Abstract:
:Genetic suppression of the neoplastic phenotype has been demonstrated in somatic cell hybrids between tumor and normal cells. Suppression in whole-cell and microcell hybrids cannot, as yet, be attributed to specific elements defined at the molecular level. To identify a gene capable of suppressing the neoplastic phenotype, we have introduced DNA of normal human cells into tumorigenic Chinese hamster Wg3-h-o cells. Primary and secondary transfectants which exhibit the suppressed phenotype similar to Wg3-h-o x embryonic fibroblast hybrids were selected. The cells require serum growth factors and anchorage for proliferation in vitro and show a reduced tumorigenicity in nude mice. Transferred human DNA segments were molecularly cloned from a secondary transfectant. Indirect evidence suggests that the cloned human DNA is associated with the expression of the suppressed phenotype.
journal_name
Oncogenejournal_title
Oncogeneauthors
Schäfer R,Nirkko AC,Ambühl PM,Grzeschik KH,Schwarte-Waldhoff Isubject
Has Abstractpub_date
1991-12-01 00:00:00pages
2221-8issue
12eissn
0950-9232issn
1476-5594journal_volume
6pub_type
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