Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma.

abstract：:The aspartic protease cathepsin D (cath-D) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, cath-D is translocated to the cytosol. Because cath-D is one of the lysosomal enzymes that requires a more acidic pH to be proteolytically active r...

journal_title：Oncogene

authors： Beaujouin M,Baghdiguian S,Glondu-Lassis M,Berchem G,Liaudet-Coopman E

更新日期：2006-03-23 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of hu...

journal_title：Oncogene

authors： Kawakami Y,Furue M,Kawakami T

更新日期：1989-03-01 00:00:00

abstract：:A selective switch from expression of Shc1 gene to Shc3 occurs with maturation of neuronal precursors into postmitotic neurons. Previous studies showed that in the embryo, Shc1 is maximally expressed in dividing CNS stem cells while it is silenced in mature neurons, where it is replaced by Shc3. Under normal condition...

journal_title：Oncogene

authors： Magrassi L,Conti L,Lanterna A,Zuccato C,Marchionni M,Cassini P,Arienta C,Cattaneo E

更新日期：2005-08-04 00:00:00

abstract：:p27Kip1 is a regulator of the mammalian cell cycle and a putative tumor suppressor. Distinct altered patterns of p27Kip1 protein expression are found in a variety of human carcinomas, and p27Kip1 expression levels usually correlate directly with disease-free survival. The mechanism(s) by which p27Kip1 expression is re...

journal_title：Oncogene

authors： Worm J,Bartkova J,Kirkin AF,Straten P,Zeuthen J,Bartek J,Guldberg P

更新日期：2000-10-19 00:00:00

abstract：:Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function th...

journal_title：Oncogene

authors： Itahana Y,Han R,Barbier S,Lei Z,Rozen S,Itahana K

更新日期：2015-04-02 00:00:00

abstract：:DNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and recent research implicates alterations in chromatin structure as the mechanistic basis for this repressi...

journal_title：Oncogene

authors： Karpf AR,Jones DA

更新日期：2002-08-12 00:00:00

abstract：:Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lin...

journal_title：Oncogene

authors： Saeki N,Kim DH,Usui T,Aoyagi K,Tatsuta T,Aoki K,Yanagihara K,Tamura M,Mizushima H,Sakamoto H,Ogawa K,Ohki M,Shiroishi T,Yoshida T,Sasaki H

更新日期：2007-10-04 00:00:00

abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

journal_title：Oncogene

authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

更新日期：2004-12-02 00:00:00

abstract：:Shb is a recently described Src homology 2 (SH2) domain-containing adaptor protein. Here we show that Shb is expressed in lymphoid tissues, and is recruited into signaling complexes upon activation of Jurkat T cells. Grb2 binds proline-rich motifs in Shb via its SH3 domains. As a result, a number of proteins detected ...

journal_title：Oncogene

authors： Welsh M,Songyang Z,Frantz JD,Trüb T,Reedquist KA,Karlsson T,Miyazaki M,Cantley LC,Band H,Shoelson SE

更新日期：1998-02-19 00:00:00

abstract：:Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...

journal_title：Oncogene

authors： Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

更新日期：2010-10-07 00:00:00

abstract：:Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. M...

journal_title：Oncogene

authors： Page G,Kögel D,Rangnekar V,Scheidtmann KH

更新日期：1999-12-02 00:00:00

abstract：:Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...

journal_title：Oncogene

authors： Dong Y,Richards JA,Gupta R,Aung PP,Emley A,Kluger Y,Dogra SK,Mahalingam M,Wajapeyee N

更新日期：2014-09-18 00:00:00

abstract：:An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...

journal_title：Oncogene

authors： Prévostel C,Alvaro V,de Boisvilliers F,Martin A,Jaffiol C,Joubert D

更新日期：1995-08-17 00:00:00

abstract：:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...

journal_title：Oncogene

authors： Givol I,Givol D,Hughes SH

更新日期：1998-06-18 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...

journal_title：Oncogene

authors： Li H,Seth A

更新日期：2004-03-11 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:p53 plays a central role in the induction of apoptosis of spermatogonia in response to ionizing radiation. In p53(-/-) testes, however, spermatogonial apoptosis still can be induced by ionizing radiation, so p53 independent apoptotic pathways must exist in spermatogonia. Here we show that the p53 homologues p63 and p7...

journal_title：Oncogene

authors： Hamer G,Gademan IS,Kal HB,de Rooij DG

更新日期：2001-07-19 00:00:00

abstract：:Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...

journal_title：Oncogene

authors： Chen H,Cai W,Chu ESH,Tang J,Wong CC,Wong SH,Sun W,Liang Q,Fang J,Sun Z,Yu J

更新日期：2017-08-01 00:00:00

abstract：:Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...

journal_title：Oncogene

authors： Ohno S,Naito Y,Mukai S,Yabuta N,Nojima H

更新日期：2015-12-03 00:00:00

abstract：:We have shown that one of the principle mechanisms of chemotherapy resistance involves the activation of nuclear factor kappa-B (NF-kappaB). In an effort to identify NF-kappaB-regulated chemotherapy response genes, we performed a microarray assay and observed that heparin-binding EGF-like growth factor (HB-EGF) was si...

journal_title：Oncogene

authors： Wang F,Liu R,Lee SW,Sloss CM,Couget J,Cusack JC

更新日期：2007-03-29 00:00:00

abstract：:Guanine nucleotide exchange factors from the Dbl family are proto-oncogenic proteins that activate small GTPases of the Rho family. Here we report the characterization of GEF720, a novel Dbl-like protein related to p115Rho-GEF. GEF720 activated RhoA both in our recently developed Yeast Exchange Assay and in biochemica...

journal_title：Oncogene

authors： De Toledo M,Coulon V,Schmidt S,Fort P,Blangy A

更新日期：2001-11-01 00:00:00

abstract：:Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its antitumor effect and mechanisms are context dependent and its activity has never been systematically studied in bladder cancer treatment. We used mouse models, cu...

journal_title：Oncogene

authors： Wu M,Sheng L,Cheng M,Zhang H,Jiang Y,Lin S,Liang Y,Zhu F,Liu Z,Zhang Y,Zhang X,Gao Q,Chen D,Li J,Li Y

更新日期：2019-07-01 00:00:00

abstract：:RET/PTC1 is a chimeric oncogene created by the fusion of the tyrosine kinase domain of RET to the 5'-terminal region of another gene named H4. So far, this oncogene has been found activated only in human papillary thyroid carcinomas. In order to investigate its transforming properties in vivo, we have produced transge...

journal_title：Oncogene

authors： Portella G,Salvatore D,Botti G,Cerrato A,Zhang L,Mineo A,Chiappetta G,Santelli G,Pozzi L,Vecchio G,Fusco A,Santoro M

更新日期：1996-11-07 00:00:00

abstract：:Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers, particularly in lung cancer. Using a short-hairpin RNA approach, here we established that PKCɛ is required for non-small cell lung car...

journal_title：Oncogene

authors： Caino MC,Lopez-Haber C,Kim J,Mochly-Rosen D,Kazanietz MG

更新日期：2012-05-17 00:00:00

abstract：:We have previously reported that platelet-derived growth factor (PDGF) induced tyrosine phosphorylation of GTPase-activating protein (GAP) in intact quiescent fibroblasts under conditions in which insulin and basic fibroblast growth factor (bFGF) were ineffective (Molloy et al., 1988). In the present study, we have pr...

journal_title：Oncogene

authors： Heidaran MA,Molloy CJ,Pangelinan M,Choudhury GG,Wang LM,Fleming TP,Sakaguchi AY,Pierce JH

更新日期：1992-01-01 00:00:00