当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma.

Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma.

Abstract：

:The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM, we have assessed their expression and biological activity. Comparing Affymetrix DNA-microarray-expression-profiles of CD138-purified plasma-cells from 65 MM-patients and 7 normal individuals to those of plasmablasts and B-cells, we found 5/10 EGF-family genes to be expressed in MMC. Neuregulin-2 and neuregulin-3 were expressed by MMC only, while neuregulin-1, amphiregulin and transforming growth factor-alpha were expressed by both MMC and normal plasma-cells. Using real-time polymerase chain reaction, we found HB-EGF, amphiregulin, neuregulin-1 and epiregulin to be expressed by cells from the bone marrow-environment. Only the EGF-members able to bind heparan-sulphate proteoglycans (HSPGs) - neuregulin-1, amphiregulin, HB-EGF - promote the growth of MMC. Those ligands strongly bind MMC through HSPGs. The binding and the MMC growth activity was abrogated by heparitinase, heparin or deletion of the HS-binding domain. The number of HS-binding EGF ligand molecules bound to MMC was higher than 10(5) molecules/cell and paralleled that of syndecan-1. Syndecan-1, the main HSPG present on MM cells, likely concentrates high levels of HS-binding-EGF-ligands at the cell membrane and facilitates ErbB-activation. Altogether, our data further identify EGF-signalling as promising target for MM-therapy.

journal_name

Oncogene

journal_title

Oncogene

authors

Mahtouk K,Cremer FW,Rème T,Jourdan M,Baudard M,Moreaux J,Requirand G,Fiol G,De Vos J,Moos M,Quittet P,Goldschmidt H,Rossi JF,Hose D,Klein B

doi

10.1038/sj.onc.1209699

subject

Has Abstract

pub_date

2006-11-16 00:00:00

pages

7180-91

issue

54

eissn

0950-9232

issn

1476-5594

pii

1209699

journal_volume

25

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

    abstract：:The mouse int6 gene is a frequent integration site of the mouse mammary tumor virus and INT6 silencing by RNA interference in HeLa cells causes an increased number of cells in the G2/M phases of the cell cycle, along with mitotic defects. In this report, we investigated the functional significance of the interaction b...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210314

    authors： Buchsbaum S,Morris C,Bochard V,Jalinot P

    更新日期：2007-08-02 00:00:00

  • Adenovirus E1a as a tumor-suppressor gene.

    abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：

    authors： Chinnadurai G

    更新日期：1992-07-01 00:00:00

  • Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22.

    abstract：:Frequent allelic losses of chromosome 3p in lung cancer have been reported in a number of studies, and we previously demonstrated that 3p21.3 is one of the common regions of deletion in lung cancers and renal cell carcinomas. To further define a region containing the putative tumor suppressor gene, we performed Southe...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Yamakawa K,Takahashi T,Horio Y,Murata Y,Takahashi E,Hibi K,Yokoyama S,Ueda R,Takahashi T,Nakamura Y

    更新日期：1993-02-01 00:00:00

  • rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral.

    abstract：:A novel oncogene, rsc (rabbit squamous cell carcinoma), has been identified from a DMBA-induced rabbit squamous cell carcinoma using gene transfer and the nude mouse tumorigenesis assay. A full-length cDNA has been isolated and sequenced. rsc has potent tumorigenic activity in nude mice (latency <4 weeks), but does no...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200950

    authors： D'Adamo DR,Novick S,Kahn JM,Leonardi P,Pellicer A

    更新日期：1997-03-20 00:00:00

  • The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.

    abstract：:Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201153

    authors： Ueno H,Honda H,Nakamoto T,Yamagata T,Sasaki K,Miyagawa K,Mitani K,Yazaki Y,Hirai H

    更新日期：1997-06-26 00:00:00

  • CD4 and p56lck can stably associate when co-expressed in NIH3T3 cells.

    abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Simpson SC,Bolen JB,Veillette A

    更新日期：1989-09-01 00:00:00

  • HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation.

