Abstract:
:By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newly established from human oral cancer patients. ZA had a point mutational activation at the 13th codon, this activation of c-H-ras-1 being novel in human cancer cells, while HOC-313 appeared to have an activation at the 12th codon. In ZA, 16- to 32-fold amplification of the EGF receptor gene, c-erbB-1 and a few-fold amplification of c-myc were detected. The significance of these findings is discussed in relation to multistep carcinogenesis in human cells.
journal_name
Oncogenejournal_title
Oncogeneauthors
Tadokoro K,Ueda M,Ohshima T,Fujita K,Rikimaru K,Takahashi N,Enomoto S,Tsuchida Nsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
499-505issue
4eissn
0950-9232issn
1476-5594journal_volume
4pub_type
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