MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.

abstract：:Heterozygous germline mutations in PHOX2B, a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the sympathetic nervous system, including neuroblastoma and congenital central hypoventilation syndrome (CCHS). Although the PHOX2B variants in CCHS largely involve expansions of th...

journal_title：Oncogene

authors： Wang W,Zhong Q,Teng L,Bhatnagar N,Sharma B,Zhang X,Luther W 2nd,Haynes LP,Burgoyne RD,Vidal M,Volchenboum S,Hill DE,George RE

更新日期：2014-06-19 00:00:00

abstract：:An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...

journal_title：Oncogene

authors： Prévostel C,Alvaro V,de Boisvilliers F,Martin A,Jaffiol C,Joubert D

更新日期：1995-08-17 00:00:00

abstract：:Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multistage disease characterized by an early proliferative stage driven by the interaction of the viral glycoprotein, gp55, with Sf-Stk and the EpoR, a...

journal_title：Oncogene

authors： Hegde S,Ni S,He S,Yoon D,Feng GS,Watowich SS,Paulson RF,Hankey PA

更新日期：2009-09-24 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...

journal_title：Oncogene

authors： Queisser A,Hagedorn S,Wang H,Schaefer T,Konantz M,Alavi S,Deng M,Vogel W,von Mässenhausen A,Kristiansen G,Duensing S,Kirfel J,Lengerke C,Perner S

更新日期：2017-03-01 00:00:00

abstract：:Many reports have shown a link between mismatch repair (MMR) deficiency and loss of normal cell cycle control, particularly loss of G2 arrest. However almost all of these studies utilized transformed cell lines, and thus the involvement of other genes in this phenotype cannot be excluded. We have examined the effects ...

journal_title：Oncogene

authors： Strathdee G,Sansom OJ,Sim A,Clarke AR,Brown R

更新日期：2001-04-05 00:00:00

abstract：:The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests t...

journal_title：Oncogene

authors： Peng A,Maller JL

更新日期：2010-11-11 00:00:00

abstract：:TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...

journal_title：Oncogene

authors： Clarke P,Meintzer SM,Spalding AC,Johnson GL,Tyler KL

更新日期：2001-10-18 00:00:00

abstract：:The ability of Src-family kinases (SFKs) to mediate signaling from cell surface receptors in hematopoietic cells is a function of their catalytic activity, location and binding partners. Kinase activity is regulated in the cell by kinases and phosphatases that alter the state of phosphorylation of key tyrosine residue...

journal_title：Oncogene

authors： Geahlen RL,Handley MD,Harrison ML

更新日期：2004-10-18 00:00:00

abstract：:A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains to be elucidated. I...

journal_title：Oncogene

authors： Yao R,Natsume Y,Noda T

更新日期：2004-08-12 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...

journal_title：Oncogene

authors： Morris SM,Mhyre AJ,Carmack SS,Myers CH,Burns C,Ye W,Ferrer M,Olson JM,Klinghoffer RA

更新日期：2018-08-01 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00

abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...

journal_title：Oncogene

authors： Chu Y,Chen Y,Guo H,Li M,Wang B,Shi D,Cheng X,Guan J,Wang X,Xue C,Cheng T,Shi J,Yuan W

更新日期：2020-12-01 00:00:00

abstract：:Much evidence has been gathered in support of a critical role for p53 in the cellular response to DNA damage. p53 dysfunction is associated with progression and poor prognosis of many human cancers and with a high incidence of tumours in p53 knockout mice. The absence of a p53-dependent G1 arrest that facilitates DNA ...

journal_title：Oncogene

authors： Griffiths SD,Clarke AR,Healy LE,Ross G,Ford AM,Hooper ML,Wyllie AH,Greaves M

更新日期：1997-02-06 00:00:00

abstract：:The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a reversal of methylation states. CpG island associated genes, in particular tumour suppressor or rel...

journal_title：Oncogene

authors： Clark SJ,Melki J

更新日期：2002-08-12 00:00:00

abstract：:Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...

journal_title：Oncogene

authors： Nie D,Shan X,Nie L,Duan Y,Chen Z,Yang Y,Li Z,Tian L,Gao Q,Shan Y,Tang N

更新日期：2016-07-14 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:Both chemokine receptors (CXCRs) 7 and 4 can facilitate immune cell migration and mediate a vast array of physiological and pathological events. Herein we report, in both human and animal studies, that these two CXCRs can form heterodimers in vivo and promote colorectal tumorigenesis through histone demethylation. Com...

journal_title：Oncogene

authors： Song ZY,Wang F,Cui SX,Gao ZH,Qu XJ

更新日期：2019-02-01 00:00:00

abstract：:The cellular transcription factor Brn-3a differentially regulates different human papilloma virus (HPV)-16 variants that are associated with different risks of progression to cervical carcinoma in infected humans. The upstream regulatory regions (URRs) of high- and intermediate-risk HPV-16 variants are activated by th...

