CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis.

abstract：:The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases, have critical roles in animal physiology, and their deregulation is frequent in cancer. Here we report the identification of the guanine nucleotide exchange factor, phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger ...

journal_title：Oncogene

authors： Montero JC,Seoane S,Ocaña A,Pandiella A

更新日期：2011-03-03 00:00:00

abstract：:The fibroblast growth factor-binding protein (FGF-BP) modulates FGF activity through binding and release from the extracellular matrix. Consequently, the expression of FGF-BP in certain tumor types is a rate-limiting regulator of FGF-mediated angiogenesis. FGF-BP is upregulated in squamous cell carcinoma by treatment ...

journal_title：Oncogene

authors： Harris VK,Kagan BL,Ray R,Coticchia CM,Liaudet-Coopman ED,Wellstein A,Tate Riegel A

更新日期：2001-03-29 00:00:00

abstract：:Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...

journal_title：Oncogene

authors： Kang BS,French OG,Sando JJ,Hahn CS

更新日期：2000-08-31 00:00:00

abstract：:Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...

journal_title：Oncogene

authors： Patzke S,Hauge H,Sioud M,Finne EF,Sivertsen EA,Delabie J,Stokke T,Aasheim HC

更新日期：2005-02-10 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might be a key diver for the development of HCC. The mitochondrial amidoxime...

journal_title：Oncogene

authors： Wu D,Wang Y,Yang G,Zhang S,Liu Y,Zhou S,Guo H,Liang S,Cui Y,Zhang B,Ma K,Zhang C,Liu Y,Sun L,Wang J,Liu L

更新日期：2020-09-01 00:00:00

abstract：:The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...

journal_title：Oncogene

authors： Roth M,Chen WY

更新日期：2014-03-27 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5-12.5 days with associated defects in vasculogenesis. Whether Sag is required for de novo vasculogen...

journal_title：Oncogene

authors： Tan M,Li H,Sun Y

更新日期：2014-10-30 00:00:00

abstract：:Stimulation of resting W53 cells (lymphoid murine cells expressing prolactin (PRL) receptor) by PRL induced expression of growth-related immediate-early genes (IEG), and proliferation through activation of the Src kinases. Since IEG are essential for cell cycle progression, we have studied how PRL controls expression ...

journal_title：Oncogene

authors： Domínguez-Cáceres MA,García-Martínez JM,Calcabrini A,González L,Porque PG,León J,Martín-Pérez J

更新日期：2004-09-23 00:00:00

abstract：:Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the critical type-I PKA ...

journal_title：Oncogene

authors： Beristain AG,Molyneux SD,Joshi PA,Pomroy NC,Di Grappa MA,Chang MC,Kirschner LS,Privé GG,Pujana MA,Khokha R

更新日期：2015-02-26 00:00:00

abstract：:Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated that, in mouse embr...

journal_title：Oncogene

authors： Zeng Q,Chen J,Li Y,Werle KD,Zhao RX,Quan CS,Wang YS,Zhai YX,Wang JW,Youssef M,Cui R,Liang J,Genovese N,Chow LT,Li YL,Xu ZX

更新日期：2017-03-02 00:00:00

abstract：:Rel/NF-kappaB transcription factors are involved in several physiological processes, including the regulation of apoptosis. These factors were shown to exhibit pro- or anti-apoptotic activities in different cellular models, but at present, the mechanisms underlying these opposite effects are poorly understood. In this...

journal_title：Oncogene

authors： Bernard D,Monte D,Vandenbunder B,Abbadie C

更新日期：2002-06-27 00:00:00

abstract：:FHIT (Fragile Histidine Triad), a putative tumor suppressor gene, was cloned from fetal brain and colon cDNA libraries. Portions of this gene are deleted in esophageal, colon, lung and breast tumors, but this gene has not been found altered in sporadic renal cell carcinomas. We report here an alternatively spliced for...

journal_title：Oncogene

authors： Luan X,Shi G,Zohouri M,Paradee W,Smith DI,Decker HJ,Cannizzaro LA

更新日期：1997-07-03 00:00:00

abstract：:Overexpression of hepatocyte growth factor (HGF), also called scatter factor (SF), and its receptor c-Met are associated with poor prognosis for cancer patients. In particular, breast cancer cells can produce HGF that acts in a paracrine as well as in an autocrine manner. Therefore, HGF and c-Met are putative targets ...

journal_title：Oncogene

authors： Gallego MI,Bierie B,Hennighausen L

更新日期：2003-11-20 00:00:00

abstract：:Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ...

