Down-regulation of NF-kappaB activity and NF-kappaB p65 subunit expression by ras and polyoma middle T oncogenes in human colonic Caco-2 cells.

abstract：:The human c-abl oncogene gives rise to different mRNA transcripts which vary primarily in that they possess alternative first exons. In the present study, we present the sequence for the human c-abl 3' untranslated region (3'utr) and show that while human and murine c-abl cDNA sequences are generally homologous, human...

journal_title：Oncogene

authors： Andrews DF 3rd,Tompkins CK,Hendrickson SL,Singer JW

更新日期：1990-03-01 00:00:00

abstract：:In contrast to the hereditary form of medullary thyroid carcinoma (MTC), little is known about the etiology of sporadic MTC. Somatic gain-of-function mutations in the RET proto-oncogene, encoding a receptor tyrosine kinase, are found in an average of 40% of sporadic MTC. We analysed 31 sporadic MTC for somatic and ger...

journal_title：Oncogene

authors： Gimm O,Dziema H,Brown J,Hoang-Vu C,Hinze R,Dralle H,Mulligan LM,Eng C

更新日期：2001-04-19 00:00:00

abstract：:Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures. Here, we show that distinct, stage-wise metabolic alterations in BLCA are associated with the loss of function of aldehyde oxidase (AOX1). AOX1 associated metabolites have a high predictive value for advanced BLCA an...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

journal_title：Oncogene

authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

更新日期：2000-02-10 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:Telomerase-negative cancer cells can maintain their telomeres by a recombination-mediated alternative lengthening of telomeres (ALT) process. We reported previously that sequestration of MRE11/RAD50/NBS1 complexes represses ALT-mediated telomere length maintenance, and suppresses formation of ALT-associated promyelocy...

journal_title：Oncogene

authors： Jiang WQ,Zhong ZH,Henson JD,Reddel RR

更新日期：2007-07-12 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

journal_title：Oncogene

authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

更新日期：1998-04-30 00:00:00

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 ...

journal_title：Oncogene

authors： Li DD,Wang LL,Deng R,Tang J,Shen Y,Guo JF,Wang Y,Xia LP,Feng GK,Liu QQ,Huang WL,Zeng YX,Zhu XF

更新日期：2009-02-12 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...

journal_title：Oncogene

authors： Mishra L,Tully RE,Monga SP,Yu P,Cai T,Makalowski W,Mezey E,Pavan WJ,Mishra B

更新日期：1997-11-06 00:00:00

abstract：:Uveal melanoma (UM) is a currently untreatable form of melanoma with a 50% mortality rate. Characterization of the essential signaling pathways driving this cancer is critical to develop target therapies. Activating mutations in the Gαq signaling pathway at the level of GNAQ, GNA11, or rarely CYSLTR2 or PLCβ4 are cons...

journal_title：Oncogene

authors： Ma J,Weng L,Bastian BC,Chen X

更新日期：2021-01-01 00:00:00

abstract：:The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...

journal_title：Oncogene

authors： Jung YK,Yuan J

更新日期：1997-03-13 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:Recently, we have cloned and characterized the Ras association domain family 1A gene (RASSF1A) at 3p21.3, from which loss of genetic material is one of the most frequent events in several types of human solid tumors. The CpG island promoter region of this gene is highly methylated in several human cancers, most notabl...

journal_title：Oncogene

authors： Liu L,Yoon JH,Dammann R,Pfeifer GP

更新日期：2002-10-03 00:00:00

abstract：:P53 wild-type and p53-null or mutant cells undergo a G(2)-phase cell-cycle arrest in response to ionizing radiation (IR). In this study we examined the effect of heat-shock protein 90 (HSP90) inhibitor, geldanamycin (GA), on IR-induced G(2) arrest in human colon adenocarcinoma cells with different p53 status. We show ...

