当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.

Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.

Abstract：

:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired integrin endocytosis, because of the loss of Rab21 small GTPase or mutations in the integrin β-subunit cytoplasmic tail, induces failure of cytokinesis in vitro. Here, we describe that repeatedly failed cytokinesis, because of impaired traffic, is sufficient to trigger the generation of aneuploid cells, which display characteristics of oncogenic transformation in vitro and are tumorigenic in vivo. Furthermore, in an in vivo mouse xenograft model, non-transformed cells with impaired integrin traffic formed tumors with a long latency. More detailed investigation of these tumors revealed that the tumor cells were aneuploid. Therefore, abnormal integrin traffic was linked with generation of aneuploidy and cell transformation also in vivo. In human prostate and ovarian cancer samples, downregulation of Rab21 correlates with increased malignancy. Loss-of-function experiments demonstrate that long-term depletion of Rab21 is sufficient to induce chromosome number aberrations in normal human epithelial cells. These data are the first to demonstrate that impaired integrin traffic is sufficient to induce conversion of non-transformed cells to tumorigenic cells in vitro and in vivo.

journal_name

Oncogene

journal_title

Oncogene

authors

Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

doi

10.1038/onc.2011.527

subject

Has Abstract

pub_date

2012-08-02 00:00:00

pages

3597-606

issue

31

eissn

0950-9232

issn

1476-5594

pii

onc2011527

journal_volume

31

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in an LNCaP model.

    abstract：:Transcriptional silencing of antitumor genes via CpG island methylation could be a mechanism mediating prostate cancer (PCa) progression from an androgen-sensitive (AS) to an androgen-insensitive (AI) state. We have used the methylation-sensitive restriction fingerprinting (MSRF) technique to identify novel CpG-rich s...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207076

    authors： Wu M,Ho SM

    更新日期：2004-01-08 00:00:00

  • Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains.

    abstract：:Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and RNA sequencing in a patient with glioblastoma multiforme to identify a rearr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-1021-1

    authors： Weinberg F,Griffin R,Fröhlich M,Heining C,Braun S,Spohr C,Iconomou M,Hollek V,Röring M,Horak P,Kreutzfeldt S,Warsow G,Hutter B,Uhrig S,Neumann O,Reuss D,Heiland DH,von Kalle C,Weichert W,Stenzinger A,Brors B,Gli

    更新日期：2020-01-01 00:00:00

  • Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms.

    abstract：:Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may incl...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206637

    authors： De Falco G,Bellan C,Lazzi S,Claudio P,La Sala D,Cinti C,Tosi P,Giordano A,Leoncini L

    更新日期：2003-09-18 00:00:00

  • Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency.

    abstract：:Mutations in mismatch repair (MMR) genes result in microsatellite instability (MSI) and early onset of colorectal cancer. To get mechanistic insights into the time scale, sequence and frequency of intestinal stem cell (ISC) transformation, we quantified MSI and growth characteristics of organoids of Msh2-deficient and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.429

    authors： Keysselt K,Kreutzmann T,Rother K,Kerner C,Krohn K,Przybilla J,Buske P,Löffler-Wirth H,Loeffler M,Galle J,Aust G

    更新日期：2017-05-11 00:00:00

  • Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.

    abstract：:Binding partners of the Src homology domains of Vav-1 were characterized by a two-hybrid screening of a Jurkat cell cDNA library. One of the isolated clones encoded a new protein named VIK that belongs to the Kruppel-like zinc-finger gene family. Genome mapping showed that a single gene positioned at chromosome 7q22.1...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208043

    authors： Houlard M,Romero-Portillo F,Germani A,Depaux A,Regnier-Ricard F,Gisselbrecht S,Varin-Blank N

    更新日期：2005-01-06 00:00:00

  • Functional interactions within adenovirus E1A protein complexes.

    abstract：:The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb tumor suppressor and a related p107 species, p130 and p300 proteins, and cyclin A (p60cycA). Extensive quantitative analyses using E1A deletion mutants identified ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Barbeau D,Charbonneau R,Whalen SG,Bayley ST,Branton PE

    更新日期：1994-02-01 00:00:00

  • Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.

