The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

abstract：:Birt-Hogg-Dubé syndrome (BHD) is a rare, inherited genodermatosis characterized by hair follicle hamartomas, kidney tumors and spontaneous pneumothorax. The BHD locus was mapped to chromosome 17p11.2 by linkage analysis, and germline mutations in a novel gene (BHD) were identified in a panel of BHD families. Using RNA...

journal_title：Oncogene

authors： Singh SR,Zhen W,Zheng Z,Wang H,Oh SW,Liu W,Zbar B,Schmidt LS,Hou SX

更新日期：2006-09-28 00:00:00

abstract：:The role of specificity protein 1 (Sp1) in controlling gene expression in lung tumor development and metastasis is not well understood. In this study, we showed that the Sp1 level was highly increased and required for lung tumor growth in transgenic mice bearing Kras-induced lung tumors under the control of doxycyclin...

journal_title：Oncogene

authors： Hsu TI,Wang MC,Chen SY,Yeh YM,Su WC,Chang WC,Hung JJ

更新日期：2012-08-30 00:00:00

abstract：:The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its beha...

journal_title：Oncogene

authors： Quimby BB,Yong-Gonzalez V,Anan T,Strunnikov AV,Dasso M

更新日期：2006-05-18 00:00:00

abstract：:BRCA2 is a breast cancer susceptibility gene. Germline mutations of BRCA2 account for about 10-30% of familial breast cancer cases. Consistent with its tumor-suppressor activity, BRCA2 plays an important role in DNA repair. To assess the susceptibility of carriers of mutant BRCA2 to tumorigenesis induced by DNA-damagi...

journal_title：Oncogene

authors： Yan DH,Wen Y,Su LK,Xia W,Wang SC,Zhang S,Gan L,Lee DF,Spohn B,Frey JA,Hortobagyi GN,Hung MC

更新日期：2004-03-11 00:00:00

abstract：:Clonogenic murine B cell precursors are normally ultrasensitive to apoptosis following genotoxic exposure in vitro but can be protected by expression of an E mu-BCL-2 transgene. Such exposures are likely to be mutagenic. This in turn suggests that a level of in vivo genotoxic exposure that usually has minimal patholog...

journal_title：Oncogene

authors： Gibbons DL,MacDonald D,McCarthy KP,Cleary HJ,Plumb M,Wright EG,Greaves MF

更新日期：1999-07-01 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:p73 encodes multiple functionally distinct isoforms. Proapoptotic TAp73 isoforms contain a transactivation (TA) domain, and like p53, have tumor suppressor properties and are activated by chemotherapies to induce cell death. In contrast, antiapoptotic DeltaNp73 isoforms lack the TA domain and are dominant-negative inh...

journal_title：Oncogene

authors： Lau LM,Wolter JK,Lau JT,Cheng LS,Smith KM,Hansford LM,Zhang L,Baruchel S,Robinson F,Irwin MS

更新日期：2009-05-14 00:00:00

abstract：:To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...

journal_title：Oncogene

authors： Rudolph B,Hueber AO,Evan GI

更新日期：2001-03-08 00:00:00

abstract：:Ras-GRF, a guanine-nucleotide exchange factor that activates Ras p21, was tested for its ability to couple to either tyrosine kinase or heterotrimeric G protein signal transduction pathways. Ras-GRF failed to bind the SH2 and SH3 containing adaptor protein Grb2, either in vitro or in vivo. Furthermore, Ras-GRF did not...

journal_title：Oncogene

authors： Shou C,Wurmser A,Suen KL,Barbacid M,Feig LA,Ling K

更新日期：1995-05-18 00:00:00

abstract：:The trans-activator protein, tax, from the human T leukemia virus type 1 (HTLV-1) trans-activates both viral and cellular genes. It has previously been shown that granulocyte macrophage-colony stimulating factor (GM-CSF) is constitutively expressed in HTLV-1 infected cells and in cells artificially expressing tax. We ...

journal_title：Oncogene

authors： Himes SR,Coles LS,Katsikeros R,Lang RK,Shannon MF

更新日期：1993-12-01 00:00:00

abstract：:The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that...

journal_title：Oncogene

authors： Feres KJ,Ischenko I,Hayman MJ

更新日期：2009-01-15 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...

