The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants.

abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

journal_title：Oncogene

authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

更新日期：2009-02-26 00:00:00

abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

journal_title：Oncogene

authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

更新日期：1992-08-01 00:00:00

abstract：:Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) ana...

journal_title：Oncogene

authors： Mori M,Barnard GF,Staniunas RJ,Jessup JM,Steele GD Jr,Chen LB

更新日期：1993-10-01 00:00:00

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...

journal_title：Oncogene

authors： Nakagawachi T,Soejima H,Urano T,Zhao W,Higashimoto K,Satoh Y,Matsukura S,Kudo S,Kitajima Y,Harada H,Furukawa K,Matsuzaki H,Emi M,Nakabeppu Y,Miyazaki K,Sekiguchi M,Mukai T

更新日期：2003-12-04 00:00:00

abstract：:Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor suppressor genes. Much of our understanding of tumor suppressor gene function is derived from experimental manipulations in cultured cells. Recently, however, the generation of mice with germ line tumor suppressor gene mutations...

journal_title：Oncogene

authors： Ghebranious N,Donehower LA

更新日期：1998-12-24 00:00:00

abstract：:Soft tissue sarcomas are a heterogeneous group of neoplasms with various histological subtypes. Up to now, no individual causal molecular markers for prognosis and therapeutic success have been identified. A tumorigenic connection between the oncogene product Mdm2 and tumor suppressor p53 is generally accepted, but th...

journal_title：Oncogene

authors： Würl P,Meye A,Schmidt H,Lautenschläger C,Kalthoff H,Rath FW,Taubert H

更新日期：1998-03-05 00:00:00

abstract：:The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of v...

journal_title：Oncogene

authors： Stebbing J,Lit LC,Zhang H,Darrington RS,Melaiu O,Rudraraju B,Giamas G

更新日期：2014-02-20 00:00:00

abstract：:Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated that nuclear ErbB-2 (NErbB-2) also plays a key role in BC and is a poor prognostic factor in ErbB...

journal_title：Oncogene

authors： Venturutti L,Romero LV,Urtreger AJ,Chervo MF,Cordo Russo RI,Mercogliano MF,Inurrigarro G,Pereyra MG,Proietti CJ,Izzo F,Díaz Flaqué MC,Sundblad V,Roa JC,Guzmán P,Bal de Kier Joffé ED,Charreau EH,Schillaci R,Elizalde PV

更新日期：2016-04-28 00:00:00

abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...

journal_title：Oncogene

authors： Urano T,Furukawa K,Shiku H

更新日期：1993-05-01 00:00:00

abstract：:The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. T...

journal_title：Oncogene

authors： Robinson JP,Vanbrocklin MW,Lastwika KJ,McKinney AJ,Brandner S,Holmen SL

更新日期：2011-03-17 00:00:00

abstract：:MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...

journal_title：Oncogene

authors： Widmann C,Johnson NL,Gardner AM,Smith RJ,Johnson GL

更新日期：1997-11-13 00:00:00

abstract：:The c-Myb, A-Myb and B-Myb transcription factors have nearly identical DNA-binding domains, activate the same reporter gene constructs in animal cells, but have different biological roles. The Myb proteins are often coexpressed in the same cells, raising questions about whether they activate similar or distinct gene e...

journal_title：Oncogene

authors： Rushton JJ,Davis LM,Lei W,Mo X,Leutz A,Ness SA

更新日期：2003-01-16 00:00:00

abstract：:The vast majority of cancer cells have defective checkpoints that permit the cell cycle to progress in the presence of double-strand DNA breaks (DSBs) caused by ionizing radiation (IR) and radiomimetic drugs. ATR (ataxia telangiectasia-mutated and Rad3-related) has recently been shown to be activated by DSBs, although...

journal_title：Oncogene

authors： Hurley PJ,Wilsker D,Bunz F

更新日期：2007-04-19 00:00:00

abstract：:Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...

journal_title：Oncogene

authors： McIlroy D,Sakahira H,Talanian RV,Nagata S

更新日期：1999-08-05 00:00:00

abstract：:While screening a chicken kidney cDNA library for the normal homolog of the yes oncogene, we isolated a clone that encodes a novel non-receptor type protein tyrosine kinase of the Src family. We named this gene product Yrk (York), as an acronym for Yes-related kinase. As predicted from the cDNA sequence, the Yrk prote...

journal_title：Oncogene

authors： Sudol M,Greulich H,Newman L,Sarkar A,Sukegawa J,Yamamoto T

更新日期：1993-04-01 00:00:00

abstract：:Previous reports have indicated that the cellular slime mold Dictyostelium discoideum possesses two ras genes (rasG and rasD) and one rap gene (rap1). All three genes are developmentally regulated, with each showing a different pattern of transcription during the Dictyostelium life cycle. To establish whether there ar...

journal_title：Oncogene

authors： Daniel J,Spiegelman GB,Weeks G

更新日期：1993-04-01 00:00:00

abstract：:E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...

journal_title：Oncogene

authors： Teodoro JG,Shore GC,Branton PE

更新日期：1995-08-03 00:00:00

abstract：:Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...

journal_title：Oncogene

authors： McCormick F

更新日期：2005-11-21 00:00:00

abstract：:Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteob...

journal_title：Oncogene

authors： Cook LM,Frieling JS,Nerlakanti N,McGuire JJ,Stewart PA,Burger KL,Cleveland JL,Lynch CC

更新日期：2019-10-01 00:00:00

abstract：:Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably...

journal_title：Oncogene

authors： Amar D,Izraeli S,Shamir R

更新日期：2017-06-15 00:00:00

abstract：:As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...

journal_title：Oncogene

authors： Mishra L,Tully RE,Monga SP,Yu P,Cai T,Makalowski W,Mezey E,Pavan WJ,Mishra B

更新日期：1997-11-06 00:00:00

abstract：:We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene...

journal_title：Oncogene

authors： Voz ML,Aström AK,Kas K,Mark J,Stenman G,Van de Ven WJ

更新日期：1998-03-01 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:Radicicol, an inhibitor of Src-family protein-tyrosine kinases, causes morphological reversion of v-src- and v-Ha-ras-transformed fibroblasts and arrest of the cell cycle at both the G1 and the G2 phases. Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cel...

journal_title：Oncogene

authors： Kwon HJ,Yoshida M,Nagaoka R,Obinata T,Beppu T,Horinouchi S

更新日期：1997-11-20 00:00:00

abstract：:The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...

journal_title：Oncogene

authors： Li Y,Clevenger CV,Minkovsky N,Kumar KG,Raghunath PN,Tomaszewski JE,Spiegelman VS,Fuchs SY

更新日期：2006-03-23 00:00:00

abstract：:Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing t...

journal_title：Oncogene

authors： Gu P,Wang Y,Bisht KK,Wu L,Kukova L,Smith EM,Xiao Y,Bailey SM,Lei M,Nandakumar J,Chang S

更新日期：2017-04-06 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:Tek/Tie2 is an endothelial cell-specific receptor tyrosine kinase that has been shown to play a role in vascular development of the mouse. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathway(s) mediated by this rec...

journal_title：Oncogene

authors： Jones N,Dumont DJ

更新日期：1998-09-03 00:00:00

abstract：:Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...

journal_title：Oncogene

authors： Lord KA,Hoffman-Liebermann B,Liebermann DA

更新日期：1990-03-01 00:00:00