当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

Abstract：

:The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs. A deregulated form of the p100 gene, which is structurally altered by a t(10;14) translocation, has a potential oncogenic role in certain human B cell lymphomas. In this study p100 was analysed for its ability to interact with its own processing product p52, with p50, the product of the NF-kappa B precursor p105, and with other NF-kappa B/rel-proteins. As demonstrated by a combination of Western blot analysis, band shift analysis and indirect immunofluorescence labelling of transfected cells, p100 itself was localized in the cytoplasm and indiscriminately retained each co-expressed NF-kappa B subunit. Thereby it simultaneously inhibited their DNA binding activities. Thus, a major function of p100 is, like p105, to associate with subunits of the rel multigene family in the cytoplasm in an I kappa B-like fashion. The similarity between p100 and p105 is also reflected by equivalent protein interactions of their processing products: like NF-kappa B-p50, also NF-kappa B-p52 heteromerised promiscuously with all rel-factors tested. Moreover, p52 efficiently interacts with the candidate oncogene product Bcl-3 and also binds to the basic-leucine zipper protein NF-IL6.

journal_name

Oncogene

journal_title

Oncogene

authors

Naumann M,Nieters A,Hatada EN,Scheidereit C

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

2275-81

issue

8

eissn

0950-9232

issn

1476-5594

journal_volume

8

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress.

    abstract：:Ferritin is the major intracellular iron storage protein that sequesters excess free iron to minimize generation of iron-catalysed reactive oxygen species. We previously demonstrated that expression of ferritin heavy chain (ferritin H) was induced by pro-oxidants, which is a part of cellular antioxidant response to pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208901

    authors： Tsuji Y

    更新日期：2005-11-17 00:00:00

  • Evidence for human DNA-mediated transfer of the suppressed phenotype into malignant Chinese hamster cells.

    abstract：:Genetic suppression of the neoplastic phenotype has been demonstrated in somatic cell hybrids between tumor and normal cells. Suppression in whole-cell and microcell hybrids cannot, as yet, be attributed to specific elements defined at the molecular level. To identify a gene capable of suppressing the neoplastic pheno...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Schäfer R,Nirkko AC,Ambühl PM,Grzeschik KH,Schwarte-Waldhoff I

    更新日期：1991-12-01 00:00:00

  • Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.

    abstract：:Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a solu...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.55

    authors： Edmond V,Dufour F,Poiroux G,Shoji K,Malleter M,Fouqué A,Tauzin S,Rimokh R,Sergent O,Penna A,Dupuy A,Levade T,Theret N,Micheau O,Ségui B,Legembre P

    更新日期：2015-02-19 00:00:00

  • Altered expression of Erg and Ets-2 transcription factors is associated with genetic changes at 21q22.2-22.3 in immortal and cervical carcinoma cell lines.

    abstract：:Human Papillomavirus (HPV) type 16 is the most frequently detected HPV in cervical cancer. Although epidemiologic and experimental evidence indicates a prominent role for HPV infection in the development of this disease, other factors are also involved. Altered expression of the ets family transcription factors erg an...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201058

    authors： Simpson S,Woodworth CD,DiPaolo JA

    更新日期：1997-05-08 00:00:00

  • ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.

    abstract：:High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and its expression is even higher in tumor omentum than in normal omentum, the preferred site of ovarian cancer metastasis. The proteo...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-1194-7

    authors： Chen C,Gupta P,Parashar D,Nair GG,George J,Geethadevi A,Wang W,Tsaih SW,Bradley W,Ramchandran R,Rader JS,Chaluvally-Raghavan P,Pradeep S

    更新日期：2020-04-01 00:00:00

  • Vital functions for lethal caspases.

    abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1208524

    authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

    更新日期：2005-08-04 00:00:00

  • DNA methylation and gene silencing in cancer: which is the guilty party?

    abstract：:The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a reversal of methylation states. CpG island associated genes, in particular tumour suppressor or rel...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1205598

    authors： Clark SJ,Melki J

    更新日期：2002-08-12 00:00:00

  • The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.