    abstract：:It has recently been shown that the high-risk human papillomavirus (HPV) E6 proteins can target the PDZ-domain containing proteins, Dlg, MUPP-1, MAGI-1 and hScrib for proteasome-mediated degradation. However, the E6 proteins from HPV-16 and HPV-18 (the two most common high-risk virus types) differ in their ability to ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204719

    authors： Thomas M,Glaunsinger B,Pim D,Javier R,Banks L

    更新日期：2001-09-06 00:00:00

  • Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer among men in the developed world. There is a need, for both clinical and scientific reasons, to find markers to identify patients with aggressive disease as early as possible, and to understand the events leading to malignant transformation ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207345

    authors： Cromer A,Carles A,Millon R,Ganguli G,Chalmel F,Lemaire F,Young J,Dembélé D,Thibault C,Muller D,Poch O,Abecassis J,Wasylyk B

    更新日期：2004-04-01 00:00:00

  • Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.

    abstract：:Overexpression of hepatocyte growth factor (HGF), also called scatter factor (SF), and its receptor c-Met are associated with poor prognosis for cancer patients. In particular, breast cancer cells can produce HGF that acts in a paracrine as well as in an autocrine manner. Therefore, HGF and c-Met are putative targets ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207063

    authors： Gallego MI,Bierie B,Hennighausen L

    更新日期：2003-11-20 00:00:00

  • Catch of the day: zebrafish as a human cancer model.

    abstract：:Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects o...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2008.95

    authors： Stoletov K,Klemke R

    更新日期：2008-07-31 00:00:00

  • The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library.

    abstract：:Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208839

    authors： Kawaguchi T,Kato S,Otsuka K,Watanabe G,Kumabe T,Tominaga T,Yoshimoto T,Ishioka C

    更新日期：2005-10-20 00:00:00

  • Stabilization of prolactin receptor in breast cancer cells.

    abstract：:The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209214

    authors： Li Y,Clevenger CV,Minkovsky N,Kumar KG,Raghunath PN,Tomaszewski JE,Spiegelman VS,Fuchs SY

    更新日期：2006-03-23 00:00:00

  • Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex.

    abstract：:Collagenase1 (MMP1) and stromelysin1 (MMP3) are extracellular proteolytic enzymes that degrade connective tissue macromolecules and basement membranes. Both genes are regulated by the Ets and Fos/Jun families of transcription factors/oncoproteins. Here, we show that two members of the Ets-family, Ets2 and Erg and thei...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Butticè G,Duterque-Coquillaud M,Basuyaux JP,Carrère S,Kurkinen M,Stéhelin D

    更新日期：1996-12-05 00:00:00

  • Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.

    abstract：:RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. We used RasGRP1 trans...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208334

    authors： Klinger MB,Guilbault B,Goulding RE,Kay RJ

    更新日期：2005-04-14 00:00:00

  • LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.

    abstract：:Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated that, in mouse embr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.290

    authors： Zeng Q,Chen J,Li Y,Werle KD,Zhao RX,Quan CS,Wang YS,Zhai YX,Wang JW,Youssef M,Cui R,Liang J,Genovese N,Chow LT,Li YL,Xu ZX

    更新日期：2017-03-02 00:00:00

  • TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer.

    abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

    journal_title：Oncogene

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/onc.2013.527

    authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

    更新日期：2015-01-02 00:00:00

  • CHF: a novel factor binding to cyclin A CHR corepressor element.

    abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203017

    authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

    更新日期：1999-11-04 00:00:00

  • TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

    abstract：:Radioresistance becomes the major obstacle to reduce tumor recurrence and improve prognosis in the treatment of esophageal squamous cell carcinoma (ESCC). Thus new strategies for radioresistant ESCC are urgently needed. Herein, we reported that tribbles pseudokinase 3 (TRIB3) serves as a key regulator of radioresistan...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-1245-0

    authors： Zhou S,Liu S,Lin C,Li Y,Ye L,Wu X,Jian Y,Dai Y,Ouyang Y,Zhao L,Liu M,Song L,Xi M

