Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor.

abstract：:Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vit...

journal_title：Oncogene

authors： Gu G,Tian L,Herzog SK,Rechoum Y,Gelsomino L,Gao M,Du L,Kim JA,Dustin D,Lo HC,Beyer AR,Edwards DG,Gonzalez T,Tsimelzon A,Huang HJ,Fernandez NM,Grimm SL,Hilsenbeck SG,Liu D,Xu J,Alaniz A,Li S,Mills GB,Janku F

更新日期：2020-12-15 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human...

journal_title：Oncogene

authors： Schmidt AK,Pudelko K,Boekenkamp JE,Berger K,Kschischo M,Bastians H

更新日期：2021-01-01 00:00:00

abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...

journal_title：Oncogene

authors： Oricchio E,Sciamanna I,Beraldi R,Tolstonog GV,Schumann GG,Spadafora C

更新日期：2007-06-21 00:00:00

abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...

journal_title：Oncogene

authors： Kato Y,Sasagawa I,Kaneko M,Osawa M,Fujita N,Tsuruo T

更新日期：2004-11-04 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, possesses significant anti-inflammatory and cancer chemopreventive properties. Studies have shown the photochemopreventive effects of green tea and EGCG in cell culture, animal models, and human skin. The molecular mechanism(s) of photochemoprevent...

journal_title：Oncogene

authors： Afaq F,Adhami VM,Ahmad N,Mukhtar H

更新日期：2003-02-20 00:00:00

abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

journal_title：Oncogene

authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

更新日期：2000-09-07 00:00:00

abstract：:To gain better understanding of the molecular alterations responsible for the aggressive growth potential of epidermal growth factor receptor (EGFR)-positive breast cancers, we utilized an expression cloning strategy to seek gene products that mediate the EGF-independent growth of human breast cancer cells. A retrovir...

journal_title：Oncogene

authors： Berquin IM,Dziubinski ML,Nolan GP,Ethier SP

更新日期：2001-07-05 00:00:00

abstract：:The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...

journal_title：Oncogene

authors： Rolley N,Butcher S,Milner J

更新日期：1995-08-17 00:00:00

abstract：:eIF4E is essential for translation initiation, but its overexpression causes malignant transformation. Recent work demonstrated that eIF4E/F participates in exposing and locating alternate translation start codons during scanning. Translation initiation of several important protooncogenes and growth-regulators, such a...

journal_title：Oncogene

authors： Carter PS,Jarquin-Pardo M,De Benedetti A

更新日期：1999-07-29 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most abundantly expressed variant that drives p...

journal_title：Oncogene

authors： Liu LL,Xie N,Sun S,Plymate S,Mostaghel E,Dong X

更新日期：2014-06-12 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:The RNA-binding protein (RBP) RNPC1 is a target of the p53 family and forms a feedback regulatory loop with the p53 family proteins. The murine double minute-2 (MDM2) oncogene, a key negative regulator of p53, has a critical role in a variety of fundamental cellular processes. MDM2 expression is found to be regulated ...

journal_title：Oncogene

authors： Xu E,Zhang J,Chen X

更新日期：2013-04-25 00:00:00

abstract：:Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear. Here, we show that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with tumor node metastasis stage (III or IV) or lymph node metastasis. MiR-25 inhibition si...

journal_title：Oncogene

authors： Li BS,Zuo QF,Zhao YL,Xiao B,Zhuang Y,Mao XH,Wu C,Yang SM,Zeng H,Zou QM,Guo G

更新日期：2015-05-14 00:00:00

abstract：:The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported to exhibit anticancer properties. However, the mechanisms by which silibinin inhibits tumour growth are not f...

journal_title：Oncogene

authors： García-Maceira P,Mateo J

更新日期：2009-01-22 00:00:00

abstract：:Overexpression of the nuclear phosphoprotein p53 has been detected in many different transformed human cell lines and primary adult tumors. Elevated steady-state levels of p53 appear to be the result of an increase in the stability of the protein and, in adult cancers, high levels of the protein are associated with mu...

journal_title：Oncogene

authors： Davidoff AM,Pence JC,Shorter NA,Iglehart JD,Marks JR

更新日期：1992-01-01 00:00:00

abstract：:Recent studies suggest that medulloblastoma, the most common malignant brain tumor of childhood, is comprised of four disease variants. The WIP1 oncogene is overexpressed in Group 3 and 4 tumors, which contain medulloblastomas with the most aggressive clinical behavior. Our data demonstrate increased WIP1 expression i...

journal_title：Oncogene

authors： Buss MC,Remke M,Lee J,Gandhi K,Schniederjan MJ,Kool M,Northcott PA,Pfister SM,Taylor MD,Castellino RC

更新日期：2015-02-26 00:00:00

abstract：:DNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and recent research implicates alterations in chromatin structure as the mechanistic basis for this repressi...

journal_title：Oncogene

authors： Karpf AR,Jones DA

更新日期：2002-08-12 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00

abstract：:The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biolo...

journal_title：Oncogene

authors： Yao R,Kondoh Y,Natsume Y,Yamanaka H,Inoue M,Toki H,Takagi R,Shimizu T,Yamori T,Osada H,Noda T

更新日期：2014-08-14 00:00:00

abstract：:Rad51 protein plays a pivotal role in homologous recombination (HR), which is involved in double-strand break repair and in genome maintenance. Despite interactions with tumor suppressor proteins, the role of mammalian Rad51 and more generally of HR in tumor prevention is not clearly established. Indeed, both high and...

journal_title：Oncogene

authors： Bertrand P,Lambert S,Joubert C,Lopez BS

更新日期：2003-10-23 00:00:00

abstract：:Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...

journal_title：Oncogene

authors： Mendelsohn J,Baselga J

更新日期：2000-12-27 00:00:00

abstract：:BRAF mutations occur in ~10% of colorectal cancer (CRC) and are associated with poor prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF mutant, elicit only poor response rates in BRAF-mutant CRC as single agents. This unresponsiveness was mechanistically attributed to the loss of negat...

journal_title：Oncogene

authors： Herr R,Halbach S,Heizmann M,Busch H,Boerries M,Brummer T

更新日期：2018-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcripti...

journal_title：Oncogene

authors： Liu Y,Zhou H,Zhu R,Ding F,Li Y,Cao X,Liu Z

更新日期：2018-02-08 00:00:00

abstract：:A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

journal_title：Oncogene

authors： Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

更新日期：1994-06-01 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...

journal_title：Oncogene

authors： McCullough ML,Giovannucci EL

更新日期：2004-08-23 00:00:00

abstract：:Germline mutations of the RET proto-oncogene are responsible for the familial tumor syndrome called multiple endocrine neoplasia type 2 (MEN 2) that includes medullary thyroid carcinoma (MTC). Although inherited mutations of RET lead to tumor formation in patients with MEN 2, it is not understood why only selected cel...

journal_title：Oncogene

authors： Koch CA,Huang SC,Moley JF,Azumi N,Chrousos GP,Gagel RF,Zhuang Z,Pacak K,Vortmeyer AO

更新日期：2001-11-22 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00