    abstract：:Sam68 phosphorylation correlates with Fyn but not Lck expression in T cells. This substrate has been used here to explore the possible basis of the specificity of Fyn versus Lck. We show that this specificity is not based on a spatial segregation of the two kinases, since a chimeric Lck molecule containing the membran...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205929

    authors： Feuillet V,Semichon M,Restouin A,Harriague J,Janzen J,Magee A,Collette Y,Bismuth G

    更新日期：2002-10-17 00:00:00

  • miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.

    abstract：:The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.381

    authors： Du L,Zhao Z,Ma X,Hsiao TH,Chen Y,Young E,Suraokar M,Wistuba I,Minna JD,Pertsemlidis A

    更新日期：2014-08-21 00:00:00

  • Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing.

    abstract：:Homology PCR has been used to identify receptor tyrosine kinases (RTKs) expressed during activation of rat hepatic stellate cells, the key fibrogenic mesenchymal element in the liver. Partial cDNAs encoding several RTKs were cloned from stellate cells activated in vivo, including those of Flt-1, Flk-1, c-met, PDGFR, a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201912

    authors： Ankoma-Sey V,Matli M,Chang KB,Lalazar A,Donner DB,Wong L,Warren RS,Friedman SL

    更新日期：1998-07-09 00:00:00

  • G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.

    abstract：:Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomestatin, which is known to stabilize G-quadruplex structures at 3' single-stranded telomeric overhangs (G-tails)...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209217

    authors： Tahara H,Shin-Ya K,Seimiya H,Yamada H,Tsuruo T,Ide T

    更新日期：2006-03-23 00:00:00

  • Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays.

    abstract：:Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast tumorigenesis and developing new diagnostic and therapeutic agents. In this study we have combined two powerful technologies, PCR-based cDNA subtraction and cDNA microa...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205278

    authors： Jiang Y,Harlocker SL,Molesh DA,Dillon DC,Stolk JA,Houghton RL,Repasky EA,Badaro R,Reed SG,Xu J

    更新日期：2002-03-28 00:00:00

  • Pim kinase-dependent inhibition of c-Myc degradation.

    abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.123

    authors： Zhang Y,Wang Z,Li X,Magnuson NS

    更新日期：2008-08-14 00:00:00

  • Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists.

    abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1204187

    authors： Kranenburg O,Moolenaar WH

    更新日期：2001-03-26 00:00:00

  • Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells.

    abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202599

    authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

    更新日期：1999-04-22 00:00:00

  • Activation of the colony-stimulating factor 1 receptor leads to the rapid tyrosine phosphorylation of GTPase-activating protein and activation of cellular p21ras.

    abstract：:We have previously reported that platelet-derived growth factor (PDGF) induced tyrosine phosphorylation of GTPase-activating protein (GAP) in intact quiescent fibroblasts under conditions in which insulin and basic fibroblast growth factor (bFGF) were ineffective (Molloy et al., 1988). In the present study, we have pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Heidaran MA,Molloy CJ,Pangelinan M,Choudhury GG,Wang LM,Fleming TP,Sakaguchi AY,Pierce JH

    更新日期：1992-01-01 00:00:00

  • Mutant p53: an oncogenic transcription factor.

    abstract：:Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1210296

    authors： Strano S,Dell'Orso S,Di Agostino S,Fontemaggi G,Sacchi A,Blandino G

    更新日期：2007-04-02 00:00:00

  • Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.

    abstract：:To investigate the tumorigenic potential of mutant p53 when selectively expressed in lung tissue, a transgenic mouse model was developed in which a mutant form of p53 (p53-273H) was placed under the transcriptional control of the lung-specific human surfactant protein C (SP-C) promoter. Two founder mice were identifie...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205909

    authors： Duan W,Ding H,Subler MA,Zhu WG,Zhang H,Stoner GD,Windle JJ,Otterson GA,Villalona-Calero MA

    更新日期：2002-11-07 00:00:00

  • Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: growth inhibition and differentiation of B16-F10.9 tumor cells.

