Abstract:
:Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E6 oncoprotein induces tumorigenic transformation of murine C127 cells and stimulates transcription when targeted to a promoter. BPV-1 E6 was introduced into C127 cells (PBE6) by retroviral infection and stable clones were isolated. These cells showed increased apoptosis in response to TNF, as measured by several criteria. TNF-induced apoptosis in PBE6 cells was accompanied by increased release of arachidonic acid, indicating that phospholipase A2 was activated. We also provide evidence that BPV-1 E6 mediated-sensitization of cells to TNF-induced apoptosis can occur in the absence of p53.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rapp L,Liu Y,Hong Y,Androphy EJ,Chen JJdoi
10.1038/sj.onc.1202373subject
Has Abstractpub_date
1999-01-21 00:00:00pages
607-15issue
3eissn
0950-9232issn
1476-5594journal_volume
18pub_type
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