Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency.

abstract：:Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed. Yet, little is known about its regulation and the molecular mechanisms through ...

journal_title：Oncogene

authors： Cork SM,Kaur B,Devi NS,Cooper L,Saltz JH,Sandberg EM,Kaluz S,Van Meir EG

更新日期：2012-12-13 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell li...

journal_title：Oncogene

authors： Grassilli E,Pisano F,Cialdella A,Bonomo S,Missaglia C,Cerrito MG,Masiero L,Ianzano L,Giordano F,Cicirelli V,Narloch R,D'Amato F,Noli B,Ferri GL,Leone BE,Stanta G,Bonin S,Helin K,Giovannoni R,Lavitrano M

更新日期：2016-08-18 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...

journal_title：Oncogene

authors： McCabe NP,De S,Vasanji A,Brainard J,Byzova TV

更新日期：2007-09-13 00:00:00

abstract：:Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...

journal_title：Oncogene

authors： Cras A,Darsin-Bettinger D,Balitrand N,Cassinat B,Soulié A,Toubert ME,Delva L,Chomienne C

更新日期：2007-06-07 00:00:00

abstract：:Animal models of BCR-ABL+ leukemias have provided important new knowledge about the molecular pathophysiology of these diseases, and answered questions that are difficult or impossible to address using BCR-ABL-expressing cell lines or primary Ph+ leukemia samples from patients. The power of mouse models lies in their ...

journal_title：Oncogene

authors： Van Etten RA

更新日期：2002-12-09 00:00:00

abstract：:The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...

journal_title：Oncogene

authors： Kim M,Tezuka T,Tanaka K,Yamamoto T

更新日期：2004-03-04 00:00:00

abstract：:Metastasis is the chief cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metasta...

journal_title：Oncogene

authors： Gao X,Pang J,Li LY,Liu WP,Di JM,Sun QP,Fang YQ,Liu XP,Pu XY,He D,Li MT,Su ZL,Li BY

更新日期：2010-08-12 00:00:00

abstract：:We have isolated mouse cDNA clones encoding Tyro 3, a receptor protein-tyrosine kinase (PTK) of the mammalin central nervous system (CNS). Expression of the Tyro 3 gene is strongly up-regulated in neurons of the mouse neocortex, cerebellum, and hippocampus after the day of birth, during periods of active synaptogenesi...

journal_title：Oncogene

authors： Lai C,Gore M,Lemke G

更新日期：1994-09-01 00:00:00

abstract：:Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies th...

journal_title：Oncogene

authors： Lockshin RA,Zakeri Z

更新日期：2004-04-12 00:00:00

abstract：:The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins. To g...

journal_title：Oncogene

authors： Zvara A,Fajardo JE,Escalante M,Cotton G,Muir T,Kirsch KH,Birge RB

更新日期：2001-02-22 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molecular aberrations of...

journal_title：Oncogene

authors： Calabretta S,Bielli P,Passacantilli I,Pilozzi E,Fendrich V,Capurso G,Fave GD,Sette C

更新日期：2016-04-21 00:00:00

abstract：:Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interaction...

journal_title：Oncogene

authors： Li Z,Jiao X,Di Sante G,Ertel A,Casimiro MC,Wang M,Katiyar S,Ju X,Klopfenstein DV,Tozeren A,Dampier W,Chepelev I,Jeltsch A,Pestell RG

更新日期：2019-05-01 00:00:00

abstract：:A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains to be elucidated. I...

journal_title：Oncogene

authors： Yao R,Natsume Y,Noda T

更新日期：2004-08-12 00:00:00

abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

journal_title：Oncogene

authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

更新日期：2003-07-10 00:00:00

abstract：:Members of the ErbB family of receptors have been implicated in regulation of androgen receptor (AR) activity. Ebp1, an ErbB-3 binding protein recently cloned in our laboratory, possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors. Therefore, we sought to determine if Ebp1 could ...

