Abstract:
:The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.
journal_name
Oncogenejournal_title
Oncogeneauthors
Peng A,Maller JLdoi
10.1038/onc.2010.371subject
Has Abstractpub_date
2010-11-11 00:00:00pages
5977-88issue
45eissn
0950-9232issn
1476-5594pii
onc2010371journal_volume
29pub_type
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