    abstract：:Rad51 protein plays a pivotal role in homologous recombination (HR), which is involved in double-strand break repair and in genome maintenance. Despite interactions with tumor suppressor proteins, the role of mammalian Rad51 and more generally of HR in tumor prevention is not clearly established. Indeed, both high and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206998

    authors： Bertrand P,Lambert S,Joubert C,Lopez BS

    更新日期：2003-10-23 00:00:00

  • Expression of proto-oncogenes in embryonic, adult, and transformed tissue of Xiphophorus (Teleostei: Poeciliidae).

    abstract：:In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the no...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Mäueler W,Raulf F,Schartl M

    更新日期：1988-05-01 00:00:00

  • Induction of p21Waf1/Cip1 by TNFalpha requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells.

    abstract：:The Ewing family of tumors is characterized by recurrent reciprocal translocations that generate chimeric proteins, either EWS - FLI-1 or EWS - ERG. These proteins are potent transcriptional activators and are responsible for maintaining the oncogenic properties of tumor cells. Since apoptosis appears to be the main m...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203246

    authors： Javelaud D,Wietzerbin J,Delattre O,Besançon F

    更新日期：2000-01-06 00:00:00

  • The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation.

    abstract：:Inter-alpha-trypsin inhibitors (ITIs) are protease inhibitors stabilizing the extracellular matrix. ITIs consist of one light (bikunin) and two heavy chains (ITIHs). We have recently characterized ITIH5, a novel member of the ITIH gene family, and showed that its messenger RNA is lost in a high proportion of breast tu...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210669

    authors： Veeck J,Chorovicer M,Naami A,Breuer E,Zafrakas M,Bektas N,Dürst M,Kristiansen G,Wild PJ,Hartmann A,Knuechel R,Dahl E

    更新日期：2008-01-31 00:00:00

  • Mutations in the thymidine kinase gene that allow expression of the enzyme in quiescent (G0) cells.

    abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Kauffman MG,Rose PA,Kelly TJ

    更新日期：1991-08-01 00:00:00

  • Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer.

    abstract：:Inherited mutations in the BRCA1 gene confer increased susceptibility to breast and ovarian cancer. Its role in sporadic carcinogenesis is not well defined. Somatic mutations in breast cancers have not been reported and to date there are only three reports of somatic mutations in sporadic ovarian cancers. To investiga...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202847

    authors： Khoo US,Ozcelik H,Cheung AN,Chow LW,Ngan HY,Done SJ,Liang AC,Chan VW,Au GK,Ng WF,Poon CS,Leung YF,Loong F,Ip P,Chan GS,Andrulis IL,Lu J,Ho FC

    更新日期：1999-08-12 00:00:00

  • Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.

    abstract：:The structure and expression of 14-3-3 sigma(sigma) was analysed in squamous carcinomas (SCC) of the vulva and in the vulval pre-malignant lesion vulval intraepithelial neoplasia (VIN). Sequence analysis of the sigma coding region did not detect mutations in any case of SCC or VIN III and loss of heterozygosity (LOH) ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205256

    authors： Gasco M,Sullivan A,Repellin C,Brooks L,Farrell PJ,Tidy JA,Dunne B,Gusterson B,Evans DJ,Crook T

    更新日期：2002-03-14 00:00:00

  • Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.

    abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204629

    authors： David M,Ford D,Bertoglio J,Maizel AL,Pierre J

    更新日期：2001-10-11 00:00:00

  • Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.

    abstract：:Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.338

    authors： Schoeneberger H,Belz K,Schenk B,Fulda S

    更新日期：2015-07-30 00:00:00

  • P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells.

    abstract：:We have utilized c-abl antibodies and an in vitro kinase assay to identify the protein products of the c-abl gene in mouse testis. Although the testis contains high levels of a unique c-abl mRNA, along with lower amounts of two c-abl mRNAs common to somatic cells, we detected only a single polypeptide of approximately...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Ponzetto C,Wadewitz AG,Pendergast AM,Witte ON,Wolgemuth DJ

    更新日期：1989-06-01 00:00:00

  • Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.

    abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207051

    authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

    更新日期：2003-10-23 00:00:00

  • Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies.

    abstract：:Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.612

    authors： Cao Y,Marks JW,Liu Z,Cheung LH,Hittelman WN,Rosenblum MG

    更新日期：2014-01-23 00:00:00

  • The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.

