CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis.

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...

journal_title：Oncogene

authors： Shiozawa T,Miyamoto T,Kashima H,Nakayama K,Nikaido T,Konishi I

更新日期：2004-11-11 00:00:00

abstract：:We compared the mitogenic and signaling pathways of three Fibroblast Growth Factor Receptors (FGFRs), FGFR1, KGFR and FGFR4 in the same cell line. Each receptor was expressed in L6E9 rat myoblasts that do not normally express detectable levels of FGFRs and clones that express comparable levels of each receptor were se...

journal_title：Oncogene

authors： Shaoul E,Reich-Slotky R,Berman B,Ron D

更新日期：1995-04-20 00:00:00

abstract：:Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...

journal_title：Oncogene

authors： Zhai Y,Iura A,Yeasmin S,Wiese AB,Wu R,Feng Y,Fearon ER,Cho KR

更新日期：2011-10-06 00:00:00

abstract：:A distinctive subset of renal carcinomas is associated with Xp11. 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors. We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion resulting from a t(X;17)(p1...

journal_title：Oncogene

authors： Argani P,Lui MY,Couturier J,Bouvier R,Fournet JC,Ladanyi M

更新日期：2003-08-14 00:00:00

abstract：:We have cloned a novel quail cDNA with strong homology to the pim family of proto-oncogenes. The deduced amino acid (aa) sequence of the cDNA, named qpim, is more closely related to Xenopus Pim and to the recently identified rat Pim-3 than to human or rodent Pim-1 or Pim-2. The protein encoded by the qpim cDNA can aut...

journal_title：Oncogene

authors： Eichmann A,Yuan L,Bréant C,Alitalo K,Koskinen PJ

更新日期：2000-02-24 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:Myxoid and round-cell liposarcomas share the translocation t(12;16)(q13;p11) creating the TLS-CHOP fusion gene as a common genetic alteration. We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence of consensus recogni...

journal_title：Oncogene

authors： Hosaka T,Kanoe H,Nakayama T,Murakami H,Yamamoto H,Nakamata T,Tsuboyama T,Oka M,Kasai M,Sasaki MS,Nakamura T,Toguchida J

更新日期：2000-11-23 00:00:00

abstract：:To achieve a better understanding of mechanisms that underlie hepatocarcinogenesis and to identify novel target molecules for diagnosis and therapy of hepatocellular carcinoma (HCC), we previously analysed gene-expression profiles of 20 HCC tissues on a cDNA microarray. Among the genes upregulated in the tumor tissues...

journal_title：Oncogene

authors： Silva FP,Hamamoto R,Furukawa Y,Nakamura Y

更新日期：2006-08-17 00:00:00

abstract：:Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression in OPM2 and delta47 human myeloma lines led to high Akt activity toward insulin-like growth factor I (...

journal_title：Oncogene

authors： Choi Y,Zhang J,Murga C,Yu H,Koller E,Monia BP,Gutkind JS,Li W

更新日期：2002-08-08 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...

journal_title：Oncogene

authors： Sato T,Nakashima A,Guo L,Coffman K,Tamanoi F

更新日期：2010-05-06 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) is a transcriptional coactivator for nuclear receptors and other transcription factors. AIB1 has an important role in malignancy of several cancers such as breast and prostate cancers. However, its involvement in human hepatocellular carcinoma (HCC) progression remains unclear. Here...

journal_title：Oncogene

authors： Xu Y,Chen Q,Li W,Su X,Chen T,Liu Y,Zhao Y,Yu C

更新日期：2010-06-10 00:00:00

abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...

journal_title：Oncogene

authors： Hodge DR,Robinson L,Watson D,Lautenberger J,Zhang XK,Venanzoni M,Seth A

更新日期：1996-01-04 00:00:00

abstract：:We have examined the mitogenic potential of platelet-derived growth factor (PDGF) on AIDS (acquired immune deficiency syndrome)-related and sporadic Kaposi's sarcoma cells in comparison to fibroblasts at physiological and subphysiological calcium concentrations of the culture medium. At low calcium concentrations in t...

journal_title：Oncogene

authors： Roth WK,Werner S,Schirren CG,Hofschneider PH

更新日期：1989-04-01 00:00:00

abstract：:Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cel...

