Microsatellite instability in prostate cancer.

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)...

journal_title：Oncogene

authors： Rybanska I,Ishaq O,Chou J,Prakash M,Bakhsheshian J,Huso DL,Franco S

更新日期：2013-04-04 00:00:00

abstract：:We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells. Here we have shown that FGFR1 is overexpressed in colorectal carcinoma cells and the gene expressions between FGFR1 and FGFR3 are mutually exclusive. Moreover, we have also shown that the disruption ...

journal_title：Oncogene

authors： Jang JH

更新日期：2005-01-27 00:00:00

abstract：:The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 gene in the tumorigenesis of hepatocellular carcinoma (HCC), 48 cases of HCC were analysed for p16 alterations...

journal_title：Oncogene

authors： Liew CT,Li HM,Lo KW,Leow CK,Chan JY,Hin LY,Lau WY,Lai PB,Lim BK,Huang J,Leung WT,Wu S,Lee JC

更新日期：1999-01-21 00:00:00

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown to be important in the regulation of proliferation and apoptosis. In this report, we investigated the role of the PKC-like kinase PKCmu in the control of these...

journal_title：Oncogene

authors： Trauzold A,Schmiedel S,Sipos B,Wermann H,Westphal S,Röder C,Klapper W,Arlt A,Lehnert L,Ungefroren H,Johannes FJ,Kalthoff H

更新日期：2003-12-04 00:00:00

abstract：:Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular cues and play a critica...

journal_title：Oncogene

authors： McKay MM,Morrison DK

更新日期：2007-05-14 00:00:00

abstract：:Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional regulation, which is a critical checkpoint to tune gene diversity and expression levels. We analyzed nuclear RBPs in human HCC tissues and matched normal control tissues. Based on the gene expression levels, PTBP3 was identified as top...

journal_title：Oncogene

authors： Yang X,Qu S,Wang L,Zhang H,Yang Z,Wang J,Dai B,Tao K,Shang R,Liu Z,Li X,Zhang Z,Xia C,Ma B,Liu W,Li H,Dou K

更新日期：2018-12-01 00:00:00

abstract：:UV irradiation of mammalian cells results in the activation of transcription factors which mediate induction of early response genes designed to repair and minimise the damage sustained by the cell. Evidence from studies in HeLa cells suggest that UVC regulates NF-kappa B activity via tyrosine kinases and activation o...

journal_title：Oncogene

authors： Tobin D,Nilsson M,Toftgård R

更新日期：1996-02-15 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:The overexpression or mutation of tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR), can lead to the development of cancer. The most common mutation of the EGFR in glioblastomas is the deletion of exons 2-7 known as the EGFRvIII. This mutant receptor cannot bind EGF but, instead, is constitut...

journal_title：Oncogene

authors： Davies GC,Ryan PE,Rahman L,Zajac-Kaye M,Lipkowitz S

更新日期：2006-10-19 00:00:00

abstract：:Ovarian cancer is currently the second leading cause of gynecological malignancy and cisplatin or cisplatin-based regimens have been the standard of care for the treatment of advance epithelial ovarian cancers. However, the efficacy of cisplatin treatment is often limited by the development of drug resistance either t...

journal_title：Oncogene

authors： Leong CT,Ong CK,Tay SK,Huynh H

更新日期：2007-02-08 00:00:00

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00

abstract：:Injection of the human neurotropic polyomavirus, JCV, into neonatal hamsters causes tumors of glial origin. Previously, a rapidly proliferating cell line, HJC-15, which expresses high levels of the viral T-antigen, had been established from JCV-induced hamster glial tumors. In our analyses of the mechanisms involved i...

journal_title：Oncogene

authors： Raj GV,Ansari SA,Khalili K

更新日期：1996-03-21 00:00:00

abstract：:Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...

journal_title：Oncogene

authors： Kanda N,Seno H,Konda Y,Marusawa H,Kanai M,Nakajima T,Kawashima T,Nanakin A,Sawabu T,Uenoyama Y,Sekikawa A,Kawada M,Suzuki K,Kayahara T,Fukui H,Sawada M,Chiba T

更新日期：2004-06-17 00:00:00

abstract：:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared wit...

journal_title：Oncogene

authors： Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi S

更新日期：2015-09-17 00:00:00

abstract：:Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as beta-catenin) endowed with both adhesion a...

journal_title：Oncogene

authors： Chiarugi P,Taddei ML,Schiavone N,Papucci L,Giannoni E,Fiaschi T,Capaccioli S,Raugei G,Ramponi G