journal_title：Oncogene

authors： Moran DM,Gawlak G,Jayaprakash MS,Mayar S,Maki CG

更新日期：2008-09-18 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene (mir-21) has been identified as the only miRNA commonly overexpressed in solid tumors of the lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pa...

journal_title：Oncogene

authors： Lu Z,Liu M,Stribinskis V,Klinge CM,Ramos KS,Colburn NH,Li Y

更新日期：2008-07-17 00:00:00

abstract：:Immunopurified mouse p53 proteins were used to gain experimental access to the mechanisms underlying nonprimate p53 directed suppression of SV40 origin directed DNA replication in vivo. In replication competent HeLa cell extracts containing exogenous T antigen, mouse p53 blocks T antigen dependent DNA synthesis as in ...

journal_title：Oncogene

authors： Stürzbecher HW,Brain R,Maimets T,Addison C,Rudge K,Jenkins JR

更新日期：1988-10-01 00:00:00

abstract：:The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new role for these proteins has been emerging as they have been linked with regulation of terminal differentiation of many tissues ...

journal_title：Oncogene

authors： Lipinski MM,Jacks T

更新日期：1999-12-20 00:00:00

abstract：:We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo fibroblasts. In accordance with previous work, we found that several functions were required. These include activities that map to the p53 binding domain and the...

journal_title：Oncogene

authors： Powell AJ,Darmon AJ,Gonos ES,Lam EW,Peden KW,Jat PS

更新日期：1999-12-02 00:00:00

abstract：:Mouse embryonic stem (ES) cells are known to express D-type cyclins at very low levels and these levels increase dramatically during in vitro and in vivo differentiation. Here, we investigate some of the signalling pathways regulating expression of cyclin D1 and progression to S phase, the Ras/Extracellular signal-reg...

journal_title：Oncogene

authors： Jirmanova L,Afanassieff M,Gobert-Gosse S,Markossian S,Savatier P

更新日期：2002-08-15 00:00:00

abstract：:Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...

journal_title：Oncogene

authors： Seo J,Lee EW,Shin J,Seong D,Nam YW,Jeong M,Lee SH,Lee C,Song J

更新日期：2018-09-01 00:00:00

abstract：:Mxi1 is a basic region helix-loop-helix leucine zipper (bHLH/LZ) protein that, in association with Max, antagonizes Myc oncogenic activities. A possible mechanistic basis for Mxi1-mediated repression was provided by the recent demonstration that the repressive potential of Mxi1 correlates with its ability to physicall...

journal_title：Oncogene

authors： Rao G,Alland L,Guida P,Schreiber-Agus N,Chen K,Chin L,Rochelle JM,Seldin MF,Skoultchi AI,DePinho RA

更新日期：1996-03-07 00:00:00

abstract：:Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF an...

journal_title：Oncogene

authors： Kim SW,Kim HJ,Jung DJ,Lee SK,Kim YS,Kim JH,Kim TS,Lee JW

更新日期：2001-10-04 00:00:00

abstract：:Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that medi...

journal_title：Oncogene

authors： Taki K,Ohmuraya M,Tanji E,Komatsu H,Hashimoto D,Semba K,Araki K,Kawaguchi Y,Baba H,Furukawa T

更新日期：2016-05-05 00:00:00

abstract：:Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evalu...

journal_title：Oncogene

authors： Hrstka R,Nenutil R,Fourtouna A,Maslon MM,Naughton C,Langdon S,Murray E,Larionov A,Petrakova K,Muller P,Dixon MJ,Hupp TR,Vojtesek B

更新日期：2010-08-26 00:00:00

abstract：:From the sequences of Rel/NF-kappa B and I kappa B proteins, we constructed an alignment of their Rel Homology Domain (RHD) and ankyrin repeat domain. Using this alignment, we performed tree reconstruction with both distance matrix and parsimony analysis and estimated the branching robustness using bootstrap resamplin...

journal_title：Oncogene

authors： Huguet C,Crepieux P,Laudet V

更新日期：1997-12-11 00:00:00