siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression.

abstract：:Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...

journal_title：Oncogene

authors： Kang BS,French OG,Sando JJ,Hahn CS

更新日期：2000-08-31 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for...

journal_title：Oncogene

authors： Berretta M,Cinelli R,Martellotta F,Spina M,Vaccher E,Tirelli U

更新日期：2003-09-29 00:00:00

abstract：:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protei...

journal_title：Oncogene

authors： Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto T

更新日期：2007-05-03 00:00:00

abstract：:Tumor cells, stromal cell compartment and the extracellular matrix (ECM) together generate a multifaceted tumor microenvironment. Matrix metalloproteinases and their tissue inhibitors (TIMPs) provide a means for tumor-stromal interaction during tumorigenesis. Among TIMPs, TIMP-3 is uniquely localized to the ECM and is...

journal_title：Oncogene

authors： Cruz-Muñoz W,Kim I,Khokha R

更新日期：2006-01-26 00:00:00

abstract：:Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 bu...

journal_title：Oncogene

authors： Chen Q,Ash JD,Branton P,Fromm L,Overbeek PA

更新日期：2002-02-07 00:00:00

abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

journal_title：Oncogene

authors： Snijders AJ,Haase VH,Bernards A

更新日期：1993-01-01 00:00:00

abstract：:Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown t...

journal_title：Oncogene

authors： Wang L,Soria JC,Chang YS,Lee HY,Wei Q,Mao L

更新日期：2003-10-16 00:00:00

abstract：:CD44 is a cell surface receptor for hyaluronate, a component of the extracellular matrix (ECM). Although CD44 has been implicated in tumor invasion and metastasis, the molecular mechanisms remain to be elucidated. Here we find that CD44 expressed in cancer cells is cleaved at the membrane-proximal region of the ectodo...

journal_title：Oncogene

authors： Okamoto I,Kawano Y,Tsuiki H,Sasaki J,Nakao M,Matsumoto M,Suga M,Ando M,Nakajima M,Saya H

更新日期：1999-02-18 00:00:00

abstract：:A new region of the adenovirus E1a protein essential for immortalization and transformation of primary rat kidney cells has been identified. This region is located between amino acid residues 18 to 20 in an N-terminal domain that is not conserved among the various adenovirus serotypes. The transformation defective mut...

journal_title：Oncogene

authors： Subramanian T,Kuppuswamy M,Nasr RJ,Chinnadurai G

更新日期：1988-02-01 00:00:00

abstract：:We have cloned the rat homolog of the human leukocyte common antigen-related gene (LAR), which encodes a transmembrane receptor phosphotyrosine phosphatase, and raised antibodies against its protein product. We present evidence here for a processing event resulting in a two-chain structure of the mature receptor on th...

journal_title：Oncogene

authors： Yu Q,Lenardo T,Weinberg RA

更新日期：1992-06-01 00:00:00

abstract：:Knowledge of tumour initiation in human epithelia is limited by sample availability and difficulty in experimental manipulation of human cells. The thyroid is a useful model since, in addition to multiple tumour stages, it presents two distinct 'pathways' of tumorigenesis: 'follicular' tumours, in which ras oncogene m...

journal_title：Oncogene

authors： Bond JA,Wyllie FS,Rowson J,Radulescu A,Wynford-Thomas D

更新日期：1994-01-01 00:00:00

abstract：:Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth, differentiation and cell migration. In this study, we show that mammalian target of rapamycin complex 2 (mTORC2) regulates invasive cancer cell migration through selective activation of Akt1. Insuli...

journal_title：Oncogene

authors： Kim EK,Yun SJ,Ha JM,Kim YW,Jin IH,Yun J,Shin HK,Song SH,Kim JH,Lee JS,Kim CD,Bae SS

更新日期：2011-06-30 00:00:00

abstract：:DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of cyclobutane pyrimidine dimers (CPDs), and is regulated by p53 in human cells. We show that DDB2 is expressed in mouse tissues and demonstrate, using primary mouse epithelial cells, that mouse DDB2 is regulated by E2F tr...

journal_title：Oncogene

authors： Prost S,Lu P,Caldwell H,Harrison D

更新日期：2007-05-24 00:00:00

abstract：:Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in glycolysis. Regeneration of the NAD required to support enhanced glycolysis has been attributed to the terminal ...