journal_title：Oncogene

authors： Ndisang D,Khan A,Lorenzato F,Sindos M,Singer A,Latchman DS

更新日期：2010-05-06 00:00:00

abstract：:Fas signaling was reported to participate in cell apoptosis. However, this pathway has also been shown to promote tumor cell motility, leading to the hypothesis that Fas signaling may induce epithelial-mesenchymal transition (EMT) to promote metastasis. The effects of Fas-ligand (FasL) treatment and inhibition of Fas ...

journal_title：Oncogene

authors： Zheng HX,Cai YD,Wang YD,Cui XB,Xie TT,Li WJ,Peng L,Zhang Y,Wang ZQ,Wang J,Jiang B

更新日期：2013-02-28 00:00:00

abstract：:Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...

journal_title：Oncogene

authors： Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

更新日期：2010-06-03 00:00:00

abstract：:Receptor tyrosine kinases of the Eph family are upregulated in several different types of cancer. One family member in particular, the EphA2 receptor, has been linked to breast, prostate, lung and colon cancer, as well as melanoma. However, mechanisms by which EphA2 contributes to tumor progression are far from clear....

journal_title：Oncogene

authors： Fang WB,Brantley-Sieders DM,Parker MA,Reith AD,Chen J

更新日期：2005-11-24 00:00:00

abstract：:Heat shock protein 70 (HSP70) can inhibit apoptosis by neutralizing and interacting with apoptosis-inducing factor (AIF), a mitochondrial flavoprotein that translocates upon apoptosis induction to the nucleus, via the cytosol. Here, we show that only members of the HSP70 family interact with AIF. Systematic deletion m...

journal_title：Oncogene

authors： Gurbuxani S,Schmitt E,Cande C,Parcellier A,Hammann A,Daugas E,Kouranti I,Spahr C,Pance A,Kroemer G,Garrido C

更新日期：2003-10-02 00:00:00

abstract：:Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFβ-dependent biological outputs such as epithelial-mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isof...

journal_title：Oncogene

authors： Soond SM,Chantry A

更新日期：2011-05-26 00:00:00

abstract：:Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (...

journal_title：Oncogene

authors： Zhang H,Wong CC,Wei H,Gilkes DM,Korangath P,Chaturvedi P,Schito L,Chen J,Krishnamachary B,Winnard PT Jr,Raman V,Zhen L,Mitzner WA,Sukumar S,Semenza GL

更新日期：2012-04-05 00:00:00

abstract：:The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new stra...

journal_title：Oncogene

authors： Strand S,Vollmer P,van den Abeelen L,Gottfried D,Alla V,Heid H,Kuball J,Theobald M,Galle PR,Strand D

更新日期：2004-04-29 00:00:00

abstract：:Cancer cells recruit monocytes, macrophages and other inflammatory cells by producing abundant chemoattractants and growth factors, such as macrophage colony-stimulating factor (M-CSF/CSF-1) and monocyte chemoattractant protein-1 (MCP-1/CCL2), to promote tumor growth and dissemination. An understanding of the mechanis...

journal_title：Oncogene

authors： Li Y,Cai L,Wang H,Wu P,Gu W,Chen Y,Hao H,Tang K,Yi P,Liu M,Miao S,Ye D

更新日期：2011-09-08 00:00:00

abstract：:alpha-Catenin is an intracellular protein that associates with the carboxy-terminal region of cadherin, a cell adhesion molecule, via beta-catenin or gamma-catenin (plakoglobin). Linkage of cadherin to the cytoskeleton by catenins is required for full cadherin activity. Following transfection of an alpha-catenin-defic...

journal_title：Oncogene

authors： Matsubara S,Ozawa M

更新日期：2004-04-08 00:00:00

abstract：:Exposure of normal adult human skin to doses of UV irradiation that induced mild sunburn resulted in the rapid appearance of p53 protein in the epidermis and superficial dermal fibroblasts. Immunohistological analysis with a panel of antibodies established that while p53 staining was not seen in normal skin it appeare...

journal_title：Oncogene

authors： Hall PA,McKee PH,Menage HD,Dover R,Lane DP

更新日期：1993-01-01 00:00:00

abstract：:Activation of Stat5 by many cytokines implies that it cannot alone insure the specificity of the regulation of its target genes. We have evidenced a physical and functional interaction between members of two unrelated transcription factor families, Ets-1, Ets-2 and Stat5, which could contribute to the proliferative re...

journal_title：Oncogene

authors： Rameil P,Lécine P,Ghysdael J,Gouilleux F,Kahn-Perlès B,Imbert J

更新日期：2000-04-20 00:00:00