journal_title：Oncogene

authors： Zhang Y,Fondell JD,Wang Q,Xia X,Cheng A,Lu ML,Hamburger AW

更新日期：2002-08-15 00:00:00

abstract：:Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...

journal_title：Oncogene

authors： Zhou W,Sun W,Yung MMH,Dai S,Cai Y,Chen CW,Meng Y,Lee JB,Braisted JC,Xu Y,Southall NT,Shinn P,Huang X,Song Z,Chen X,Kai Y,Cai X,Li Z,Hao Q,Cheung ANY,Ngan HYS,Liu SS,Barak S,Hao J,Dai Z,Tzatsos A,Peng W

更新日期：2018-07-01 00:00:00

abstract：:Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of beta-catenin. We here demonstrate that a functional crosstalk between Met and beta-...

journal_title：Oncogene

authors： Rasola A,Fassetta M,De Bacco F,D'Alessandro L,Gramaglia D,Di Renzo MF,Comoglio PM

更新日期：2007-02-15 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:The E6 proteins of specific cancer-associated human papillomaviruses (HPVs) complex with and mediate degradation of the cellular anti-oncogene p53 in vitro. A critical property of p53 is its ability to stimulate transcription from promoters containing its recognition sequence. HPV E6, mutant p53 proteins, and several ...

journal_title：Oncogene

authors： Mansur CP,Marcus B,Dalal S,Androphy EJ

更新日期：1995-02-02 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newly established from human oral cancer patients. ZA had a point mutational activation at the 13th codon, this activation of c-...

journal_title：Oncogene

authors： Tadokoro K,Ueda M,Ohshima T,Fujita K,Rikimaru K,Takahashi N,Enomoto S,Tsuchida N

更新日期：1989-04-01 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human m...

journal_title：Oncogene

authors： Xiang T,Jia Y,Sherris D,Li S,Wang H,Lu D,Yang Q

更新日期：2011-05-26 00:00:00

abstract：:Treatment of many cancers relies on the combined action of several genotoxins, but the detrimental effect of these drugs on normal cells can cause severe side effects. One major challenge in anticancer therapy is therefore to increase the selectivity of current treatments toward cancer cells in order to spare normal c...

journal_title：Oncogene

authors： Michod D,Yang JY,Chen J,Bonny C,Widmann C

更新日期：2004-11-25 00:00:00

abstract：:To investigate a possible role for c-Jun homodimers in c-Jun-mediated transformation, we designed two chimeric c-Jun derivatives, called c-Juneb1 and c-Jungcn4. In these chimeric derivatives the natural dimerization domain of c-Jun was replaced by the heterologous homodimerization domain of the Epstein-Barr virus EB1 ...

journal_title：Oncogene

authors： Castellazzi M,Loiseau L,Piu F,Sergeant A

更新日期：1993-05-01 00:00:00

abstract：:Activation of hypoxia-inducible factor (HIF) is due to loss of von Hippel-Lindau protein (pVHL) function in most clear cell renal cell carcinomas (ccRCCs). Here we describe a novel pVHL-independent mechanism of HIF regulation and identify nuclear factor (NF)-κB essential modulator (NEMO) as a hitherto unknown oncogeni...

journal_title：Oncogene

authors： Nowicka AM,Häuselmann I,Borsig L,Bolduan S,Schindler M,Schraml P,Heikenwalder M,Moch H

更新日期：2016-06-16 00:00:00

abstract：:Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially sst2, their role and therapeutic potential remain uncertain. Recently, we identified a new truncated s...

journal_title：Oncogene

authors： Durán-Prado M,Gahete MD,Hergueta-Redondo M,Martínez-Fuentes AJ,Córdoba-Chacón J,Palacios J,Gracia-Navarro F,Moreno-Bueno G,Malagón MM,Luque RM,Castaño JP

更新日期：2012-04-19 00:00:00

abstract：:c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...

journal_title：Oncogene

authors： Dorey K,Engen JR,Kretzschmar J,Wilm M,Neubauer G,Schindler T,Superti-Furga G

更新日期：2001-12-06 00:00:00