Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists.


:Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathways, thereby exerting non-apoptotic functions beyond the inhibition of apoptosis. For example, IAP proteins have been implied in the control of cell motility, migration, invasion and metastasis. However, currently the question is controversially discussed whether or not they positively or negatively control these processes. As small-molecule inhibitors of IAP proteins have entered the stage of clinical evaluation as experimental cancer therapeutics, a better understanding of their various cellular effects will be critical for their rational use in the treatment of human diseases.






Fulda S




Has Abstract


2014-02-06 00:00:00
















  • Control of MAPK signalling: from complexity to what really matters.

    abstract::Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...


    pub_type: 杂志文章


    authors: Hornberg JJ,Binder B,Bruggeman FJ,Schoeberl B,Heinrich R,Westerhoff HV

    更新日期:2005-08-25 00:00:00

  • CCND1 polymorphism and age of onset of hepatoblastoma.

    abstract::Cyclin D1, encoded by the gene CCND1, is a major regulator of the cell cycle transition from G1 phase to S phase. A CCND1 polymorphism (G to A) at codon 242, the boundary of exon 4 and intron 4, affects splicing such that exon 5 is not expressed in the A allele. Since exon 5 is involved in rapid turnover, the variant ...


    pub_type: 杂志文章


    authors: Pakakasama S,Chen TT,Frawley W,Muller CY,Douglass EC,Lee R,Pollock BH,Tomlinson GE

    更新日期:2004-06-10 00:00:00

  • Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.

    abstract::After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...


    pub_type: 已发布勘误


    authors: Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

    更新日期:2020-10-01 00:00:00

  • Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells.

    abstract::As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...


    pub_type: 杂志文章


    authors: Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

    更新日期:2010-06-03 00:00:00

  • Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion.

    abstract::Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...


    pub_type: 杂志文章


    authors: Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

    更新日期:2010-10-07 00:00:00

  • Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.

    abstract::Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...


    pub_type: 杂志文章


    authors: Schulte JH,Schramm A,Klein-Hitpass L,Klenk M,Wessels H,Hauffa BP,Eils J,Eils R,Brodeur GM,Schweigerer L,Havers W,Eggert A

    更新日期:2005-01-06 00:00:00

  • Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.

    abstract::Most colorectal carcinomas harbor genetic alterations that result in stabilization of beta-catenin. A colorectal carcinoma cell line, HCT116, which has both mutated and wild-type beta-catenin genes, was engineered by homologous recombination to investigate the significance of beta-catenin gene mutation. As expected, t...


    pub_type: 杂志文章


    authors: Sekine S,Shibata T,Sakamoto M,Hirohashi S

    更新日期:2002-08-29 00:00:00

  • Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts.

    abstract::Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...


    pub_type: 杂志文章


    authors: Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

    更新日期:2010-06-03 00:00:00

  • Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels.

    abstract::Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory co...


    pub_type: 杂志文章,评审


    authors: Fonsatti E,Altomonte M,Nicotra MR,Natali PG,Maio M

    更新日期:2003-09-29 00:00:00

  • TGFβ signaling in head and neck squamous cell carcinoma.

    abstract::Transforming growth factor beta (TGFβ) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFβ signaling maintains epithelial homeostasis, dysregulated TGFβ signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGFβ sign...


    pub_type: 杂志文章,评审


    authors: White RA,Malkoski SP,Wang XJ

    更新日期:2010-10-07 00:00:00

  • Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12.

    abstract::A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...




    authors: Jacob AN,Kandpal G,Kandpal RP

    更新日期:1996-07-04 00:00:00

  • TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.

    abstract::Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...


    pub_type: 杂志文章


    authors: Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

    更新日期:2013-08-08 00:00:00

  • Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms.

    abstract::E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...


    pub_type: 杂志文章


    authors: Teodoro JG,Shore GC,Branton PE

    更新日期:1995-08-03 00:00:00

  • Progesterone enhances branching morphogenesis in the mouse mammary gland by increased expression of Msx2.

    abstract::Branching morphogenesis within the peripubertal mouse mammary gland is directed by progesterone (P). A role for the homeobox-containing transcription factor, Msx2, during branching morphogenesis is suggested from its ontogenic expression profile and hormonal regulation. Herein, we define the spatio-temporal control of...


    pub_type: 杂志文章


    authors: Satoh K,Hovey RC,Malewski T,Warri A,Goldhar AS,Ginsburg E,Saito K,Lydon JP,Vonderhaar BK

    更新日期:2007-11-29 00:00:00

  • Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.

    abstract::Juvenile myelomonocytic leukemia (JMML) is a malignant hematopoietic disorder whose proliferative component is a result of RAS pathway deregulation caused by somatic mutation in the RAS or PTPN11 oncogenes or in patients with underlying neurofibromatosis type 1 (NF-1), by loss of NF1 gene function. To search for poten...


    pub_type: 杂志文章


    authors: Flotho C,Steinemann D,Mullighan CG,Neale G,Mayer K,Kratz CP,Schlegelberger B,Downing JR,Niemeyer CM

    更新日期:2007-08-23 00:00:00

  • Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach.

    abstract::Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...


    pub_type: 杂志文章


    authors: Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

    更新日期:2011-02-10 00:00:00

  • Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage.

