HPV-16 E7 functions at the G1 to S phase transition in the cell cycle.

abstract：:Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...

journal_title：Oncogene

authors： Ma YX,Tomita Y,Fan S,Wu K,Tong Y,Zhao Z,Song LN,Goldberg ID,Rosen EM

更新日期：2005-03-10 00:00:00

abstract：:By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one a...

journal_title：Oncogene

authors： Duh FM,Scherer SW,Tsui LC,Lerman MI,Zbar B,Schmidt L

更新日期：1997-09-25 00:00:00

abstract：:Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...

journal_title：Oncogene

authors： Zhang X,Yang L,Szeto P,Abali GK,Zhang Y,Kulkarni A,Amarasinghe K,Li J,Vergara IA,Molania R,Papenfuss AT,McLean C,Shackleton M,Harvey KF

更新日期：2020-07-01 00:00:00

abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

journal_title：Oncogene

authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

更新日期：2003-11-06 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:The growth and progression of prostate cancer are dependent on androgens and androgen receptor (AR), which act by modulating gene expression. Utilizing a gene microarray approach, we have identified the alpha1-subunit gene of soluble guanylyl cyclase (sGC) as a novel androgen-regulated gene. A heterodimeric cytoplasmi...

journal_title：Oncogene

authors： Cai C,Chen SY,Zheng Z,Omwancha J,Lin MF,Balk SP,Shemshedini L

更新日期：2007-03-08 00:00:00

abstract：:The trans-activator protein Tax of human T-cell leukemia virus type I (HTLV-I) plays an important role in the development of adult T-cell leukemia through, at least in part, its ability to stimulate cell growth. We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in hum...

journal_title：Oncogene

authors： Iwanaga R,Ohtani K,Hayashi T,Nakamura M

更新日期：2001-04-19 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:Mutations in mismatch repair (MMR) genes result in microsatellite instability (MSI) and early onset of colorectal cancer. To get mechanistic insights into the time scale, sequence and frequency of intestinal stem cell (ISC) transformation, we quantified MSI and growth characteristics of organoids of Msh2-deficient and...

journal_title：Oncogene

authors： Keysselt K,Kreutzmann T,Rother K,Kerner C,Krohn K,Przybilla J,Buske P,Löffler-Wirth H,Loeffler M,Galle J,Aust G

更新日期：2017-05-11 00:00:00

abstract：:Increasing evidence supports that long noncoding RNAs (lncRNAs) act as master regulators involved in tumorigenesis and development at the N6-methyladenine (m6A) epigenetic modification level. However, the underlying regulatory mechanism in breast cancer (BRCA) remains elusive. Here, we unveil that LINC00942 (LNC942) e...

journal_title：Oncogene

authors： Sun T,Wu Z,Wang X,Wang Y,Hu X,Qin W,Lu S,Xu D,Wu Y,Chen Q,Ding X,Guo H,Li Y,Wang Y,Fu B,Yao W,Wei M,Wu H

更新日期：2020-07-01 00:00:00

abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...

journal_title：Oncogene

authors： Park TJ,Curran T

更新日期：2014-10-23 00:00:00

abstract：:Growing evidence demonstrates that hepatitis B virus (HBV) integration and resulting insertional mutagenesis play an important role in cell growth or maintenance in hepatocellular carcinomas (HCCs). To determine if HBV integration occurs and affects cellular genes at such a stage of infection, we analysed viral-host j...

journal_title：Oncogene

authors： Minami M,Daimon Y,Mori K,Takashima H,Nakajima T,Itoh Y,Okanoue T

更新日期：2005-06-23 00:00:00

abstract：:In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...

journal_title：Oncogene

authors： Aouacheria A,Arnaud E,Venet S,Lalle P,Gouy M,Rigal D,Gillet G

更新日期：2001-09-13 00:00:00

abstract：:EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...

journal_title：Oncogene

authors： Squatrito M,Mancino M,Donzelli M,Areces LB,Draetta GF

更新日期：2004-05-27 00:00:00

abstract：:All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess direct...