    abstract：:Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients, the promyelocytic leukemia protein PML is disrupted as are the nuclear bodies it forms. Disruption of PML and PML nuclear bodies in APL is linked to a loss of gr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203201

    authors： Topcu Z,Mack DL,Hromas RA,Borden KL

    更新日期：1999-11-25 00:00:00

  • Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profiling.

    abstract：:In this age of targeted therapy, identification of molecular pathways that are deregulated in cancer will not only elucidate underlying tumorigenic mechanisms, but may also help to determine the classes of drugs that are used for treatment. In kidney cancer, a spectrum of histological subtypes exists that are characte...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1210256

    authors： Furge KA,Tan MH,Dykema K,Kort E,Stadler W,Yao X,Zhou M,Teh BT

    更新日期：2007-02-26 00:00:00

  • Rel/NF-kappa B transcription factors and I kappa B inhibitors: evolution from a unique common ancestor.

    abstract：:From the sequences of Rel/NF-kappa B and I kappa B proteins, we constructed an alignment of their Rel Homology Domain (RHD) and ankyrin repeat domain. Using this alignment, we performed tree reconstruction with both distance matrix and parsimony analysis and estimated the branching robustness using bootstrap resamplin...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201471

    authors： Huguet C,Crepieux P,Laudet V

    更新日期：1997-12-11 00:00:00

  • The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367.

    abstract：:The MYCN gene has been implicated in certain neuronal tumours, such as neuroblastomas and retinoblastomas. These tumours express high levels of mRNA and protein of MYCN as a result of amplification. MYCN encodes a short-lived nuclear phosphoprotein whose function has not yet been elucidated. This study was undertaken ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Hamann U,Wenzel A,Frank R,Schwab M

    更新日期：1991-10-01 00:00:00

  • TGF-beta1 up-regulates paxillin protein expression in malignant astrocytoma cells: requirement for a fibronectin substrate.

    abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204996

    authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

    更新日期：2001-11-29 00:00:00

  • KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the KrasG12D p53flox/flox model.

    abstract：:Krüppel-like transcription factor 10 (KLF10), also named as TIEG1, plays essential roles in mediating transforming growth factor beta (TGFβ) signaling and has been shown to function as a tumor suppressor in multiple cancer types. However, its roles in mediating cancer progression in vivo have yet to be fully character...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.155

    authors： Weng CC,Hawse JR,Subramaniam M,Chang VHS,Yu WCY,Hung WC,Chen LT,Cheng KH

    更新日期：2017-09-28 00:00:00

  • Targeting the Akt/mTOR pathway in Brca1-deficient cancers.

    abstract：:The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human m...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.603

    authors： Xiang T,Jia Y,Sherris D,Li S,Wang H,Lu D,Yang Q

    更新日期：2011-05-26 00:00:00

  • The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells.

    abstract：:Making decisions between self-renewal and differentiation is a central ability of stem cells. Elucidation of molecular networks governing this decision is therefore of prime importance. A model of choice to explore this question is represented by chicken erythroid progenitors, in which self-renewal versus differentiat...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207049

    authors： Dazy S,Damiola F,Parisey N,Beug H,Gandrillon O

    更新日期：2003-12-18 00:00:00

  • Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.

    abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207723

    authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

    更新日期：2004-07-15 00:00:00

  • Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

    abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207097

    authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

    更新日期：2003-11-06 00:00:00

  • CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

    abstract：:Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. Here we report the identification by yeast interaction trap of a CK2 interacting protein, UBC3B, which is highly homologous to the E2 ubiquitin conjugating enzyme UBC3/CDC34. UBC3B complements the yeas...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205574

    authors： Semplici F,Meggio F,Pinna LA,Oliviero S

    更新日期：2002-06-06 00:00:00

  • Stable expression of intracellular Notch suppresses v-Src-induced transformation in avian neural cells.

    abstract：:Understanding how disruption of differentiation contributes to the cancer cell phenotype is required to identify alterations essential for malignant transformation and provide experimental basis for their correction. We investigated whether primary quail neuroretina cells, transformed by a conditional v-Src mutant (QN...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210124

    authors： Mateos S,Amarir S,Laugier D,Marx M,Calothy G

    更新日期：2007-05-17 00:00:00