Abstract:
:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemotherapeutic agents. In the present study, we took advantage of the peptide aptamer strategy to target Nr-13, a Bcl-2 antiapoptotic protein involved in neoplastic transformation by the Rous sarcoma virus. We isolated peptide aptamers that behave as Nr-13 regulators, in vitro and in mammalian cells in culture. Some of these aptamers have potential proapoptotic activities. These data suggest that peptide aptamers targeting the Bcl-2 family of apoptosis inhibitors may be useful for the development of anticancer molecules.
journal_name
Oncogenejournal_title
Oncogeneauthors
Nouvion AL,Thibaut J,Lohez OD,Venet S,Colas P,Gillet G,Lalle Pdoi
10.1038/sj.onc.1209832subject
Has Abstractpub_date
2007-02-01 00:00:00pages
701-10issue
5eissn
0950-9232issn
1476-5594pii
1209832journal_volume
26pub_type
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