The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin.

abstract：:The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant ...

journal_title：Oncogene

authors： Gery S,Koeffler HP

更新日期：2013-06-27 00:00:00

abstract：:Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunoprecipitation of fusion protein or in vitro translated protein, respect...

journal_title：Oncogene

authors： Drané P,Barel M,Balbo M,Frade R

更新日期：1997-12-18 00:00:00

abstract：:Murine double minute (MDM2) binding protein (MTBP) has been implicated in cancer progression. Here, we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice, but significantly inhibite...

journal_title：Oncogene

authors： Agarwal N,Adhikari AS,Iyer SV,Hekmatdoost K,Welch DR,Iwakuma T

更新日期：2013-01-24 00:00:00

abstract：:Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...

journal_title：Oncogene

authors： Maddika S,Wiechec E,Ande SR,Poon IK,Fischer U,Wesselborg S,Jans DA,Schulze-Osthoff K,Los M

更新日期：2008-05-08 00:00:00

abstract：:Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...

journal_title：Oncogene

authors： Kosa P,Szabo R,Molinolo AA,Bugge TH

更新日期：2012-08-09 00:00:00

abstract：:To investigate a possible role for c-Jun homodimers in c-Jun-mediated transformation, we designed two chimeric c-Jun derivatives, called c-Juneb1 and c-Jungcn4. In these chimeric derivatives the natural dimerization domain of c-Jun was replaced by the heterologous homodimerization domain of the Epstein-Barr virus EB1 ...

journal_title：Oncogene

authors： Castellazzi M,Loiseau L,Piu F,Sergeant A

更新日期：1993-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...

journal_title：Oncogene

authors： Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG,Lu PJ

更新日期：2009-09-24 00:00:00

abstract：:The mouse pancreatic amylase Amy-2.2 gene was fused to the structural gene for SV40 T antigen, and 51 independent transgenic founder mice carrying the fusion gene were generated. The majority of the founders and 100% of their offspring in the derived transgenic lines developed pancreatic acinar cell carcinomas and sto...

journal_title：Oncogene

authors： Ceci JD,Kovatch RM,Swing DA,Jones JM,Snow CM,Rosenberg MP,Jenkins NA,Copeland NG,Meisler MH

更新日期：1991-02-01 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00

abstract：:cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein...

journal_title：Oncogene

authors： Matsui M,Tokuhara M,Konuma Y,Nomura N,Ishizaki R

更新日期：1990-03-01 00:00:00

abstract：:Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular cues and play a critica...

journal_title：Oncogene

authors： McKay MM,Morrison DK

更新日期：2007-05-14 00:00:00

abstract：:The understanding of the organisation of cell cycle events is of utmost importance to devise effective therapeutic strategies for cancer. In this article we gather evidences from the literature in support of a system model of the cell cycle, in which a growth-sensitive threshold controls entry into S phase and the seq...

journal_title：Oncogene

authors： Alberghina L,Porro D,Cazzador L

更新日期：2001-03-01 00:00:00

abstract：:Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppr...

journal_title：Oncogene

authors： Wang J,Ding S,Duan Z,Xie Q,Zhang T,Zhang X,Wang Y,Chen X,Zhuang H,Lu F

更新日期：2016-03-31 00:00:00

abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...

journal_title：Oncogene

authors： Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

更新日期：2019-04-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS). Seventy-five percent of ARMS harbor reciprocal chromosomal translocations leading to fusion genes of the forkhead transcriptio...

journal_title：Oncogene

authors： Zibat A,Missiaglia E,Rosenberger A,Pritchard-Jones K,Shipley J,Hahn H,Fulda S

更新日期：2010-12-02 00:00:00

abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...

journal_title：Oncogene

authors： Bougeret C,Rothhut B,Jullien P,Fischer S,Benarous R

更新日期：1993-05-01 00:00:00

abstract：:A mouse gene encoding a receptor tyrosine kinase, designated Embryonic receptor kinase (EmRK2), was isolated from embryoid bodies (EBs) generated by differentiating embryonic stem (ES) cells in culture for 6 days. Sequence analysis of EmRK2 cDNA clones predicts a receptor with a 755 amino acid extracellular region wit...

journal_title：Oncogene

authors： Choi K,Wall C,Hanratty R,Keller G

更新日期：1994-04-01 00:00:00

abstract：:Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosi...

