Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS.

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00

abstract：:Germline mutations of the RET proto-oncogene are responsible for the familial tumor syndrome called multiple endocrine neoplasia type 2 (MEN 2) that includes medullary thyroid carcinoma (MTC). Although inherited mutations of RET lead to tumor formation in patients with MEN 2, it is not understood why only selected cel...

journal_title：Oncogene

authors： Koch CA,Huang SC,Moley JF,Azumi N,Chrousos GP,Gagel RF,Zhuang Z,Pacak K,Vortmeyer AO

更新日期：2001-11-22 00:00:00

abstract：:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...

journal_title：Oncogene

authors： Givol I,Givol D,Hughes SH

更新日期：1998-06-18 00:00:00

abstract：:Telomerase is a ribonucleoprotein whose activity has been detected in germline cells and in neoplastic and immortal cells. Telomerase compensates the telomere loss arising by the end replication problem by synthesizing telomeric repeats at the 3' end of the eukaryotic chromosomes. Telomerase is reactivated during canc...

journal_title：Oncogene

authors： Hande MP,Balajee AS,Natarajan AT

更新日期：1997-10-02 00:00:00

abstract：:Snail1 is a master regulator of the epithelial-mesenchymal transition (EMT) and has been implicated in key tumor biological processes such as invasion and metastasis. It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1. In ...

journal_title：Oncogene

authors： Rodríguez MI,González-Flores A,Dantzer F,Collard J,de Herreros AG,Oliver FJ

更新日期：2011-10-20 00:00:00

abstract：:Assessment of the genetic instability of a microsatellite has indicated a new mechanism in human carcinogenesis. Examination was made to determine whether microsatellite instability is associated with the onset of prostate cancer. Twenty-nine DNA samples from 24 primary prostate cancer, two metastatic lymph-node and t...

journal_title：Oncogene

authors： Uchida T,Wada C,Wang C,Ishida H,Egawa S,Yokoyama E,Ohtani H,Koshiba K

更新日期：1995-03-02 00:00:00

abstract：:Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppr...

journal_title：Oncogene

authors： Wang J,Ding S,Duan Z,Xie Q,Zhang T,Zhang X,Wang Y,Chen X,Zhuang H,Lu F

更新日期：2016-03-31 00:00:00

abstract：:Upregulation and activation of epidermal growth factor receptor and/or urokinase-type plasminogen activator receptor in a variety of cancers have been shown to be associated with poor prognosis. High-molecular-weight kininogen can be hydrolysed by plasma kallikrein to bradykinin and cleaved high-molecular-weight kinin...

journal_title：Oncogene

authors： Liu Y,Pixley R,Fusaro M,Godoy G,Kim E,Bromberg ME,Colman RW

更新日期：2009-07-30 00:00:00

abstract：:We have identified sequences in the 5' flanking region of the murine c-myc gene's P1 and P2 transcription initiation sites which form specific complexes with nuclear factors of murine and human origin and are also required for normal P1 and P2 usage. Four nuclear factor binding sites were identified within 400 bp 5' o...

journal_title：Oncogene

authors： Asselin C,Nepveu A,Marcu KB

更新日期：1989-05-01 00:00:00

abstract：:E mu-bcl-2 transgenic mice bearing the bcl-2 proto-oncogene linked to the immunoglobulin enhancer (E mu) sporadically develop B or T cell lymphomas after a long latent period. To identify genes that play important roles in development of lymphoid malignancies, proviral insertional mutagenesis with Moloney murine leuke...

journal_title：Oncogene

authors： Shinto Y,Morimoto M,Katsumata M,Uchida A,Aozasa K,Okamoto M,Kurosawa T,Ochi T,Greene MI,Tsujimoto Y

更新日期：1995-11-02 00:00:00

abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...

journal_title：Oncogene

authors： Galland F,Pirisi V,de Lapeyriere O,Birnbaum D

更新日期：1991-05-01 00:00:00

abstract：:Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-bin...

journal_title：Oncogene

authors： Suraweera N,Meijne E,Moody J,Carvajal-Carmona LG,Yoshida K,Pollard P,Fitzgibbon J,Riches A,van Laar T,Huiskamp R,Rowan A,Tomlinson IP,Silver A

更新日期：2005-05-19 00:00:00

abstract：:I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also d...

journal_title：Oncogene

authors： Yoshida M

更新日期：2005-09-05 00:00:00

abstract：:Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown to be important in the regulation of proliferation and apoptosis. In this report, we investigated the role of the PKC-like kinase PKCmu in the control of these...

journal_title：Oncogene

authors： Trauzold A,Schmiedel S,Sipos B,Wermann H,Westphal S,Röder C,Klapper W,Arlt A,Lehnert L,Ungefroren H,Johannes FJ,Kalthoff H

更新日期：2003-12-04 00:00:00

abstract：:The overexpression or mutation of tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR), can lead to the development of cancer. The most common mutation of the EGFR in glioblastomas is the deletion of exons 2-7 known as the EGFRvIII. This mutant receptor cannot bind EGF but, instead, is constitut...

journal_title：Oncogene

authors： Davies GC,Ryan PE,Rahman L,Zajac-Kaye M,Lipkowitz S

更新日期：2006-10-19 00:00:00

abstract：:Although p73alpha induces many of the same cellular events as p53, it is structurally distinct from p53 in that it possesses a unique COOH-terminal domain. To dissect the function of this domain, we performed yeast two-hybrid screening of a HeLa cDNA library using residues 552-636 of p73alpha as bait. Among the clones...