journal_title：Oncogene

authors： Hanse EA,Ruan C,Kachman M,Wang D,Lowman XH,Kelekar A

更新日期：2017-07-06 00:00:00

abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

journal_title：Oncogene

authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

更新日期：2001-11-29 00:00:00

abstract：:MyD88 was first characterized as a myeloid differentiation primary response gene in mice, activated in M1 myeloleukemic cells following interleukin-6 (IL-6) induced growth arrest and terminal differentiation. Analysis of expressed sequence tags (ESTs) from activated dendritic cell libraries led to the indentification ...

journal_title：Oncogene

authors： Hardiman G,Rock FL,Balasubramanian S,Kastelein RA,Bazan JF

更新日期：1996-12-05 00:00:00

abstract：:Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...

journal_title：Oncogene

authors： Tada Y,Yamaguchi Y,Kinjo T,Song X,Akagi T,Takamura H,Ohta T,Yokota T,Koide H

更新日期：2015-02-05 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and multiple evidence has confirmed that C5a production is elevated in NSCLC microenvironment. Although NSCLC cell proliferation induced by C5a has been reported, the involved mechanism has not been elucidated. In this study, we examined the pr...

journal_title：Oncogene

authors： Zhao C,Li Y,Qiu W,He F,Zhang W,Zhao D,Zhang Z,Zhang E,Ma P,Liu Y,Ma L,Yang F,Wang Y,Shu Y

更新日期：2018-08-01 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...

journal_title：Oncogene

authors： Fulda S

更新日期：2014-02-06 00:00:00

abstract：:Overexpression of the nuclear phosphoprotein p53 has been detected in many different transformed human cell lines and primary adult tumors. Elevated steady-state levels of p53 appear to be the result of an increase in the stability of the protein and, in adult cancers, high levels of the protein are associated with mu...

journal_title：Oncogene

authors： Davidoff AM,Pence JC,Shorter NA,Iglehart JD,Marks JR

更新日期：1992-01-01 00:00:00

abstract：:A series of primary human breast tumors was analysed by immunoblotting with anti-neu antibodies. Overproduction of the neu protein-tyrosine kinase, p185neu, was observed in 23 of 56 malignant tumor samples. 29 of these tumors were also immunoblotted with antiphosphotyrosine antibodies. A single prominent phosphotyrosi...

journal_title：Oncogene

authors： Wildenhain Y,Pawson T,Blackstein ME,Andrulis IL

更新日期：1990-06-01 00:00:00

abstract：:The VN-11 recombinant retroviruses, originally generated by co-transfection of the avian MH2 and AKRv viral genomes, were molecularly cloned from an infected mouse cell line named N11. The analysis of the proviral genome sequence from one of these recombinants showed a possible envAKR-mycMH2 fusion. Point mutations we...

journal_title：Oncogene

authors： Sassano M,Granucci F,Seveso M,Marconi G,Foti M,Ricciardi-Castagnoli P

更新日期：1994-05-01 00:00:00

abstract：:Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions in...

journal_title：Oncogene

authors： Godthelp BC,Artwert F,Joenje H,Zdzienicka MZ

更新日期：2002-07-25 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:beta-catenin activation, and subsequent upregulation of Wnt-signaling, is an important event in the development of certain human and rodent cancers. Recently, mutations in the beta-catenin gene in the region of the serine-threonine glycogen kinase (GSK)-3beta phosphorylation target sites have been identified in hepato...

journal_title：Oncogene

authors： Devereux TR,Anna CH,Foley JF,White CM,Sills RC,Barrett JC

更新日期：1999-08-19 00:00:00

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:rho genes have been found in both lower and higher eucaryotes. They code for proteins of 21 kDa, highly conserved in evolution, which belong to the superfamily of ras GTPases. Among the members of this superfamily there are proteins with a regulatory function, such as ras, and proteins involved in vesicular traffickin...

journal_title：Oncogene

authors： Perona R,Esteve P,Jiménez B,Ballestero RP,Ramón y Cajal S,Lacal JC

更新日期：1993-05-01 00:00:00

abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

journal_title：Oncogene

authors： Ego T,Tanaka Y,Shimotohno K

更新日期：2005-03-10 00:00:00