journal_title：Oncogene

authors： Chen CF,Goyette P,Lohnes D

更新日期：2004-07-08 00:00:00

abstract：:Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed t...

journal_title：Oncogene

authors： Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F

更新日期：2006-03-09 00:00:00

abstract：:We have previously determined that the amplified DNA present in the HL60 promyelocytic leukaemia cell line contained 70 kb of continuous DNA sequences around the c-myc gene. In the work presented here we have further defined the HL60 amplicon and find it to be of the order of 160 kb and to contain a large region of DN...

journal_title：Oncogene

authors： Feo S,Di Liegro C,Mangano R,Read M,Fried M

更新日期：1996-10-03 00:00:00

abstract：:Although the prognosis of advanced extramammary Paget's disease (EMPD) is poor, there have been no preclinical research models for the development of novel therapeutics. This study aims to establish a preclinical research model for EMPD. We transplanted EMPD tissue into immunodeficient NOD/Scid mice. Histopathological...

journal_title：Oncogene

authors： Maeda T,Kitamura S,Nishihara H,Yanagi T

更新日期：2020-09-01 00:00:00

abstract：:The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...

journal_title：Oncogene

authors： Watson DK,Mavrothalassitis GJ,Jorcyk CL,Smyth FE,Papas TS

更新日期：1990-10-01 00:00:00

abstract：:Myc promotes both normal cell proliferation and oncogenic transformation through the activation and repression of target genes. The c-Myc-S protein is a truncated form of c-Myc that is produced in some cells from translation initiation at an internal AUG codon. We report that c-Myc-S and a similar truncated form of N-...

journal_title：Oncogene

authors： Cowling VH,Cole MD

更新日期：2008-02-21 00:00:00

abstract：:Ras genes are activated by point mutations at critical sites of their coding regions. Activated N-ras genes with transforming ability have been detected in patients with myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML) and in human myeloid cell lines. We used polymerase chain reaction (PCR), different...

journal_title：Oncogene

authors： Lübbert M,Jonas D,Miller CW,Herrmann F,Mertelsmann R,McCormick F,Koeffler HP

更新日期：1990-04-01 00:00:00

abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...

journal_title：Oncogene

authors： Crook T,Greenfield I,Howard J,Stanley M

更新日期：1990-04-01 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress protein HSP90 was demonstrated in vitro to inhibit T-cell activation and to modulate endoplasmic reticul...

journal_title：Oncogene

authors： Joly AL,Deepti A,Seignez A,Goloudina A,Hebrard S,Schmitt E,Richaud S,Fourmaux E,Hammann A,Collura A,Svrcek M,Jego G,Robinet E,Solary E,Demidov O,Kohli E,Garrido C

更新日期：2016-06-02 00:00:00

abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

journal_title：Oncogene

authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

更新日期：2014-03-20 00:00:00

abstract：:The transcript encoding endonuclein, the human homolog of yeast PWP1, was previously found up-regulated in pancreatic cancer tissue. By immunohistochemistry we detected a ubiquitous presence in several tissues examined: skin, liver, thyroid gland, heart muscle, neurons, kidney, bladder, pancreas, adrenal gland, ovary,...

journal_title：Oncogene

authors： Honoré B,Baandrup U,Nielsen S,Vorum H

更新日期：2002-02-07 00:00:00

abstract：:Branching morphogenesis within the peripubertal mouse mammary gland is directed by progesterone (P). A role for the homeobox-containing transcription factor, Msx2, during branching morphogenesis is suggested from its ontogenic expression profile and hormonal regulation. Herein, we define the spatio-temporal control of...

journal_title：Oncogene

authors： Satoh K,Hovey RC,Malewski T,Warri A,Goldhar AS,Ginsburg E,Saito K,Lydon JP,Vonderhaar BK

更新日期：2007-11-29 00:00:00

abstract：:As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional co...

journal_title：Oncogene

authors： de Bruijn DR,van Dijk AH,Willemse MP,van Kessel AG

更新日期：2008-01-24 00:00:00