journal_title：Oncogene

authors： Mishra L,Tully RE,Monga SP,Yu P,Cai T,Makalowski W,Mezey E,Pavan WJ,Mishra B

更新日期：1997-11-06 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and multiple evidence has confirmed that C5a production is elevated in NSCLC microenvironment. Although NSCLC cell proliferation induced by C5a has been reported, the involved mechanism has not been elucidated. In this study, we examined the pr...

journal_title：Oncogene

authors： Zhao C,Li Y,Qiu W,He F,Zhang W,Zhao D,Zhang Z,Zhang E,Ma P,Liu Y,Ma L,Yang F,Wang Y,Shu Y

更新日期：2018-08-01 00:00:00

abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

journal_title：Oncogene

authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

更新日期：2003-05-08 00:00:00

abstract：:c-Myc drives uncontrolled cell proliferation in various human cancers. However, in mouse embryo fibroblasts (MEFs), c-Myc also induces apoptosis by activating the p19Arf tumor suppressor pathway. Tbx2, a transcriptional repressor of p19Arf, can collaborate with c-Myc by suppressing apoptosis. MEFs overexpressing c-Myc...

journal_title：Oncogene

authors： Taghavi P,Verhoeven E,Jacobs JJ,Lambooij JP,Stortelers C,Tanger E,Moolenaar WH,van Lohuizen M

更新日期：2008-11-20 00:00:00

abstract：:The efficacy of anticancer therapy is limited by the development of drug resistance. While the role of p53 in the intrinsic sensitivity of human cancer cells to paclitaxel (PTX) remains controversial, its role in acquired paclitaxel resistance has never been addressed. In this study we examined the p53 status of three...

journal_title：Oncogene

authors： Giannakakou P,Poy G,Zhan Z,Knutsen T,Blagosklonny MV,Fojo T

更新日期：2000-06-22 00:00:00

abstract：:Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain inadequate. An increased understanding of the molecular biology of lung cancer biology is required to develop more effective new therapies. In this report, we show that ...

journal_title：Oncogene

authors： Uematsu K,He B,You L,Xu Z,McCormick F,Jablons DM

更新日期：2003-10-16 00:00:00

abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

journal_title：Oncogene

authors： Zhang Y,Wang Z,Li X,Magnuson NS

更新日期：2008-08-14 00:00:00

abstract：:The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seventeen exons distrib...

journal_title：Oncogene

authors： McIlhatton MA,Burrows JF,Donaghy PG,Chanduloy S,Johnston PG,Russell SE

更新日期：2001-09-13 00:00:00

abstract：:The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction of neovascularization is a decisive step in tumor progression, since the growth of solid tumors is limited by nutrient and oxygen supply. Hypoxia is the critical factor that induces transcription of the hypoxia...

journal_title：Oncogene

authors： Wen Y,Zhou X,Lu M,He M,Tian Y,Liu L,Wang M,Tan W,Deng Y,Yang X,Mayer MP,Zou F,Chen X

更新日期：2019-03-01 00:00:00

abstract：:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...

journal_title：Oncogene

authors： Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

更新日期：2012-08-02 00:00:00

abstract：:Mutation induction in directly exposed cells is currently regarded as the main component of the genetic risk of ionizing radiation for humans. However, recent data on the transgenerational increases in mutation rates in the offspring of irradiated parents indicate that the genetic risk could be greater than predicted ...

journal_title：Oncogene

authors： Barber RC,Hickenbotham P,Hatch T,Kelly D,Topchiy N,Almeida GM,Jones GD,Johnson GE,Parry JM,Rothkamm K,Dubrova YE

更新日期：2006-11-30 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

journal_title：Oncogene

authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

更新日期：2017-03-30 00:00:00

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00

abstract：:The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subun...

journal_title：Oncogene

authors： von Morgen P,Burdova K,Flower TG,O'Reilly NJ,Boulton SJ,Smerdon SJ,Macurek L,Hořejší Z

更新日期：2017-08-24 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors; however, the molecular bases of their oncogenic properties are largely unknown. As TF activities are difficult to inhibit directly with small molecules, the genes and pathways the...

journal_title：Oncogene

authors： Sulahian R,Casey F,Shen J,Qian ZR,Shin H,Ogino S,Weir BA,Vazquez F,Liu XS,Hahn WC,Bass AJ,Chan V,Shivdasani RA

更新日期：2014-12-04 00:00:00