journal_title：Oncogene

authors： Busacca S,Law EW,Powley IR,Proia DA,Sequeira M,Le Quesne J,Klabatsa A,Edwards JM,Matchett KB,Luo JL,Pringle JH,El-Tanani M,MacFarlane M,Fennell DA

更新日期：2016-03-24 00:00:00

abstract：:To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...

journal_title：Oncogene

authors： Bangur CS,Switzer A,Fan L,Marton MJ,Meyer MR,Wang T

更新日期：2002-05-23 00:00:00

abstract：:CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...

journal_title：Oncogene

authors： Ward Y,Lake R,Martin PL,Killian K,Salerno P,Wang T,Meltzer P,Merino M,Cheng SY,Santoro M,Garcia-Rostan G,Kelly K

更新日期：2013-05-30 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:Epidemiological studies have demonstrated a close association of type 2 diabetes and hepatocellular carcinoma (HCC). Exenatide (Ex-4), a potent diabetes drug targeting glucagon-like peptide-1 receptor (GLP-1R), is protective against non-alcoholic fatty liver disease (NAFLD). However, the Ex-4 function and GLP-1R statu...

journal_title：Oncogene

authors： Zhou M,Mok MT,Sun H,Chan AW,Huang Y,Cheng AS,Xu G

更新日期：2017-07-20 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression. Primarily known as a regulator of neuronal guidance and angiogenesis, NRP1 is also expressed in multiple human malignancies, where it promotes tumor angiogenesis. However, non-angiogenic roles of NRP1 in tumor progr...

journal_title：Oncogene

authors： Tse BWC,Volpert M,Ratther E,Stylianou N,Nouri M,McGowan K,Lehman ML,McPherson SJ,Roshan-Moniri M,Butler MS,Caradec J,Gregory-Evans CY,McGovern J,Das R,Takhar M,Erho N,Alshalafa M,Davicioni E,Schaeffer EM,Jenkins RB

更新日期：2017-06-15 00:00:00

abstract：:The myc proto-oncogenes are transcription factors that directly regulate the expression of other genes, by binding to the specific DNA sequence, CACGTG. Among the target genes for c-Myc regulation are ECA39, p53, ornithine decarboxylase (ODC), alpha-prothymosin and Cdc25A. In this study we examined the involvement of ...

journal_title：Oncogene

authors： Ben-Yosef T,Yanuka O,Halle D,Benvenisty N

更新日期：1998-07-16 00:00:00

abstract：:High-throughput, human cell-based applications of RNA-mediated interference (RNAi) have emerged in recent years as perhaps the most powerful of a 'second wave' of functional genomics technologies. The available reagents and methodologies for RNAi screening studies now enable a wide range of different scopes and scales...

journal_title：Oncogene

authors： Sachse C,Echeverri CJ

更新日期：2004-11-01 00:00:00

abstract：:Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...

journal_title：Oncogene

authors： Dirmeier U,Hoffmann R,Kilger E,Schultheiss U,Briseño C,Gires O,Kieser A,Eick D,Sugden B,Hammerschmidt W

更新日期：2005-03-03 00:00:00

abstract：:Members of the src family of tyrosine kinases are composed of amino acid sequences which can be divided into three regions: the unique amino-terminal 80 residues; the next 180 residues of conserved but non-catalytic sequence; and the catalytic carboxy-terminal half of the molecule. To characterize the elements that re...

journal_title：Oncogene

authors： Espino PC,Chou WY,Smith AE,Cheng SH

更新日期：1992-02-01 00:00:00

abstract：:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...

journal_title：Oncogene

authors： Teshima K,Nara M,Watanabe A,Ito M,Ikeda S,Hatano Y,Oshima K,Seto M,Sawada K,Tagawa H

更新日期：2014-04-24 00:00:00

abstract：:Reversible acetylation on protein lysine residues has been shown to regulate the function of both nuclear proteins such as histones and p53 and cytoplasmic proteins such as alpha-tubulin. To identify novel acetylated proteins, we purified several proteins by the affinity to an anti-acetylated-lysine antibody from cell...

journal_title：Oncogene

authors： Shimazu T,Komatsu Y,Nakayama KI,Fukazawa H,Horinouchi S,Yoshida M

更新日期：2006-11-30 00:00:00