    abstract::The p53 tumor suppressor protein plays a critical role in mediating cellular response to stress. Upon DNA damage, post-translational modifications stabilize and activate this nuclear phosphoprotein. To determine the effect of phosphorylation site mutants in the context of the whole p53 protein, we performed reporter a...


    pub_type: 杂志文章


    authors: Dohoney KM,Guillerm C,Whiteford C,Elbi C,Lambert PF,Hager GL,Brady JN

    更新日期:2004-01-08 00:00:00

  • HGF-independent potentiation of EGFR action by c-Met.

    abstract::The c-Met receptor is a potential therapeutic target for non-small cell lung cancer (NSCLC). Signaling interactions between c-Met and the mutant epidermal growth factor receptor (EGFR) have been studied extensively, but signaling intermediates and biological consequences of lateral signaling to c-Met in EGFR wild-type...


    pub_type: 杂志文章


    authors: Dulak AM,Gubish CT,Stabile LP,Henry C,Siegfried JM

    更新日期:2011-08-18 00:00:00

  • Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection.

    abstract::TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...


    pub_type: 杂志文章


    authors: Clarke P,Meintzer SM,Spalding AC,Johnson GL,Tyler KL

    更新日期:2001-10-18 00:00:00

  • Epigenetic regulations in hematopoietic Hox code.

    abstract::Hox genes encode DNA-binding proteins that are deployed in overlapping domains along various body axes during embryonic development. This sequential activation of Hox genes in temporal and spatial mode, the Hox code, is critical for the proper positioning of segmented structures along those axes, which include the ver...


    pub_type: 杂志文章,评审


    authors: He H,Hua X,Yan J

    更新日期:2011-01-27 00:00:00

  • Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5.

    abstract::Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...


    pub_type: 杂志文章


    authors: Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

    更新日期:2006-02-09 00:00:00

  • Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer.

    abstract::We analysed breast tumors and breast cancer cell lines for the expression of beta-parvin (ParvB), an adaptor protein that binds to the integrin-linked kinase (ILK). Quantitative RT-PCR indicated that ParvB mRNA was downregulated, by at least 60%, in four of nine breast tumors, relative to patient-matched normal mammar...


    pub_type: 杂志文章


    authors: Mongroo PS,Johnstone CN,Naruszewicz I,Leung-Hagesteijn C,Sung RK,Carnio L,Rustgi AK,Hannigan GE

    更新日期:2004-11-25 00:00:00

  • KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties.

    abstract::Studies have reported that interactions between keratins (KRTs) and other proteins initiate signaling cascades that regulate cell migration, invasion, and metastasis. In the current study, we found that expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Mo...


    pub_type: 杂志文章


    authors: Saha SK,Choi HY,Kim BW,Dayem AA,Yang GM,Kim KS,Yin YF,Cho SG

    更新日期:2017-01-19 00:00:00

  • Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis.

    abstract::Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...


    pub_type: 杂志文章


    authors: Leung N,Turbide C,Olson M,Marcus V,Jothy S,Beauchemin N

    更新日期:2006-09-07 00:00:00

  • Future prospects for oncolytic therapy.

    abstract::Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...


    pub_type: 杂志文章


    authors: McCormick F

    更新日期:2005-11-21 00:00:00

  • WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

    abstract::ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...


    pub_type: 杂志文章


    authors: Li Y,Zhou Z,Alimandi M,Chen C

    更新日期:2009-08-20 00:00:00

  • BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.

    abstract::The BRCA1-associated RING domain protein BARD1 acts with BRCA1 in double-strand break repair and ubiquitination. BARD1 plays a role as mediator of apoptosis by binding to and stabilizing p53, and BARD1-repressed cells are resistant to apoptosis. We therefore investigated the mechanism by which BARD1 induces p53 stabil...


    pub_type: 杂志文章


    authors: Feki A,Jefford CE,Berardi P,Wu JY,Cartier L,Krause KH,Irminger-Finger I

    更新日期:2005-05-26 00:00:00

  • Indistinct cell cycle checkpoint after u.v. damage in H-ras-transformed mouse liver cells despite normal p53 gene expression.

    abstract::Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...


    pub_type: 杂志文章


    authors: Kadohama T,Tsuji K,Ogawa K

    更新日期:1994-10-01 00:00:00

  • Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

    abstract::Mcl-1 is an antiapoptotic member of the Bcl-2 family that can promote cell viability. We report here that Mcl-1 is a new substrate for caspases during induction of apoptosis. Mcl-1 cleavage occurs after Asp127 and Asp157 and generates four fragments of 24, 19, 17 and 12 kDa in both intact cells and in vitro, an effect...


    pub_type: 杂志文章


    authors: Herrant M,Jacquel A,Marchetti S,Belhacène N,Colosetti P,Luciano F,Auberger P

    更新日期:2004-10-14 00:00:00

  • Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol.

    abstract::Radicicol, a macrocyclic anti-fungal antibiotic, has the ability to suppress transformation by diverse oncogenes such as Src, Ras and Mos. Despite this useful property, the mechanism by which radicicol exerts its anti-transformation effects is currently unknown. To understand the transformation-suppressing effects of ...


    pub_type: 杂志文章


    authors: Sharma SV,Agatsuma T,Nakano H

    更新日期:1998-05-01 00:00:00