Polyoma virus disrupts ARF signaling to p53.

abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

journal_title：Oncogene

authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

更新日期：2009-02-26 00:00:00

abstract：:Rapamycin, a natural product inhibitor of the Raptor-mammalian target of rapamycin complex (mTORC1), is known to induce Protein kinase B (Akt/PKB) Ser-473 phosphorylation in a subset of human cancer cell lines through inactivation of S6K1, stabilization of insulin receptor substrate (IRS)-1, and increased signaling th...

journal_title：Oncogene

authors： Han EK,Leverson JD,McGonigal T,Shah OJ,Woods KW,Hunter T,Giranda VL,Luo Y

更新日期：2007-08-16 00:00:00

abstract：:It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...

journal_title：Oncogene

authors： Roy WJ Jr,Watson RH,Hitchcock A,Campbell IG

更新日期：1997-10-23 00:00:00

abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...

journal_title：Oncogene

authors： Ingvarsson S,Sundaresan S,Jin P,Francke U,Asker C,Sümegi J,Klein G,Sejersen T

更新日期：1988-12-01 00:00:00

abstract：:Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)...

journal_title：Oncogene

authors： Zheng R,Bailey E,Nguyen B,Yang X,Piloto O,Levis M,Small D

更新日期：2011-09-22 00:00:00

abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...

journal_title：Oncogene

authors： Nie J,Liu L,Xing G,Zhang M,Wei R,Guo M,Li X,Xie P,Li L,He F,Han W,Zhang L

更新日期：2014-07-10 00:00:00

abstract：:The short arm of chromosome 17 is one of the most frequently affected chromosomal regions in lung cancers, while there is solid evidence that the p53 gene at 17p13.1 is a target for frequent 17p deletions. In the present study, we re-evaluated 17p deletions in lung cancers by conducting a detailed analysis of the mini...

journal_title：Oncogene

authors： Konishi H,Takahashi T,Kozaki K,Yatabe Y,Mitsudomi T,Fujii Y,Sugiura T,Matsuda H,Takahashi T,Takahashi T

更新日期：1998-10-22 00:00:00

abstract：:Recently, constitutive activation of JAK kinases (JAKs) and/or signal transducers and activators of transcription (STATs) has been reported in growing numbers of human cancer cells as well as oncogene-transformed cells. JAB/SOCS-1 has been shown to be an intrinsic JAK tyrosine kinase inhibitor and to suppress the cyto...

journal_title：Oncogene

authors： Iwamoto T,Senga T,Naito Y,Matsuda S,Miyake Y,Yoshimura A,Hamaguchi M

更新日期：2000-09-28 00:00:00

abstract：:In order to assess the functional contribution of the human c-myc promoter region in the expression of the c-myc gene, transgenic mouse lines containing a bacterial lac Z gene encoding beta-galactosidase under the control of the human c-myc protooncogene promoter were generated. Transgenic mouse embryos heterozygous f...

journal_title：Oncogene

authors： Jones DE Jr,Cui DM,Miller DM

更新日期：1995-06-15 00:00:00

abstract：:In addition to breast and ovarian cancer in women, recent evidence suggests that germ-line mutations of the breast cancer susceptibility gene-1 (BRCA1) also confer an increased life-time risk for prostate cancer in male probands. However, it is not known if and how BRCA1 functions in prostate cancer. We stably express...

journal_title：Oncogene

authors： Fan S,Wang JA,Yuan RQ,Ma YX,Meng Q,Erdos MR,Brody LC,Goldberg ID,Rosen EM

更新日期：1998-06-11 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we identified S100 calcium-binding p...

journal_title：Oncogene

authors： Meng DF,Sun R,Liu GY,Peng LX,Zheng LS,Xie P,Lin ST,Mei Y,Qiang YY,Li CZ,Xu L,Peng XS,Hu H,Lang YH,Liu ZJ,Wang MD,Guo LL,Xie DH,Shu DT,Li HF,Luo FF,Niu XT,Huang BJ,Qian CN

更新日期：2020-07-01 00:00:00

abstract：:Due to its high proclivity to metastasize, and despite the recent development of targeted and immune therapy strategies, melanoma is still the deadliest form of skin cancer. Therefore, understanding the molecular mechanisms underlying melanoma invasion remains crucial. We previously characterized Tspan8 for its abilit...

journal_title：Oncogene

authors： El Kharbili M,Agaësse G,Barbollat-Boutrand L,Pommier RM,de la Fouchardière A,Larue L,Caramel J,Puisieux A,Berthier-Vergnes O,Masse I

更新日期：2019-05-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) control proliferation and differentiation through their ability to bind and/or phosphorylate intracellular substrates. The repertoire of substrates recruited by different RTK is largely overlapping. It is not clear, therefore, how a cell distinguishes among signals originating from dif...

