In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00

abstract：:The translational efficiency of chloramphenicol acetyltransferase (CAT) mRNA containing 5' untranslated region (UTR) sequences of Xenopus c-myc I mRNA was examined in the Xenopus oocyte and early embryo. In contrast to their reduced translation in the oocyte, CAT mRNAs containing 5' UTR sequences located between the c...

journal_title：Oncogene

authors： Lazarus P

更新日期：1992-05-01 00:00:00

abstract：:The function of the class III histone deacetylase, Sir2, in promoting lifespan extension is well established in small model organisms. By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-associated diseases. We have used SirT1-null mice to study th...

journal_title：Oncogene

authors： Boily G,He XH,Pearce B,Jardine K,McBurney MW

更新日期：2009-08-13 00:00:00

abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...

journal_title：Oncogene

authors： Siyanova EY,Serfas MS,Mazo IA,Tyner AL

更新日期：1994-07-01 00:00:00

abstract：:There is an emerging body of evidence implicating iron in carcinogenesis and in particular colorectal cancer, but whether this involves Wnt signalling, a major oncogenic signalling pathway has not been studied. We aimed to determine the effect of iron loading on Wnt signalling using mutant APC (Caco-2 and SW480) and w...

journal_title：Oncogene

authors： Brookes MJ,Boult J,Roberts K,Cooper BT,Hotchin NA,Matthews G,Iqbal T,Tselepis C

更新日期：2008-02-07 00:00:00

abstract：:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a crit...

journal_title：Oncogene

authors： Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui X

更新日期：2012-11-08 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...

journal_title：Oncogene

authors： Kleeff J,Ishiwata T,Maruyama H,Friess H,Truong P,Büchler MW,Falb D,Korc M

更新日期：1999-09-23 00:00:00

abstract：:Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...

journal_title：Oncogene

authors： Krokan HE,Drabløs F,Slupphaug G

更新日期：2002-12-16 00:00:00

abstract：:Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...

journal_title：Oncogene

authors： Rodríguez MI,González-Flores A,Dantzer F,Collard J,de Herreros AG,Oliver FJ

更新日期：2011-10-20 00:00:00

abstract：:Members of the Wnt family induce mouse mammary tumors and partially transform mammary epithelial cells in culture. However, their mechanism of transformation remains to be elucidated. In NIH3T3 mouse embryo fibroblasts, a standard transformation model, Wnt-1 and Wnt-2 were shown to induce altered properties including ...

journal_title：Oncogene

authors： Bafico A,Gazit A,Wu-Morgan SS,Yaniv A,Aaronson SA

更新日期：1998-05-28 00:00:00

abstract：:Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Kasugai Y,Tuzuki S,Suzuki R,Hosokawa Y,Seto M

更新日期：2004-04-01 00:00:00

abstract：:It is well known that intracellular antioxidant glutathione (GSH) plays major roles in the maintenance of redox status and defense of oxidative stress. Ras, a small GTP-binding protein, may send growth-stimulating message to the nucleus through downstream Rac oncoprotein and superoxide (O(2*-)). These findings led us ...

journal_title：Oncogene

authors： Chuang JI,Chang TY,Liu HS

更新日期：2003-03-06 00:00:00

abstract：:Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. However, the effects of Kit activation on the c...

journal_title：Oncogene

authors： Plo I,Lautier D,Casteran N,Dubreuil P,Arock M,Laurent G

更新日期：2001-10-11 00:00:00

abstract：:SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin structure in a wide variety of developmental processes. Sox5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of platelet-derived gr...

journal_title：Oncogene

authors： Tchougounova E,Jiang Y,Bråsäter D,Lindberg N,Kastemar M,Asplund A,Westermark B,Uhrbom L

更新日期：2009-03-26 00:00:00

abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...

journal_title：Oncogene

authors： Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

更新日期：2013-08-08 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Since defects in molecular mechanisms controlling DNA repair, cell cycle checkpoint and apoptosis could modify cellular sensitivity to DNA damaging agents, we have conducted a multiparametric molecular analysis for better understanding the regulation pathways leading to cell survival or cell death after irradiation. U...

journal_title：Oncogene

authors： Bishay K,Ory K,Lebeau J,Levalois C,Olivier MF,Chevillard S

更新日期：2000-02-17 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:The Epstein-Barr virus latency-associated membrane protein LMP2A has been shown to activate the survival kinase Akt in epithelial and B cells in a phosphoinositide 3-kinase-dependent fashion. In this study, we demonstrate that the signalling scaffold Shb associates through SH2 and PTB domain interactions with phosphor...

journal_title：Oncogene

authors： Matskova LV,Helmstetter C,Ingham RJ,Gish G,Lindholm CK,Ernberg I,Pawson T,Winberg G

更新日期：2007-07-26 00:00:00

abstract：:Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...

journal_title：Oncogene

authors： Pandita TK,Hall EJ,Hei TK,Piatyszek MA,Wright WE,Piao CQ,Pandita RK,Willey JC,Geard CR,Kastan MB,Shay JW

更新日期：1996-10-03 00:00:00

abstract：:T-cell antigen receptor stimulation results in phosphorylation of the SH2 containing Shc proteins and recruitment of the Grb2/mSos complex suggesting that Shc proteins are involved in transducing T-cell activating signals to Ras. We have measured the effects of the isolated Shc-SH2 domain and the dominant negative Ras...

journal_title：Oncogene

authors： Baldari CT,Pelicci G,Di Somma MM,Milia E,Giuli S,Pelicci PG,Telford JL

更新日期：1995-03-16 00:00:00

abstract：:Ras genes are activated by point mutations at critical sites of their coding regions. Activated N-ras genes with transforming ability have been detected in patients with myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML) and in human myeloid cell lines. We used polymerase chain reaction (PCR), different...

journal_title：Oncogene

authors： Lübbert M,Jonas D,Miller CW,Herrmann F,Mertelsmann R,McCormick F,Koeffler HP

更新日期：1990-04-01 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...

journal_title：Oncogene

authors： Zhang M,Altuwaijri S,Yeh S

更新日期：2004-04-15 00:00:00

abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

journal_title：Oncogene

authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

更新日期：2017-07-06 00:00:00

abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

journal_title：Oncogene

authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

更新日期：2014-03-20 00:00:00

abstract：:Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...

journal_title：Oncogene

authors： Strano S,Dell'Orso S,Di Agostino S,Fontemaggi G,Sacchi A,Blandino G

更新日期：2007-04-02 00:00:00

abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

journal_title：Oncogene

authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

更新日期：2000-09-07 00:00:00

abstract：:The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...

journal_title：Oncogene

authors： Mo YY,Yu Y,Theodosiou E,Ee PL,Beck WT

更新日期：2005-04-14 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00