journal_title：Oncogene

authors： Saini U,Naidu S,ElNaggar AC,Bid HK,Wallbillich JJ,Bixel K,Bolyard C,Suarez AA,Kaur B,Kuppusamy P,Hays J,Goodfellow PJ,Cohn DE,Selvendiran K

更新日期：2017-01-12 00:00:00

abstract：:To dissect the p53-dependent apoptotic pathway, events following induction of temperature sensitive (ts) p53val138 were studied in a Ewing tumor cell line. Transcriptional deregulation of p53 targets first observable after 1 h at 32 degrees C preceded activation of caspases and the break-down of mitochondrial respirat...

journal_title：Oncogene

authors： Kovar H,Jug G,Printz D,Bartl S,Schmid G,Wesierska-Gadek J

更新日期：2000-08-24 00:00:00

abstract：:We have previously reported that there is a high incidence of microsatellite instability (MSI) and germline mismatch repair gene mutation in colorectal cancer arising from young Hong Kong Chinese. Most of the germline mutations involve hMSH2, which is different from the mutation spectrum in the Western population. It ...

journal_title：Oncogene

authors： Chan TL,Yuen ST,Ho JW,Chan AS,Kwan K,Chung LP,Lam PW,Tse CW,Leung SY

更新日期：2001-05-24 00:00:00

abstract：:The human tumor suppressor gene ataxia telangiectasia mutated (ATM) encodes a 3056 amino-acid protein kinase that regulates cell cycle checkpoints. ATM is defective in the neurodegenerative and cancer predisposition syndrome ataxia-telangiectasia. ATM protein kinase is activated by DNA damage and responds by phosphory...

journal_title：Oncogene

authors： Llorca O,Rivera-Calzada A,Grantham J,Willison KR

更新日期：2003-06-19 00:00:00

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:Ultraviolet light (UV) induced DNA lesions efficiently block transcript elongation and induce the p53 response. Although p53 contributes to transcriptional activation of the p21waf1 and bax genes, accumulation of these proteins requires that these genes are free of UV induced pyrimidine dimers. We assessed the level o...

journal_title：Oncogene

authors： McKay BC,Ljungman M,Rainbow AJ

更新日期：1998-08-06 00:00:00

abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...

journal_title：Oncogene

authors： Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

更新日期：2013-08-08 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:The cytoplasmic tyrosine kinase Src has been implicated in signal transduction induced by growth factors and integrins. Src also shows oncogenic activity when deregulated. Accumulating evidence indicates that the tyrosine kinase Abl is an important substrate for Src signalling in normal cells. Here we show that Abl is...

journal_title：Oncogene

authors： Sirvent A,Boureux A,Simon V,Leroy C,Roche S

更新日期：2007-11-15 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation of histone. Although histone H3 is known to be phosphorylated, the effect of acetylation on phosphorylation is not know...

journal_title：Oncogene

authors： Zhong S,Goto H,Inagaki M,Dong Z

更新日期：2003-08-14 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a...

journal_title：Oncogene

authors： Qin H,Malek S,Cowell JK,Ren M

更新日期：2016-10-27 00:00:00

abstract：:The products of ras and src proto-oncogenes are frequently activated in a constitutive state in human colorectal cancer. In this study we attempted to establish whether the tumorigenic progression induced by oncogenic activation of p21ras or pp60c-src in human colonic cells is associated with alterations of the activi...

journal_title：Oncogene

authors： Cadoret A,Bertrand F,Baron-Delage S,Lévy P,Courtois G,Gespach C,Capeau J,Cherqui G

更新日期：1997-04-03 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00

abstract：:Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated that nuclear ErbB-2 (NErbB-2) also plays a key role in BC and is a poor prognostic factor in ErbB...

journal_title：Oncogene

authors： Venturutti L,Romero LV,Urtreger AJ,Chervo MF,Cordo Russo RI,Mercogliano MF,Inurrigarro G,Pereyra MG,Proietti CJ,Izzo F,Díaz Flaqué MC,Sundblad V,Roa JC,Guzmán P,Bal de Kier Joffé ED,Charreau EH,Schillaci R,Elizalde PV

更新日期：2016-04-28 00:00:00

abstract：:It has been suggested that the embryonic microenvironment can control the survival and the transformed phenotype of tumour cells. Here, we addressed the hypothesis that the murine embryonic microenvironment can induce the differentiation of human tumour cells. To examine such interactions, we injected human leukaemic ...

journal_title：Oncogene

authors： Dürr M,Harder F,Merkel A,Bug G,Henschler R,Müller AM

更新日期：2003-12-11 00:00:00

abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

journal_title：Oncogene

authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

更新日期：2006-05-04 00:00:00