HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells.

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown to be important in the regulation of proliferation and apoptosis. In this report, we investigated the role of the PKC-like kinase PKCmu in the control of these...

journal_title：Oncogene

authors： Trauzold A,Schmiedel S,Sipos B,Wermann H,Westphal S,Röder C,Klapper W,Arlt A,Lehnert L,Ungefroren H,Johannes FJ,Kalthoff H

更新日期：2003-12-04 00:00:00

abstract：:Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cel...

journal_title：Oncogene

authors： Yatabe Y,Mitsudomi T,Takahashi T

更新日期：2004-05-20 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...

journal_title：Oncogene

authors： Braig S,Bosserhoff AK

更新日期：2013-02-14 00:00:00

abstract：:To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...

journal_title：Oncogene

authors： St-Onge L,Bastin M

更新日期：1994-03-01 00:00:00

abstract：:Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...

journal_title：Oncogene

authors： Patzke S,Hauge H,Sioud M,Finne EF,Sivertsen EA,Delabie J,Stokke T,Aasheim HC

更新日期：2005-02-10 00:00:00

abstract：:c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II,...

journal_title：Oncogene

authors： Kanazawa S,Soucek L,Evan G,Okamoto T,Peterlin BM

更新日期：2003-08-28 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...

journal_title：Oncogene

authors： Kim EK,Yun SJ,Ha JM,Kim YW,Jin IH,Yun J,Shin HK,Song SH,Kim JH,Lee JS,Kim CD,Bae SS

更新日期：2011-06-30 00:00:00

abstract：:Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...

journal_title：Oncogene

authors： Xu L,Chen S,Bergan RC

更新日期：2006-05-18 00:00:00

abstract：:rho genes have been found in both lower and higher eucaryotes. They code for proteins of 21 kDa, highly conserved in evolution, which belong to the superfamily of ras GTPases. Among the members of this superfamily there are proteins with a regulatory function, such as ras, and proteins involved in vesicular traffickin...

journal_title：Oncogene

authors： Perona R,Esteve P,Jiménez B,Ballestero RP,Ramón y Cajal S,Lacal JC

更新日期：1993-05-01 00:00:00

abstract：:The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activa...

journal_title：Oncogene

authors： Edwards LA,Thiessen B,Dragowska WH,Daynard T,Bally MB,Dedhar S

更新日期：2005-05-19 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

journal_title：Oncogene

authors： Kuang C,Chen Y

更新日期：2004-02-05 00:00:00

abstract：:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...

journal_title：Oncogene

authors： Teshima K,Nara M,Watanabe A,Ito M,Ikeda S,Hatano Y,Oshima K,Seto M,Sawada K,Tagawa H

更新日期：2014-04-24 00:00:00

abstract：:Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven dist...

journal_title：Oncogene

authors： Dhanasekaran N,Premkumar Reddy E

更新日期：1998-09-17 00:00:00

abstract：:The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...

journal_title：Oncogene

authors： Roth M,Chen WY

更新日期：2014-03-27 00:00:00

abstract：:Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as beta-catenin) endowed with both adhesion a...

journal_title：Oncogene

authors： Chiarugi P,Taddei ML,Schiavone N,Papucci L,Giannoni E,Fiaschi T,Capaccioli S,Raugei G,Ramponi G

更新日期：2004-05-13 00:00:00

abstract：:Drosophila tumor suppressor WARTS (Wts) is an evolutionally conserved serine / threonine kinase and participates in a signaling complex that regulates both proliferation and apoptosis to ensure the proper size and shape of the fly. Human counterparts of this complex have been found to be frequently downregulated or mu...

journal_title：Oncogene

authors： Kuninaka S,Nomura M,Hirota T,Iida S,Hara T,Honda S,Kunitoku N,Sasayama T,Arima Y,Marumoto T,Koja K,Yonehara S,Saya H

更新日期：2005-08-11 00:00:00

abstract：:Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member of the Sin3 family of proteins linked to tumorigenesis that are thought to regulate gene expression through their role as histone deacetylas...

journal_title：Oncogene

authors： Das TK,Sangodkar J,Negre N,Narla G,Cagan RL

更新日期：2013-06-27 00:00:00

abstract：:Cytokine receptors have different signaling requirements which ultimately lead to various physiological responses. In an effort to precisely characterize the molecular determinants involved in the proliferative response mediated by cytokines, we examine dose-dependent proliferation of the betac (GM-CSF, IL-3, IL-5) an...

journal_title：Oncogene

authors： Piu F,Magnani M,Ader ME

更新日期：2002-05-16 00:00:00

abstract：:ErbB-2 is an orphan receptor that belongs to a family of tyrosine kinase receptors for either epidermal growth factor (EGF) or Neu differentiation factor (NDF/neuregulin). Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, t...

journal_title：Oncogene

authors： Klapper LN,Vaisman N,Hurwitz E,Pinkas-Kramarski R,Yarden Y,Sela M

更新日期：1997-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related long non-coding RNAs (lncRNAs) to understand the molecular mechanism of HCC metastasis. We first identified that miR-1258 was downregulated in HCC tissues both in The Ca...

journal_title：Oncogene

authors： Huang WJ,Tian XP,Bi SX,Zhang SR,He TS,Song LY,Yun JP,Zhou ZG,Yu RM,Li M

更新日期：2020-06-01 00:00:00

abstract：:Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...

journal_title：Oncogene

authors： Maurici D,Monti P,Campomenosi P,North S,Frebourg T,Fronza G,Hainaut P

更新日期：2001-06-14 00:00:00

abstract：:To gain a more complete understanding of c-myc regulation in chickens, we have completed the structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcription and protein expression. A comparison of c-myc structure and expression between mammals and birds presents an enigma: there...

journal_title：Oncogene

authors： Petropoulos CJ,Givol I,Hughes SH

更新日期：1996-06-20 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:The c-myc oncogene is the most extensively studied member of the myc gene family which now consists of three characterized members, namely the c-myc, N-myc and L-myc genes. These genes are often found amplified in cell lines from small cell carcinomas of the lung (SCLC). In this study the L-myc gene was examined in a ...

journal_title：Oncogene

authors： Saksela K

更新日期：1987-01-01 00:00:00

abstract：:We isolated three related cDNA clones from a mouse cerebellar library; the type I cDNA was identical to the gene encoding the apoptosis-associated tyrosine kinase (AATYK), whose expression in myeloid precursor cells is increased during growth arrest or apoptosis. Low levels of AATYK mRNA expression were seen in adult ...

journal_title：Oncogene

authors： Tomomura M,Fernandez-Gonzales A,Yano R,Yuzaki M

更新日期：2001-03-01 00:00:00

abstract：:Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis ...

journal_title：Oncogene

authors： Wang M,Nagle RB,Knudsen BS,Cress AE,Rogers GC

更新日期：2020-01-01 00:00:00

abstract：:To ensure that their mRNAs are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. In many cases, the ability to productively engage host translational comp...

journal_title：Oncogene

authors： Mohr I

更新日期：2005-11-21 00:00:00