journal_title：Oncogene

authors： Lee YG,Lee SW,Sin HS,Kim EJ,Um SJ

更新日期：2009-02-19 00:00:00

abstract：:We previously showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages. To elucidate the biological role of MSP we studied the expression of the Ron receptor in vivo, and the response to the ...

journal_title：Oncogene

authors： Gaudino G,Avantaggiato V,Follenzi A,Acampora D,Simeone A,Comoglio PM

更新日期：1995-12-21 00:00:00

abstract：:Induction of apoptosis in tumor cells is an important mechanism of chemotherapy-induced cell death. The tumor-suppressor gene p53 is required for the efficient activation of apoptosis following chemotherapy. However, the molecular mechanism regulating p53-associated apoptosis remains controversial. In this study, we s...

journal_title：Oncogene

authors： Kondo S,Barnett GH,Hara H,Morimura T,Takeuchi J

更新日期：1995-05-18 00:00:00

abstract：:Aberrant protein glycosylation could be a distinct surface-marker of cancer cells that influences cancer progression and metastasis because glycosylation can regulate membrane protein folding which alters receptor activation and changes epitope exposure for antibody (Ab) recognition. Carcinoembryonic antigen-related c...

journal_title：Oncogene

authors： Chiang WF,Cheng TM,Chang CC,Pan SH,Changou CA,Chang TH,Lee KH,Wu SY,Chen YF,Chuang KH,Shieh DB,Chen YL,Tu CC,Tsui WL,Wu MH

更新日期：2018-01-04 00:00:00

abstract：:The co-chaperone protein, BAG3, which belongs to the BAG protein family, has an established antiapoptotic function in different tumor cell lines. Here we demonstrated that treatment of the human neuroblastoma cell line, SK-N-MC, with fibroblast growth factor-2 (FGF-2) results in induction of BAG3 expression. Induction...

journal_title：Oncogene

authors： Gentilella A,Passiatore G,Deshmane S,Turco MC,Khalili K

更新日期：2008-08-28 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...

journal_title：Oncogene

authors： Sastry KJ,Marin MC,Nehete PN,McConnell K,el-Naggar AK,McDonnell TJ

更新日期：1996-08-01 00:00:00

abstract：:The RAS-RAF-MEK-ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF and MEK inhibitors are available that provide survival benefits...

journal_title：Oncogene

authors： Dankner M,Rose AAN,Rajkumar S,Siegel PM,Watson IR

更新日期：2018-06-01 00:00:00

abstract：:The microtubule-targeting antineoplastic agent, paclitaxel, is highly efficacious against a wide spectrum of human cancers. However, dose-limiting toxicity and development of drug resistance limit its clinical application. Development of novel strategies that overcome chemoresistance and sensitize cancer cells to pacl...

journal_title：Oncogene

authors： Sreekanth CN,Bava SV,Sreekumar E,Anto RJ

更新日期：2011-07-14 00:00:00

abstract：:Mammalian heparanase (endo-beta-glucuronidase) degrades heparan sulfate proteoglycans and is an important modulator of the extracellular matrix and associated factors. The enzyme is preferentially expressed in neoplastic tissues and contributes to tumour metastasis and angiogenesis. To investigate the epigenetic regul...

journal_title：Oncogene

authors： Shteper PJ,Zcharia E,Ashhab Y,Peretz T,Vlodavsky I,Ben-Yehuda D

更新日期：2003-10-30 00:00:00

abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...

journal_title：Oncogene

authors： Ying M,Zhang L,Zhou Q,Shao X,Cao J,Zhang N,Li W,Zhu H,Yang B,He Q

更新日期：2016-08-18 00:00:00

abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...

journal_title：Oncogene

authors： Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

更新日期：2019-04-01 00:00:00

abstract：:Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To define the nature of the interaction between rhuMAb HER2 and other classes of cytotoxic drugs, we applied multiple drug effect/combination index (CI) isobologra...

journal_title：Oncogene

authors： Pegram M,Hsu S,Lewis G,Pietras R,Beryt M,Sliwkowski M,Coombs D,Baly D,Kabbinavar F,Slamon D

更新日期：1999-04-01 00:00:00

abstract：:We have cloned and sequenced a Xenopus p53 homologue which differs by one amino acid deletion from a previously published Xenopus sequence (Soussi et al., 1987). Transcription analysis revealed that this gene is activated during early oogenesis and that zygotic transcription initiates after midblastula transition. Tra...

journal_title：Oncogene

authors： Hoever M,Clement JH,Wedlich D,Montenarh M,Knöchel W

更新日期：1994-01-01 00:00:00

abstract：:Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic predictor of shorter survival of breast cancer pat...

journal_title：Oncogene

authors： Roy SS,Gonugunta VK,Bandyopadhyay A,Rao MK,Goodall GJ,Sun LZ,Tekmal RR,Vadlamudi RK

更新日期：2014-07-10 00:00:00

abstract：:Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...

journal_title：Oncogene

authors： Schulte JH,Schramm A,Klein-Hitpass L,Klenk M,Wessels H,Hauffa BP,Eils J,Eils R,Brodeur GM,Schweigerer L,Havers W,Eggert A

更新日期：2005-01-06 00:00:00