journal_title：Oncogene

authors： Avantaggiato V,Torino A,Wong WT,Di Fiore PP,Simeone A

更新日期：1995-09-21 00:00:00

abstract：:Prostate cancer is one of the major causes of cancer-related death in the western world. Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the androgen receptor (AR) has been the norm of prostate cancer treatment. Despite early success to suppress prostate tumor growth, ADT eventually fail...

journal_title：Oncogene

authors： Niu Y,Chang TM,Yeh S,Ma WL,Wang YZ,Chang C

更新日期：2010-06-24 00:00:00

abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...

journal_title：Oncogene

authors： Ladendorff NE,Wu S,Lipsick JS

更新日期：2001-01-04 00:00:00

abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...

journal_title：Oncogene

authors： Choudhry H,Albukhari A,Morotti M,Haider S,Moralli D,Smythies J,Schödel J,Green CM,Camps C,Buffa F,Ratcliffe P,Ragoussis J,Harris AL,Mole DR

更新日期：2015-08-20 00:00:00

abstract：:We have recently developed an allele titration assay (ATA) to assess the sensitivity and influence of normal cell admixture in loss of heterozygosity (LOH) studies based on CA-repeat. The assay showed that these studies are biased by the size-dependent differential sensitivity of allele detection. Based on these data,...

journal_title：Oncogene

authors： Alimov A,Kost-Alimova M,Liu J,Li C,Bergerheim U,Imreh S,Klein G,Zabarovsky ER

更新日期：2000-03-09 00:00:00

abstract：:Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...

journal_title：Oncogene

authors： Kanda N,Seno H,Konda Y,Marusawa H,Kanai M,Nakajima T,Kawashima T,Nanakin A,Sawabu T,Uenoyama Y,Sekikawa A,Kawada M,Suzuki K,Kayahara T,Fukui H,Sawada M,Chiba T

更新日期：2004-06-17 00:00:00

abstract：:The stress-activated protein kinases (SAPKs), also known as c-Jun amino-terminal kinases (JNKs), are activated in response to diverse stimuli including DNA damage, heat shock, interleukin-1, tumor necrosis factor-alpha and Fas. Although all these inducers cause apoptosis, whether SAPK/JNK activation is required for ap...

journal_title：Oncogene

authors： Chauhan D,Pandey P,Ogata A,Teoh G,Treon S,Urashima M,Kharbanda S,Anderson KC

更新日期：1997-08-14 00:00:00

abstract：:Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppressed in HRAS-transfo...

journal_title：Oncogene

authors： Lund P,Weisshaupt K,Mikeska T,Jammas D,Chen X,Kuban RJ,Ungethüm U,Krapfenbauer U,Herzel HP,Schäfer R,Walter J,Sers C

更新日期：2006-08-10 00:00:00

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...

journal_title：Oncogene

authors： McCullough ML,Giovannucci EL

更新日期：2004-08-23 00:00:00

abstract：:The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...

journal_title：Oncogene

authors： Ceruti JM,Scassa ME,Fló JM,Varone CL,Cánepa ET

更新日期：2005-06-09 00:00:00

abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

journal_title：Oncogene

authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

更新日期：2006-12-14 00:00:00

abstract：:The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray expression analysis to evaluate the expression profiles of a unique pane...

journal_title：Oncogene

authors： Manos EJ,Kim ML,Kassis J,Chang PY,Wells A,Jones DA

更新日期：2001-05-17 00:00:00

abstract：:Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear. In this study, we show that overexpression of connexin43 (Cx43) suppressed proliferation of human osteosarcoma U2OS cells through inhibit...

journal_title：Oncogene

authors： Zhang YW,Morita I,Ikeda M,Ma KW,Murota S

更新日期：2001-07-12 00:00:00

abstract：:p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expres...

journal_title：Oncogene

authors： Nasr AF,Nutini M,Palombo B,Guerra E,Alberti S

更新日期：2003-03-20 00:00:00

abstract：:Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...

journal_title：Oncogene

authors： Haley JD,Hsuan JJ,Waterfield MD

更新日期：1989-03-01 00:00:00

abstract：:Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD family of calcium-calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and PKD3. PKD2 is activated by many stimuli including growth factors, phorbol esters, and G-protein-coupled receptor agonists. PKD2 participation to uncontroll...

journal_title：Oncogene

authors： Azoitei N,Cobbaut M,Becher A,Van Lint J,Seufferlein T

更新日期：2018-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes the potentially oncogenic HBx protein, which mainly functions as a transcriptional co-activator involving in multiple gene deregulations. However, mechanisms underlying HBx-mediated oncogenicity remain unc...

journal_title：Oncogene

authors： Wu CG,Salvay DM,Forgues M,Valerie K,Farnsworth J,Markin RS,Wang XW

更新日期：2001-06-21 00:00:00