S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1.

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:Treatment of quiescent Balb/3T3 clone A31-1-1 cells with 0.1-0.2 mM H2O2 in the presence of 1 microM insulin induced DNA synthesis 20-24 h later at almost the same level as that in cells treated with 10% serum. Treatment with 0.1-0.2 mM H2O2 alone did not induce DNA synthesis and was not toxic to the cells. Cell cycle...

journal_title：Oncogene

authors： Shibanuma M,Kuroki T,Nose K

更新日期：1990-07-01 00:00:00

abstract：:Understanding how disruption of differentiation contributes to the cancer cell phenotype is required to identify alterations essential for malignant transformation and provide experimental basis for their correction. We investigated whether primary quail neuroretina cells, transformed by a conditional v-Src mutant (QN...

journal_title：Oncogene

authors： Mateos S,Amarir S,Laugier D,Marx M,Calothy G

更新日期：2007-05-17 00:00:00

abstract：:Cancer cells harboring oncogenic BRaf mutants, but not oncogenic KRas mutants, are sensitive to MEK inhibitors (MEKi). The mechanism underlying the intrinsic resistance to MEKi in KRas-mutant cells is under intensive investigation. Here, we pursued this mechanism by live imaging of extracellular signal-regulated kinas...

journal_title：Oncogene

authors： Komatsu N,Fujita Y,Matsuda M,Aoki K

更新日期：2015-11-05 00:00:00

abstract：:Somatic RET mutations have been identified in a variable proportion (about 30-70%) of sporadic Medullary Thyroid Carcinoma (MTC) cases. They are represented by the Met918Thr substitution (exon 16) typical of Multiple Endocrine Neoplasia type 2B (MEN2B) and, to a lesser extent, by nucleotide changes occurring at one of...

journal_title：Oncogene

authors： Ceccherini I,Pasini B,Pacini F,Gullo M,Bongarzone I,Romei C,Santamaria G,Matera I,Mondellini P,Scopsi L,Pinchera A,Pierotti MA,Romeo G

更新日期：1997-05-29 00:00:00

abstract：:Colon cancer is the third leading cause of death from cancer worldwide with less than 10% survival rate at the late stage. Although mutations of certain genes have been implicated in familial colon cancer development, the etiology of the majority of colon cancer remains unknown. Herein, we identified TYRO3 as a potent...

journal_title：Oncogene

authors： Chien CW,Hou PC,Wu HC,Chang YL,Lin SC,Lin SC,Lin BW,Lee JC,Chang YJ,Sun HS,Tsai SJ

更新日期：2016-11-10 00:00:00

abstract：:To investigate the role of individual Jun proteins in cell growth and transformation, we have used a doxycycline-inducible retroviral vector to regulate their expression in rat fibroblasts. AP-1 complexes enriched with cJun and JunB result in morphological alterations and anchorage-independent cell growth consistent w...

journal_title：Oncogene

authors： Leaner VD,Kinoshita I,Birrer MJ

更新日期：2003-08-28 00:00:00

abstract：:The p160 nuclear receptor co-activators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are overexpressed in several tumors. We investigated the role of one member of this family on the sensitivity of cells to apoptosis. We observed that ove...

journal_title：Oncogene

authors： Colo GP,Rubio MF,Nojek IM,Werbajh SE,Echeverría PC,Alvarado CV,Nahmod VE,Galigniana MD,Costas MA

更新日期：2008-04-10 00:00:00

abstract：:The human cellular homolog of v-rel, the transforming gene of reticuloendotheliosis virus, strain T, was previously localized to 2 cent-2p13 by a combination of somatic cell hybrid and in situ hybridization analyses. In this study, we use translocation chromosome analysis to refine c-rel's genetic assignment to 2p12-2...

journal_title：Oncogene

authors： Brownell E,Fell HP,Tucker PW,Geurts van Kessel AH,Hagemeijer A,Rice NR

更新日期：1988-05-01 00:00:00

abstract：:Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...

journal_title：Oncogene

authors： Tada Y,Yamaguchi Y,Kinjo T,Song X,Akagi T,Takamura H,Ohta T,Yokota T,Koide H

更新日期：2015-02-05 00:00:00

abstract：:To achieve a better understanding of mechanisms that underlie hepatocarcinogenesis and to identify novel target molecules for diagnosis and therapy of hepatocellular carcinoma (HCC), we previously analysed gene-expression profiles of 20 HCC tissues on a cDNA microarray. Among the genes upregulated in the tumor tissues...

journal_title：Oncogene

authors： Silva FP,Hamamoto R,Furukawa Y,Nakamura Y

更新日期：2006-08-17 00:00:00

abstract：:We have established conditions for the immortalization of human fibroblasts by the large T antigen of the rodent virus polyoma. This allows the mechanism of immortalization to be studied, without interference by transformation events, in cells with relatively stable chromosomes. Large T antigen could immortalize human...

