Abstract:
:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a critical functional biomarker for BLBC. However, how it orchestrates BLBC cells was not clear. Here we show that FOXC1 activates the transcription factor nuclear factor-κB (NF-κB) in BLBC cells by increasing p65/RelA protein stability. High NF-κB activity has been associated with estrogen receptor-negative breast cancer, particularly BLBC. The effect of FOXC1 on p65/RelA protein stability is mediated by increased expression of Pin1, a peptidyl-prolyl isomerase. FOXC1 requires NF-κB for its regulation of cell proliferation, migration and invasion. Notably, FOXC1 overexpression renders breast cancer cells more susceptible to pharmacological inhibition of NF-κB. These results suggest that BLBC cells may rely on FOXC1-driven NF-κB signaling. Interventions of this pathway may provide modalities for the treatment of BLBC.
journal_name
Oncogenejournal_title
Oncogeneauthors
Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui Xdoi
10.1038/onc.2011.635subject
Has Abstractpub_date
2012-11-08 00:00:00pages
4798-802issue
45eissn
0950-9232issn
1476-5594pii
onc2011635journal_volume
31pub_type
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