Abstract:
:The mouse int6 gene is a frequent integration site of the mouse mammary tumor virus and INT6 silencing by RNA interference in HeLa cells causes an increased number of cells in the G2/M phases of the cell cycle, along with mitotic defects. In this report, we investigated the functional significance of the interaction between INT6 and MCM7, which was observed in a two-hybrid screen performed with INT6 as bait. It was found that proteasome inhibition strengthens interaction between both proteins and that INT6 stabilizes MCM7. Removal of MCM7 from chromatin as replication proceeds was accelerated in INT6-silenced cells and reduced amounts of protein were transiently observed, followed by a correction resulting from stimulation of mcm7 gene expression. Synchronized cells depleted for either INT6 or MCM7 display a reduction in thymidine incorporation and a reinforced association of RPA and claspin with chromatin. These data show that INT6 stabilizes chromatin-bound MCM7 and that alteration of this effect is associated with replication deficiency.
journal_name
Oncogenejournal_title
Oncogeneauthors
Buchsbaum S,Morris C,Bochard V,Jalinot Pdoi
10.1038/sj.onc.1210314subject
Has Abstractpub_date
2007-08-02 00:00:00pages
5132-44issue
35eissn
0950-9232issn
1476-5594pii
1210314journal_volume
26pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201660
更新日期:1998-03-01 00:00:00
abstract::SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-02-16 00:00:00
abstract::The products of two cellular proto-oncogenes c-fos and c-jun form a heterodimeric complex that contribute to the DNA-binding activity referred to as AP-1 (activator protein-1). Two domains have been proposed to be required for heterodimer formation and protein-DNA complex formation. The leucine zipper domain mediated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.463
更新日期:2012-06-07 00:00:00
abstract::In many differentiating cells, a reduction of c-myc proto-oncogene expression is a prerequisite for terminal differentiation. The downmodulation of c-myc in differentiating cells is due to at least two different mechanisms: (i) an elongation block to c-myc transcription activated during an early phase of differentiati...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.82
更新日期:2016-01-14 00:00:00
abstract::Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204187
更新日期:2001-03-26 00:00:00
abstract::Cancer cells recruit monocytes, macrophages and other inflammatory cells by producing abundant chemoattractants and growth factors, such as macrophage colony-stimulating factor (M-CSF/CSF-1) and monocyte chemoattractant protein-1 (MCP-1/CCL2), to promote tumor growth and dissemination. An understanding of the mechanis...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.112
更新日期:2011-09-08 00:00:00
abstract::It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201372
更新日期:1997-10-23 00:00:00
abstract::p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208852
更新日期:2005-11-03 00:00:00
abstract::Stimulation of the endometrium by estrogens without the differentiating effect of progestins is the primary etiological factor associated with the development of endometrial hyperplasia and adenocarcinoma. However, the correlation between sex steroids and gap junctional intercellular communication (GJIC), which is con...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207215
更新日期:2004-02-05 00:00:00
abstract::Formation of meningiomas has been associated with the loss of genetic material on chromosome 22. To approach the additional chromosomal events that underlie progression of these tumors to malignancy, we have examined several other chromosomal regions for loss of heterozygosity (LOH) in these tumors. Fifty-eight tumors...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200853
更新日期:1997-02-06 00:00:00
abstract::Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207892
更新日期:2004-11-04 00:00:00
abstract::The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.441
更新日期:2009-02-12 00:00:00
abstract::The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these reports have not documented the imprinting status of IGF2 at the cellular level, it cannot be excluded that t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201501
更新日期:1998-01-08 00:00:00
abstract::Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.104
更新日期:2016-11-17 00:00:00
abstract::Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.300
更新日期:2010-10-21 00:00:00
abstract::Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205382
更新日期:2002-04-25 00:00:00
abstract::Hedgehog pathway activity has been demonstrated in malignant glioma. However, its role in tumor growth has not been determined. Here we demonstrate that pharmacological inhibition of the Hedgehog pathway in established orthotopic malignant glioma xenografts confers a survival advantage. Pathway inhibition is measured ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.208
更新日期:2009-10-01 00:00:00
abstract::A potential role for 1-oleoyl-sn-glycero-3-phosphate or lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) in the regulation of malignant diseases has been widely considered. In this study, we found that in transformed astroglial cells, the expression profile of lysophospholipid receptor mRNA and the action...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208805
更新日期:2005-10-06 00:00:00
abstract::The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208427
更新日期:2005-05-19 00:00:00
abstract::EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207579
更新日期:2004-05-27 00:00:00
abstract::In the course of screening for inhibitors of tumorigenic phenotype of K-ras-transformed NIH3T3 cells (DT cells), we found a novel compound, oxamflatin, an aromatic sulfonamide hydroxamate derivative, which induces flat phenotype in these cells and suppresses their anchorage-independent growth. In contrast to DT cells,...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-07-04 00:00:00
abstract::Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms. The role of nuclear FGF-2 on the metastatic potential of carcinoma cells was examined by conditional FGF-2 expression, which demonstrated that spontaneous metastasis in nud...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207638
更新日期:2004-06-10 00:00:00
abstract::BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204712
更新日期:2001-09-27 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0985-1
更新日期:2020-01-01 00:00:00
abstract::Checkpoint kinase 2 (Chk2) is known to mediate diverse cellular responses to genotoxic stress. The fundamental role of Chk2 is to regulate the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209059
更新日期:2006-01-19 00:00:00
abstract::The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204910
更新日期:2001-10-25 00:00:00
abstract::Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202290
更新日期:1999-01-14 00:00:00
abstract::Ras-GRF, a guanine-nucleotide exchange factor that activates Ras p21, was tested for its ability to couple to either tyrosine kinase or heterotrimeric G protein signal transduction pathways. Ras-GRF failed to bind the SH2 and SH3 containing adaptor protein Grb2, either in vitro or in vivo. Furthermore, Ras-GRF did not...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-05-18 00:00:00