journal_title：Oncogene

authors： Strauss M,Hering S,Lubbe L,Griffin BE

更新日期：1990-08-01 00:00:00

abstract：:RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli...

journal_title：Oncogene

authors： Bren GD,Solan NJ,Miyoshi H,Pennington KN,Pobst LJ,Paya CV

更新日期：2001-11-22 00:00:00

abstract：:In both humans with long-standing ulcerative colitis and mouse models of colitis-associated carcinogenesis (CAC), tumors develop predominantly in the distal part of the large intestine but the biological basis of this intriguing pathology remains unknown. Herein we report intrinsic differences in gene expression betwe...

journal_title：Oncogene

authors： Gkouskou KK,Ioannou M,Pavlopoulos GA,Georgila K,Siganou A,Nikolaidis G,Kanellis DC,Moore S,Papadakis KA,Kardassis D,Iliopoulos I,McDyer FA,Drakos E,Eliopoulos AG

更新日期：2016-05-12 00:00:00

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:The Ste20-like kinase, SLK, is involved in the control of cell motility through its effects on actin reorganization and focal adhesion turnover. Here we investigated the role of SLK in chemotaxis downstream of the tyrosine kinase receptor, HER2/ErbB2/Neu, which is frequently overexpressed in human breast cancers. Our ...

journal_title：Oncogene

authors： Roovers K,Wagner S,Storbeck CJ,O'Reilly P,Lo V,Northey JJ,Chmielecki J,Muller WJ,Siegel PM,Sabourin LA

更新日期：2009-08-06 00:00:00

abstract：:Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor suppressor genes. Much of our understanding of tumor suppressor gene function is derived from experimental manipulations in cultured cells. Recently, however, the generation of mice with germ line tumor suppressor gene mutations...

journal_title：Oncogene

authors： Ghebranious N,Donehower LA

更新日期：1998-12-24 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tuberin is a widely expressed 180 kDa protein which exhibits specific GTP...

journal_title：Oncogene

authors： Wienecke R,Maize JC Jr,Shoarinejad F,Vass WC,Reed J,Bonifacino JS,Resau JH,de Gunzburg J,Yeung RS,DeClue JE

更新日期：1996-09-05 00:00:00

abstract：:Class I HLA expression is low in neuroblastoma tumours and cell lines. We have recently mapped a modifier of methylation for HLA-C (MEMO-1) to chromosomal bands 1p35-36.1, a region deleted in many neuroblastomas. Hypomethylation of HLA-C is strongly correlated with allelic loss of the MEMO-1 locus. Here, we show that ...

journal_title：Oncogene

authors： Cheng NC,Beitsma M,Chan A,Op den Camp I,Westerveld A,Pronk J,Versteeg R

更新日期：1996-10-17 00:00:00

abstract：:Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src. In the intrinsic pathway, RACK1 inhibits expression of anti-apoptotic Bcl-2 and Bcl-X(L), induces expre...

journal_title：Oncogene

authors： Mamidipudi V,Cartwright CA

更新日期：2009-12-17 00:00:00

abstract：:The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...

journal_title：Oncogene

authors： Smith AL,Iwanaga R,Drasin DJ,Micalizzi DS,Vartuli RL,Tan AC,Ford HL

更新日期：2012-12-13 00:00:00

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...

journal_title：Oncogene

authors： Bossi G,Mazzaro G,Porrello A,Crescenzi M,Soddu S,Sacchi A

更新日期：2004-01-15 00:00:00

abstract：:Two rare cases of chronic lymphocytic leukemia (CLL) in children, patients AS and LH, have been found to be associated with a unique chromosomal translocation, t(2;14)(p13;q32). Previous studies have shown the breakpoints of this translocation to be in the gamma 2 switch region of the Ig heavy-chain locus on chromosom...

journal_title：Oncogene

authors： Richardson AL,Humphries CG,Tucker PW

更新日期：1992-05-01 00:00:00

abstract：:Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...

journal_title：Oncogene

authors： Strano S,Dell'Orso S,Di Agostino S,Fontemaggi G,Sacchi A,Blandino G

更新日期：2007-04-02 00:00:00

abstract：:Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain inadequate. An increased understanding of the molecular biology of lung cancer biology is required to develop more effective new therapies. In this report, we show that ...

journal_title：Oncogene

authors： Uematsu K,He B,You L,Xu Z,McCormick F,Jablons DM

更新日期：2003-10-16 00:00:00

abstract：:The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM, we have assessed th...

journal_title：Oncogene

authors： Mahtouk K,Cremer FW,Rème T,Jourdan M,Baudard M,Moreaux J,Requirand G,Fiol G,De Vos J,Moos M,Quittet P,Goldschmidt H,Rossi JF,Hose D,Klein B

更新日期：2006-11-16 00:00:00