更新日期：2004-05-13 00:00:00

abstract：:In classical Hodgkin lymphoma the malignant Hodgkin/Reed-Sternberg (HRS) cells characteristically constitute only a small minority of the tumour load. Their origin has been debated for decades, but on the basis of rearrangement and somatic hypermutations of their immunoglubulin (Ig) genes, HRS cells are now ascribed t...

journal_title：Oncogene

authors： Hertel CB,Zhou XG,Hamilton-Dutoit SJ,Junker S

更新日期：2002-07-25 00:00:00

abstract：:Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...

journal_title：Oncogene

authors： Renziehausen A,Wang H,Rao B,Weir L,Nigro CL,Lattanzio L,Merlano M,Vega-Rioja A,Del Carmen Fernandez-Carranco M,Hajji N,Matin R,Harwood C,Li S,Sim VR,O'Neill K,Evans A,Thompson A,Szlosarek P,Fleming C,Stebbing J,Pr

更新日期：2019-03-01 00:00:00

abstract：:Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents. Treatment of Ph-positive K562, TOM 1 and KCL-22 cells with etoposide for 2d induced cytosolic vacuolati...

journal_title：Oncogene

authors： Riordan FA,Bravery CA,Mengubas K,Ray N,Borthwick NJ,Akbar AN,Hart SM,Hoffbrand AV,Mehta AB,Wickremasinghe RG

更新日期：1998-03-26 00:00:00

abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

journal_title：Oncogene

authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

更新日期：2013-02-28 00:00:00

abstract：:Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Previously we have shown that FABP4 in endothelial cells is induced by the NOTCH1 signalling pathway, the latter of which is involved in mechanisms of resistance to antiangiogenic tumour therapy. Here, we...

journal_title：Oncogene

authors： Harjes U,Bridges E,Gharpure KM,Roxanis I,Sheldon H,Miranda F,Mangala LS,Pradeep S,Lopez-Berestein G,Ahmed A,Fielding B,Sood AK,Harris AL

更新日期：2017-02-16 00:00:00

abstract：:To investigate the mechanisms of colorectal carcinogenesis, we searched for genes regulated by adenomatous polyposis coli gene product (APC) and identified a novel gene, termed HELAD1 (helicase, APC down-regulated 1). A recombinant polypeptide representing the ATPases associated with cellular activities (AAA) domain o...

journal_title：Oncogene

authors： Ishiguro H,Shimokawa T,Tsunoda T,Tanaka T,Fujii Y,Nakamura Y,Furukawa Y

更新日期：2002-09-12 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 ...

journal_title：Oncogene

authors： Li DD,Wang LL,Deng R,Tang J,Shen Y,Guo JF,Wang Y,Xia LP,Feng GK,Liu QQ,Huang WL,Zeng YX,Zhu XF

更新日期：2009-02-12 00:00:00

abstract：:Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...

journal_title：Oncogene

authors： Patzke S,Hauge H,Sioud M,Finne EF,Sivertsen EA,Delabie J,Stokke T,Aasheim HC

更新日期：2005-02-10 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5-12.5 days with associated defects in vasculogenesis. Whether Sag is required for de novo vasculogen...

journal_title：Oncogene

authors： Tan M,Li H,Sun Y

更新日期：2014-10-30 00:00:00

abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

journal_title：Oncogene

authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

更新日期：2017-07-06 00:00:00

abstract：:Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilis...

journal_title：Oncogene

authors： Banks L,Barnett SC,Crook T

更新日期：1990-06-01 00:00:00

abstract：:Induction of apoptosis by adenovirus E1A in rodent cells is stimulated by wild type (wt) p53 but completely suppressed by mutated p53. The suppression is overcome by coexpression with Id proteins (Ids). The cells expressing E1A and Ids undergo apoptosis after accumulation in S phase, suggesting that S phase events are...

journal_title：Oncogene

authors： Yageta M,Tsunoda H,Yamanaka T,Nakajima T,Tomooka Y,Tsuchida N,Oda K

更新日期：1999-08-26 00:00:00

abstract：:Keratinocyte growth factor is a potent and specific mitogen for different types of epithelial cells, including keratinocytes of the skin. Furthermore, it has been implicated in morphogenetic processes of several organs. To further define the mechanisms of KGF action in the skin, we attempted to identify genes which ar...

journal_title：Oncogene

authors： Frank S,Munz B,Werner S

更新日期：1997-02-27 00:00:00