journal_title：Oncogene

authors： Yatabe Y,Mitsudomi T,Takahashi T

更新日期：2004-05-20 00:00:00

abstract：:The transformation suppressor gene, programmed cell death gene 4 (Pdcd4), inhibits tumor-promoter-mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer. The Pdcd4 protein interacts with translation initiation factors eIF4A and eIF4G and bin...

journal_title：Oncogene

authors： Bitomsky N,Wethkamp N,Marikkannu R,Klempnauer KH

更新日期：2008-08-14 00:00:00

abstract：:We have isolated a gene (WS5) that is specifically expressed at the mRNA and protein level in avian fibroblasts transformed by the v-myc oncogene of avian acute leukemia virus MC29. In a conditional cell transformation system, WS5 gene expression was tightly correlated with v-myc activation. The WS5 gene contains 11 e...

journal_title：Oncogene

authors： Reiter F,Hartl M,Karagiannidis AI,Bister K

更新日期：2007-03-15 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...

journal_title：Oncogene

authors： Joseph J,Radulovich N,Wang T,Raghavan V,Zhu CQ,Tsao MS

更新日期：2020-01-01 00:00:00

abstract：:Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...

journal_title：Oncogene

authors： Roberts T,Cowell JK

更新日期：1997-02-27 00:00:00

abstract：:AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind...

journal_title：Oncogene

authors： Wu M,Xu LG,Su T,Tian Y,Zhai Z,Shu HB

更新日期：2004-09-02 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....

journal_title：Oncogene

authors： Rataj F,Planel S,Denis J,Roelants C,Filhol O,Guyon L,Feige JJ,Cherradi N

更新日期：2019-06-01 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD family of calcium-calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and PKD3. PKD2 is activated by many stimuli including growth factors, phorbol esters, and G-protein-coupled receptor agonists. PKD2 participation to uncontroll...

journal_title：Oncogene

authors： Azoitei N,Cobbaut M,Becher A,Van Lint J,Seufferlein T

更新日期：2018-03-01 00:00:00

abstract：:The whey acidic protein (WAP) domain is a conserved motif, containing eight cysteines found in a characteristic 4-disulphide core arrangement, that is present in a number of otherwise unrelated proteins. WAP motifs are present in SLPI and elafin, two antiproteinases located on chromosome 20q12-13, in a locus rich in p...

journal_title：Oncogene

authors： Bingle L,Singleton V,Bingle CD

更新日期：2002-04-18 00:00:00

abstract：:We have isolated mouse cDNA clones encoding Tyro 3, a receptor protein-tyrosine kinase (PTK) of the mammalin central nervous system (CNS). Expression of the Tyro 3 gene is strongly up-regulated in neurons of the mouse neocortex, cerebellum, and hippocampus after the day of birth, during periods of active synaptogenesi...

journal_title：Oncogene

authors： Lai C,Gore M,Lemke G

更新日期：1994-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF) induces both cell death and survival signals. NF-kappaB, a transcription factor activated by TNF, is critical for controlling survival signals through trans-activation of downstream target genes. However, few NF-kappaB target survival genes have been identified with direct roles in oncogene...

journal_title：Oncogene

authors： Au PY,Martin N,Chau H,Moemeni B,Chia M,Liu FF,Minden M,Yeh WC

更新日期：2005-04-28 00:00:00

abstract：:Exposure of normal adult human skin to doses of UV irradiation that induced mild sunburn resulted in the rapid appearance of p53 protein in the epidermis and superficial dermal fibroblasts. Immunohistological analysis with a panel of antibodies established that while p53 staining was not seen in normal skin it appeare...

journal_title：Oncogene

authors： Hall PA,McKee PH,Menage HD,Dover R,Lane DP

更新日期：1993-01-01 00:00:00

abstract：:We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors contain three immunoglobulin (Ig)-like domains and an unusual acidic motif in the extracellular region, a single transmembrane segment and a protein tyrosine kinase c...

journal_title：Oncogene

authors： Crumley G,Bellot F,Kaplow JM,Schlessinger J,Jaye M,Dionne CA

更新日期：1991-12-01 00:00:00