Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative 'tumor progression' locus.

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newly established from human oral cancer patients. ZA had a point mutational activation at the 13th codon, this activation of c-...

journal_title：Oncogene

authors： Tadokoro K,Ueda M,Ohshima T,Fujita K,Rikimaru K,Takahashi N,Enomoto S,Tsuchida N

更新日期：1989-04-01 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...

journal_title：Oncogene

authors： Nakagawachi T,Soejima H,Urano T,Zhao W,Higashimoto K,Satoh Y,Matsukura S,Kudo S,Kitajima Y,Harada H,Furukawa K,Matsuzaki H,Emi M,Nakabeppu Y,Miyazaki K,Sekiguchi M,Mukai T

更新日期：2003-12-04 00:00:00

abstract：:We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...

journal_title：Oncogene

authors： Vousden KH,Jat PS

更新日期：1989-02-01 00:00:00

abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...

journal_title：Oncogene

authors： Bossi G,Mazzaro G,Porrello A,Crescenzi M,Soddu S,Sacchi A

更新日期：2004-01-15 00:00:00

abstract：:Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...

journal_title：Oncogene

authors： Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

更新日期：2006-02-09 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients, the promyelocytic leukemia protein PML is disrupted as are the nuclear bodies it forms. Disruption of PML and PML nuclear bodies in APL is linked to a loss of gr...

journal_title：Oncogene

authors： Topcu Z,Mack DL,Hromas RA,Borden KL

更新日期：1999-11-25 00:00:00

abstract：:DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of cyclobutane pyrimidine dimers (CPDs), and is regulated by p53 in human cells. We show that DDB2 is expressed in mouse tissues and demonstrate, using primary mouse epithelial cells, that mouse DDB2 is regulated by E2F tr...

journal_title：Oncogene

authors： Prost S,Lu P,Caldwell H,Harrison D

更新日期：2007-05-24 00:00:00

abstract：:The regulatory step in ubiquitin (Ub)-mediated protein degradation involves recognition and selection of the target substrate by an E3 Ub-ligase. E3 Ub-ligases evoke sophisticated mechanisms to regulate their activity temporally and spatially, including multiple post-translational modifications, combinatorial E3 Ub-li...

journal_title：Oncogene

authors： Ang XL,Wade Harper J

更新日期：2005-04-18 00:00:00

abstract：:We have previously reported that platelet-derived growth factor (PDGF) induced tyrosine phosphorylation of GTPase-activating protein (GAP) in intact quiescent fibroblasts under conditions in which insulin and basic fibroblast growth factor (bFGF) were ineffective (Molloy et al., 1988). In the present study, we have pr...

journal_title：Oncogene

authors： Heidaran MA,Molloy CJ,Pangelinan M,Choudhury GG,Wang LM,Fleming TP,Sakaguchi AY,Pierce JH

更新日期：1992-01-01 00:00:00

abstract：:Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...

journal_title：Oncogene

authors： Jandt E,Denner K,Kovalenko M,Ostman A,Böhmer FD

更新日期：2003-07-03 00:00:00

abstract：:The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) ...

journal_title：Oncogene

authors： Wen J,Li R,Lu Y,Shupnik MA

更新日期：2009-01-29 00:00:00

abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...

journal_title：Oncogene

authors： Ingvarsson S,Sundaresan S,Jin P,Francke U,Asker C,Sümegi J,Klein G,Sejersen T

更新日期：1988-12-01 00:00:00

abstract：:Breast carcinoma invasion is associated with prominent alterations in stromal fibroblasts. Carcinoma-associated fibroblasts (CAF) support and promote tumorigenesis, whereas normal mammary fibroblasts (NF) are thought to suppress tumor progression. Little is known about the difference in gene expression between CAF and...

