Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.

abstract：:Krüppel-like transcription factor 10 (KLF10), also named as TIEG1, plays essential roles in mediating transforming growth factor beta (TGFβ) signaling and has been shown to function as a tumor suppressor in multiple cancer types. However, its roles in mediating cancer progression in vivo have yet to be fully character...

journal_title：Oncogene

authors： Weng CC,Hawse JR,Subramaniam M,Chang VHS,Yu WCY,Hung WC,Chen LT,Cheng KH

更新日期：2017-09-28 00:00:00

abstract：:The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

journal_title：Oncogene

authors： Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

更新日期：1998-08-13 00:00:00

abstract：:A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoiet...

journal_title：Oncogene

authors： Shirsat NV,Pignolo RJ,Kreider BL,Rovera G

更新日期：1990-05-01 00:00:00

abstract：:TFAP2C/AP-2γ influences development of the mammary gland and regulates patterns of gene expression in luminal and HER2-amplified breast cancer. The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. To gain greater insight into oncogenic mechanisms r...

journal_title：Oncogene

authors： Park JM,Wu T,Cyr AR,Woodfield GW,De Andrade JP,Spanheimer PM,Li T,Sugg SL,Lal G,Domann FE,Zhang W,Weigel RJ

更新日期：2015-12-10 00:00:00

abstract：:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...

journal_title：Oncogene

authors： Nouvion AL,Thibaut J,Lohez OD,Venet S,Colas P,Gillet G,Lalle P

更新日期：2007-02-01 00:00:00

abstract：:Post-irradiation complications including thrombus formation result from increased procoagulant activity of vascular endothelial cells and elevated levels of von Willebrand factor (VWF) contribute to this process. We have previously demonstrated that irradiation induction of the VWF is mediated through interaction of N...

journal_title：Oncogene

authors： Peng Y,Stewart D,Li W,Hawkins M,Kulak S,Ballermann B,Jahroudi N

更新日期：2007-11-29 00:00:00

abstract：:Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...

journal_title：Oncogene

authors： Sánchez-Pérez T,Medema RH,López-Rivas A

更新日期：2015-01-29 00:00:00

abstract：:Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...

journal_title：Oncogene

authors： Matteucci E,Modora S,Simone M,Desiderio MA

更新日期：2003-06-26 00:00:00

abstract：:In lung cancer, frequent loss of one allele of chromosome 3p is seen in both small cell lung cancer and non-small cell lung cancer (NSCLC), providing evidence of tumor suppressor genes (TSGs) in this chromosomal region. The mechanism of Fus1 tumor suppressor activity is unknown. We have found that a Fus1 peptide inhib...

journal_title：Oncogene

authors： Lin J,Sun T,Ji L,Deng W,Roth J,Minna J,Arlinghaus R

更新日期：2007-10-25 00:00:00

abstract：:All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess direct...

journal_title：Oncogene

authors： Chen CF,Goyette P,Lohnes D

更新日期：2004-07-08 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5% of carriers after a long latent period. After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo by actions of encoded viral proteins, including Tax. However, leukemic cells frequently lack ...

journal_title：Oncogene

authors： Matsuoka M

更新日期：2003-08-11 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00

abstract：:BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP53 mutations, which ...

journal_title：Oncogene

authors： Böhringer M,Obermeier K,Griner N,Waldraff D,Dickinson E,Eirich K,Schindler D,Hagen M,Jerry DJ,Wiesmüller L

更新日期：2013-11-28 00:00:00

abstract：:Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers, particularly in lung cancer. Using a short-hairpin RNA approach, here we established that PKCɛ is required for non-small cell lung car...

journal_title：Oncogene

authors： Caino MC,Lopez-Haber C,Kim J,Mochly-Rosen D,Kazanietz MG

更新日期：2012-05-17 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...

journal_title：Oncogene

authors： Seth A,Robinson L,Panayiotakis A,Thompson DM,Hodge DR,Zhang XK,Watson DK,Ozato K,Papas TS