    abstract：:Interleukin-6 (IL-6) inhibits the growth of melanocytes and of early stage melanoma cells, but not that of advanced melanoma cells. The in vitro IL-6 response can be restored in the highly metastatic melanoma B16-F10.9 by addition of recombinant soluble IL-6 receptor alpha-chain (sIL-6R). The F10.9 cells then undergo ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201213

    authors： Oh JW,Katz A,Harroch S,Eisenbach L,Revel M,Chebath J

    更新日期：1997-07-31 00:00:00

  • STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation.

    abstract：:Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, promotes the development of colorectal cancer, and is a key molecular target of non-steroidal anti-inflammatory drugs, compounds that reduce the relative risk of developing colon cancer. In this study, we showed that interferon gamm...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210015

    authors： Klampfer L,Huang J,Kaler P,Sasazuki T,Shirasawa S,Augenlicht L

    更新日期：2007-03-29 00:00:00

  • The regulation of translation by the 5' untranslated region of Xenopus c-myc I mRNA during early development.

    abstract：:The translational efficiency of chloramphenicol acetyltransferase (CAT) mRNA containing 5' untranslated region (UTR) sequences of Xenopus c-myc I mRNA was examined in the Xenopus oocyte and early embryo. In contrast to their reduced translation in the oocyte, CAT mRNAs containing 5' UTR sequences located between the c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Lazarus P

    更新日期：1992-05-01 00:00:00

  • ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.

    abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.356

    authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

    更新日期：2018-02-22 00:00:00

  • Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.

    abstract：:The majority (75%) of human breast cancers express estrogen receptor (ER). Although ER-positive tumors usually respond to antiestrogen therapies, 30% of them do not. It is not known what controls the ER status of breast cancers or their responsiveness to antihormone interventions. In this report, we document that tran...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208597

    authors： Zhang X,Podsypanina K,Huang S,Mohsin SK,Chamness GC,Hatsell S,Cowin P,Schiff R,Li Y

    更新日期：2005-06-16 00:00:00

  • UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression.

    abstract：:An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known to occur during the epithelial-mesenchymal transition (EMT), a process that promotes metastasi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0885-4

    authors： Arnold JM,Gu F,Ambati CR,Rasaily U,Ramirez-Pena E,Joseph R,Manikkam M,San Martin R,Charles C,Pan Y,Chatterjee SS,Den Hollander P,Zhang W,Nagi C,Sikora AG,Rowley D,Putluri N,Zhang XH,Karanam B,Mani SA,Sreekumar A

    更新日期：2020-04-01 00:00:00

  • Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.

    abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

    journal_title：Oncogene

    pub_type： 已发布勘误

    doi：10.1038/s41388-020-1283-7

    authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

    更新日期：2020-10-01 00:00:00

  • CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.

    abstract：:CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.301

    authors： Ward Y,Lake R,Martin PL,Killian K,Salerno P,Wang T,Meltzer P,Merino M,Cheng SY,Santoro M,Garcia-Rostan G,Kelly K

    更新日期：2013-05-30 00:00:00

  • Cell context reveals a dual role for Maf in oncogenesis.

    abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209171

    authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

    更新日期：2006-03-02 00:00:00

  • PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.

    abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210290

    authors： Liu X,Hu Y,Hao C,Rempel SA,Ye K

    更新日期：2007-07-26 00:00:00

  • Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines.

    abstract：:We have compared the DNase I hypersensitivity of the regulatory region of two estrogen-regulated genes, pS2 and cathepsin D in hormone-dependent and -independent breast carcinoma cell lines. This strategy allowed the identification of two important control regions, one in pS2 and the other in cathepsin D genes. In the...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202317

    authors： Giamarchi C,Solanas M,Chailleux C,Augereau P,Vignon F,Rochefort H,Richard-Foy H

    更新日期：1999-01-14 00:00:00

  • MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism.

    abstract：:The Mucin 1 (MUC1) protein is overexpressed in various cancers and mediates chemotherapy resistance. However, the mechanism is not fully understood. Given that most chemotherapeutic drugs disrupt ER homeostasis as part of their toxicity, and MUC1 expression is regulated by proteins involved in ER homeostasis, we inves...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-1225-4

    authors： Olou AA,King RJ,Yu F,Singh PK

    更新日期：2020-04-01 00:00:00