distribution of MSI-CIN+ cancers. In order to address this question, we screened 23 MSI-CIN- colorectal cancers for gains and losses...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208194
更新日期:2005-01-06 00:00:00
abstract::Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown mechanism in poor prognosis hepatocellular carcinoma (HCC), often associated with chronic hepatitis B virus (HBV) infection. Herein, we investigated the mechanism of SALL4 re-expression in HBV-related HCCs. We p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.399
更新日期:2017-04-27 00:00:00
abstract::D-type cyclins are important cell cycle regulators that promote cellular proliferation in response to growth factors by inactivation of the retinoblastoma protein (Rb). Cyclin D1 has been shown to be overexpressed in several cancer types and to act as an oncogene in breast cancers. As D-type cyclins are rate limiting ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202511
更新日期:1999-03-18 00:00:00
abstract::Human Papillomavirus (HPV) type 16 is the most frequently detected HPV in cervical cancer. Although epidemiologic and experimental evidence indicates a prominent role for HPV infection in the development of this disease, other factors are also involved. Altered expression of the ets family transcription factors erg an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201058
更新日期:1997-05-08 00:00:00
abstract::Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ub...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.302
更新日期:2017-03-01 00:00:00
abstract::The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.153
更新日期:2011-10-20 00:00:00
abstract::The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known abou...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So far, no clear link has been established ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0789-3
更新日期:2019-06-01 00:00:00
abstract::The long-term cellular response to DNA damage is controlled by the tumor suppressor p53. It results in cell-cycle arrest followed by DNA repair and, depending on the degree of damage inflicted, premature senescence or apoptotic cell death. Here we show that in normal diploid fibroblasts the ubiquitin ligase anaphase-p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.99
更新日期:2010-06-17 00:00:00
abstract::In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202165
更新日期:1998-11-19 00:00:00
abstract::The family of tripartite-motif (TRIM) proteins are involved in diverse cellular processes, but are often characterized by critical protein-protein interactions necessary for their function. TRIM16 is induced in different cancer types, when the cancer cell is forced to proceed down a differentiation pathway. We have id...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.340
更新日期:2010-11-18 00:00:00
abstract::Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we report that HBV leads to liver fibrosis and hepatocarcinogenesis through miR-30e targeting P4HA2. HBV transgenic ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.291
更新日期:2017-12-14 00:00:00
abstract::The marine alkaloid ascididemin (ASC) was shown to exert cytotoxicity even against multidrug-resistant cancer cells. Here, we address the signaling pathways utilized by ASC to trigger apoptosis in Jurkat leukemia T cells. We show that ASC (0.5-20 microM) induces a mitochondrial pathway that requires the activation of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207281
更新日期:2004-02-26 00:00:00
abstract::Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.22
更新日期:2011-06-30 00:00:00
abstract::p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208852
更新日期:2005-11-03 00:00:00
abstract::Metastasis is the chief cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metasta...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.213
更新日期:2010-08-12 00:00:00
abstract::All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207940
更新日期:2004-09-20 00:00:00
abstract::Bloom syndrome and ataxia-telangiectasia are autosomal recessive human disorders characterized by immunodeficiency, genome instability and predisposition to develop cancer. Recent data reveal that the products of these two genes, BLM and ATM, interact and function together in recognizing abnormal DNA structures. To in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207276
更新日期:2004-02-26 00:00:00
abstract::Gut-enriched Krüppel-like factor (GKLF or KLF4) is a zinc finger-containing, epithelial-specific transcription factor, that functions as a suppressor of cell proliferation. We previously showed that GKLF expression is decreased in intestinal and colonic adenomas, respectively, from multiple intestinal neoplasia (Min) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204645
更新日期:2001-08-09 00:00:00
abstract::Mdm2, a regulator of the p53 tumor suppressor, is frequently overexpressed in lymphomas, including lymphomas that have inactivated p53. However, the biological consequences of Mdm2 overexpression in lymphocytes are not fully resolved. Here, we report that increased expression of Mdm2 in B cells augmented proliferation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210788
更新日期:2008-03-06 00:00:00
abstract::During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.356
更新日期:2018-02-22 00:00:00
abstract::Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1205996
更新日期:2002-12-16 00:00:00
abstract::Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid interest in cancer research owing to their profound antitumoral activity. The lead compound of the imidazoquinoline family, imiquimod, is marketed as a topical formulation. It is efficacious against many primary skin tumors and cutane...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210913
更新日期:2008-01-07 00:00:00