journal_title：Oncogene

authors： Bauer M,Su G,Casper C,He R,Rehrauer W,Friedl A

更新日期：2010-03-25 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00

abstract：:Shb is a recently described Src homology 2 (SH2) domain-containing adaptor protein. Here we show that Shb is expressed in lymphoid tissues, and is recruited into signaling complexes upon activation of Jurkat T cells. Grb2 binds proline-rich motifs in Shb via its SH3 domains. As a result, a number of proteins detected ...

journal_title：Oncogene

authors： Welsh M,Songyang Z,Frantz JD,Trüb T,Reedquist KA,Karlsson T,Miyazaki M,Cantley LC,Band H,Shoelson SE

更新日期：1998-02-19 00:00:00

abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...

journal_title：Oncogene

authors： Seimiya H,Sawabe T,Inazawa J,Tsuruo T

更新日期：1995-05-04 00:00:00

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:The RNA-binding protein (RBP) RNPC1 is a target of the p53 family and forms a feedback regulatory loop with the p53 family proteins. The murine double minute-2 (MDM2) oncogene, a key negative regulator of p53, has a critical role in a variety of fundamental cellular processes. MDM2 expression is found to be regulated ...

journal_title：Oncogene

authors： Xu E,Zhang J,Chen X

更新日期：2013-04-25 00:00:00

abstract：:The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines ...

journal_title：Oncogene

authors： Kirchhoff S,Hauser H

更新日期：1999-06-24 00:00:00

abstract：:P53 wild-type and p53-null or mutant cells undergo a G(2)-phase cell-cycle arrest in response to ionizing radiation (IR). In this study we examined the effect of heat-shock protein 90 (HSP90) inhibitor, geldanamycin (GA), on IR-induced G(2) arrest in human colon adenocarcinoma cells with different p53 status. We show ...

journal_title：Oncogene

authors： Moran DM,Gawlak G,Jayaprakash MS,Mayar S,Maki CG

更新日期：2008-09-18 00:00:00

abstract：:A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. ...

journal_title：Oncogene

authors： Attwooll C,Tariq M,Harris M,Coyne JD,Telford N,Varley JM

更新日期：1999-12-09 00:00:00

abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

journal_title：Oncogene

authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

更新日期：2000-12-14 00:00:00

abstract：:The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-induced erythroleukemia and as tumor suppressor in acute myeloid leukemias. Moreover, Friend virus-induced eryth...

journal_title：Oncogene

authors： Tschan MP,Reddy VA,Ress A,Arvidsson G,Fey MF,Torbett BE

更新日期：2008-05-29 00:00:00

abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

journal_title：Oncogene

authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

更新日期：2004-07-22 00:00:00

abstract：:Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine...

journal_title：Oncogene

authors： Shirouzu M,Koide H,Fujita-Yoshigaki J,Oshio H,Toyama Y,Yamasaki K,Fuhrman SA,Villafranca E,Kaziro Y,Yokoyama S

更新日期：1994-08-01 00:00:00

abstract：:Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has to be elucidated. We have determined that human colon tumors exhibit decreased levels of mature let-7 isoforms and increased ex...

journal_title：Oncogene

authors： King CE,Wang L,Winograd R,Madison BB,Mongroo PS,Johnstone CN,Rustgi AK

更新日期：2011-10-06 00:00:00

abstract：:We have previously demonstrated the existence of a melanoma tumor suppressor gene(s) on the long arm of chromosome 11 through suppression of tumorigenicity assays. Although loss of heterozygosity studies also support this finding, only a large critical region (44 cM) has been identified to date on 11q22-25. To further...

journal_title：Oncogene

authors： Robertson GP,Goldberg EK,Lugo TG,Fountain JW

更新日期：1999-05-20 00:00:00

abstract：:Ewing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between EWS and FLI1 genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor expresses high levels of the CD99 membrane glycoprotein. It has been recently described that CD99 ...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,Bellanger D,Stern MH,Sastre-Garau X,Delattre O

更新日期：2013-08-15 00:00:00