    更新日期：2020-04-01 00:00:00

  • The erythropoietin-receptor pathway modulates survival of cancer cells.

    abstract：:Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the use of erythropoietin to correct cancer anemia and to improve radiation efficacy was disappointing. Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactiva...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208140

    authors： Pajonk F,Weil A,Sommer A,Suwinski R,Henke M

    更新日期：2004-11-25 00:00:00

  • Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells.

    abstract：:The co-chaperone protein, BAG3, which belongs to the BAG protein family, has an established antiapoptotic function in different tumor cell lines. Here we demonstrated that treatment of the human neuroblastoma cell line, SK-N-MC, with fibroblast growth factor-2 (FGF-2) results in induction of BAG3 expression. Induction...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.142

    authors： Gentilella A,Passiatore G,Deshmane S,Turco MC,Khalili K

    更新日期：2008-08-28 00:00:00

  • RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells.

    abstract：:Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.104

    authors： Zhu Y,Das K,Wu J,Lee MH,Tan P

    更新日期：2014-03-20 00:00:00

  • Induction of a complex between rasGAP and a novel 110 kD protein is required for immortalization of primary epithelial cells by the E1A 12S oncoprotein of adenovirus.

    abstract：:Although established cell lines can be transformed with oncogenic ras, primary epithelial cells cannot, but require the coexpression of an immortalizing oncogene, such as the E1A region of adenovirus. We have previously shown that immortalization of primary epithelial cells by E1A 12S requires the expression of five r...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Gopalakrishnan S,Fischer RS,Quinlan MP

    更新日期：1996-12-19 00:00:00

  • Identification of a nuclear targeting sequence in the Fos protein.

    abstract：:The product of the proto-oncogene fos is a nuclear phosphoprotein. We have investigated if nuclear location of Fos protein is mediated by a nuclear targeting sequence. We show that the cytoplasmic chicken pyruvate kinase protein translocates to the nucleus if fused to the 22 amino acid Fos basic region (amino acids 13...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Tratner I,Verma IM

    更新日期：1991-11-01 00:00:00

  • Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells.

    abstract：:Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.84

    authors： Origanti S,Cai SR,Munir AZ,White LS,Piwnica-Worms H

    更新日期：2013-01-31 00:00:00

  • Core transcriptional regulatory circuitries in cancer.

    abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/s41388-020-01459-w

    authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

    更新日期：2020-10-01 00:00:00

  • Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment.

    abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Snijders AJ,Haase VH,Bernards A

    更新日期：1993-01-01 00:00:00

  • Future prospects for oncolytic therapy.

    abstract：:Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209064

    authors： McCormick F

    更新日期：2005-11-21 00:00:00

  • Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A.

    abstract：:Breast cancer cells that overexpress HER-2/neu are more resistant to chemotherapeutic agents such as paclitaxel (Taxol) and docetaxel (Taxotere) than those that do not overexpress HER-2/neu. In previous work, we showed that the adenovirus type 5 E1A can repress HER-2/neu expression at the transcriptional level. Here w...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201250

    authors： Ueno NT,Yu D,Hung MC

    更新日期：1997-08-18 00:00:00

  • Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer.

    abstract：:Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by a mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we demonstrate that ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0289-x

    authors： Knickelbein K,Tong J,Chen D,Wang YJ,Misale S,Bardelli A,Yu J,Zhang L

    更新日期：2018-08-01 00:00:00

  • TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas.

    abstract：:To achieve a better understanding of mechanisms that underlie hepatocarcinogenesis and to identify novel target molecules for diagnosis and therapy of hepatocellular carcinoma (HCC), we previously analysed gene-expression profiles of 20 HCC tissues on a cDNA microarray. Among the genes upregulated in the tumor tissues...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209517

    authors： Silva FP,Hamamoto R,Furukawa Y,Nakamura Y

    更新日期：2006-08-17 00:00:00