更新日期：1994-02-01 00:00:00

abstract：:In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...

journal_title：Oncogene

authors： Fabris L,Berton S,Citron F,D'Andrea S,Segatto I,Nicoloso MS,Massarut S,Armenia J,Zafarana G,Rossi S,Ivan C,Perin T,Vaidya JS,Avanzo M,Roncadin M,Schiappacassi M,Bristow RG,Calin G,Baldassarre G,Belletti B

更新日期：2016-09-15 00:00:00

abstract：:Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations in prostate tumorigenesis is largely unknown. In addition, there...

journal_title：Oncogene

authors： He Y,Johnson DT,Yang JS,Wu H,You S,Yoon J,Lee DH,Kim WK,Aldahl J,Le V,Hooker E,Yu EJ,Geradts J,Cardiff RD,Sun Z

更新日期：2019-09-01 00:00:00

abstract：:The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...

journal_title：Oncogene

authors： Sotoca AM,Prange KH,Reijnders B,Mandoli A,Nguyen LN,Stunnenberg HG,Martens JH

更新日期：2016-04-14 00:00:00

abstract：:Reovirus is a naturally oncolytic virus that preferentially replicates in Ras-transformed cells and is currently undergoing clinical trials as a cancer therapeutic. Ras transformation promotes reovirus oncolysis by enhancing virion disassembly during entry, viral progeny production, and virus release through apoptosis...

journal_title：Oncogene

authors： Garant KA,Shmulevitz M,Pan L,Daigle RM,Ahn DG,Gujar SA,Lee PW

更新日期：2016-02-11 00:00:00

abstract：:The Ets family of transcription factors is one of a growing number of master regulators of development. This family was originally defined by the presence of a conserved DNA binding domain, the Ets domain. To date, nearly 30 members of this family have been identified and implicated in a wide range of physiological an...

journal_title：Oncogene

authors： Bartel FO,Higuchi T,Spyropoulos DD

更新日期：2000-12-18 00:00:00

abstract：:Tumor cells, stromal cell compartment and the extracellular matrix (ECM) together generate a multifaceted tumor microenvironment. Matrix metalloproteinases and their tissue inhibitors (TIMPs) provide a means for tumor-stromal interaction during tumorigenesis. Among TIMPs, TIMP-3 is uniquely localized to the ECM and is...

journal_title：Oncogene

authors： Cruz-Muñoz W,Kim I,Khokha R

更新日期：2006-01-26 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a di...

journal_title：Oncogene

authors： Muppala S,Xiao R,Krukovets I,Verbovetsky D,Yendamuri R,Habib N,Raman P,Plow E,Stenina-Adognravi O

更新日期：2017-09-07 00:00:00

abstract：:LIM-kinase 2 (LIMK2) belongs to the LIMK family of proteins, which comprises LIMK1 and LIMK2. Both proteins regulate actin polymerization through phosphorylation and inactivation of the actin depolymerizing factor cofilin. In this study, we show that the level of LIMK2 protein is increased in neuroblastoma, BE(2)-C ce...

journal_title：Oncogene

authors： Po'uha ST,Shum MS,Goebel A,Bernard O,Kavallaris M

更新日期：2010-01-28 00:00:00

abstract：:The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few a...

journal_title：Oncogene

authors： Fedorenko IV,Gibney GT,Smalley KS

更新日期：2013-06-20 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines ...

journal_title：Oncogene

authors： Kirchhoff S,Hauser H

更新日期：1999-06-24 00:00:00

abstract：:Polyoma virus (Py) differs from other small DNA tumor viruses in not encoding a protein that inactivates p53. The complete Py early region encoding the large T-antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cells and REF52 cells, but PyMT, the main Py oncogene, by itse...

journal_title：Oncogene

authors： Lomax M,Fried M

更新日期：2001-08-16 00:00:00

abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

journal_title：Oncogene

authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

更新日期：2004-12-02 00:00:00