HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1.

abstract：:The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and persistence of an early...

journal_title：Oncogene

authors： Fischer M,Schwieger M,Horn S,Niebuhr B,Ford A,Roscher S,Bergholz U,Greaves M,Löhler J,Stocking C

更新日期：2005-11-17 00:00:00

abstract：:Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents. Treatment of Ph-positive K562, TOM 1 and KCL-22 cells with etoposide for 2d induced cytosolic vacuolati...

journal_title：Oncogene

authors： Riordan FA,Bravery CA,Mengubas K,Ray N,Borthwick NJ,Akbar AN,Hart SM,Hoffbrand AV,Mehta AB,Wickremasinghe RG

更新日期：1998-03-26 00:00:00

abstract：:Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the phosphorylation of the s...

journal_title：Oncogene

authors： Spicer J,Rayter S,Young N,Elliott R,Ashworth A,Smith D

更新日期：2003-07-24 00:00:00

abstract：:Stimulation of the endometrium by estrogens without the differentiating effect of progestins is the primary etiological factor associated with the development of endometrial hyperplasia and adenocarcinoma. However, the correlation between sex steroids and gap junctional intercellular communication (GJIC), which is con...

journal_title：Oncogene

authors： Saito T,Tanaka R,Wataba K,Kudo R,Yamasaki H

更新日期：2004-02-05 00:00:00

abstract：:Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...

journal_title：Oncogene

authors： Fulda S

更新日期：2014-02-06 00:00:00

abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

journal_title：Oncogene

authors： Roussel MF,Downing JR,Sherr CJ

更新日期：1990-01-01 00:00:00

abstract：:The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated ...

journal_title：Oncogene

authors： Nguyen-Khac F,Della Valle V,Lopez RG,Ravet E,Mauchauffé M,Friedman AD,Huang LE,Fichelson S,Ghysdael J,Bernard OA

更新日期：2006-08-10 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:Resistance to TGF-beta1 occurred in pancreatic cancer cells suggesting that inactivation of TGF-beta inhibitory signaling pathways may play an important role in human pancreatic cancer. The aim of our study was to determine the presence of alterations in the main putative components of the TGF-beta inhibitory signalin...

journal_title：Oncogene

authors： Villanueva A,García C,Paules AB,Vicente M,Megías M,Reyes G,de Villalonga P,Agell N,Lluís F,Bachs O,Capellá G

更新日期：1998-10-15 00:00:00

abstract：:dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...

journal_title：Oncogene

authors： FitzGerald MJ,Arsura M,Bellas RE,Yang W,Wu M,Chin L,Mann KK,DePinho RA,Sonenshein GE

更新日期：1999-04-15 00:00:00

abstract：:The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...

journal_title：Oncogene

authors： Mo YY,Yu Y,Theodosiou E,Ee PL,Beck WT

更新日期：2005-04-14 00:00:00

abstract：:The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...

journal_title：Oncogene

authors： Du L,Zhao Z,Ma X,Hsiao TH,Chen Y,Young E,Suraokar M,Wistuba I,Minna JD,Pertsemlidis A

更新日期：2014-08-21 00:00:00

abstract：:Rel/NF-kappaB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of biological factors and environmental conditions can lead to the activation of Rel/NF-kappaB dimers by signaling degradation ...

journal_title：Oncogene

authors： Chen FE,Ghosh G

更新日期：1999-11-22 00:00:00

abstract：:The T-box transcription factor TBX3 has been implicated in the patterning and differentiation of a number of tissues during embryonic development, and is overexpressed in a variety of cancers; however, the precise function of TBX3 in papillary thyroid carcinoma (PTC) development remains to be determined. In the curren...

journal_title：Oncogene

authors： Li X,Ruan X,Zhang P,Yu Y,Gao M,Yuan S,Zhao Z,Yang J,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...

journal_title：Oncogene

authors： Ingvarsson S,Sundaresan S,Jin P,Francke U,Asker C,Sümegi J,Klein G,Sejersen T

更新日期：1988-12-01 00:00:00

abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...

journal_title：Oncogene

authors： Bossi G,Mazzaro G,Porrello A,Crescenzi M,Soddu S,Sacchi A

更新日期：2004-01-15 00:00:00

abstract：:The myb proto oncogene product (c-Myb) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis. It has been shown [Venturelli, D., Travali, S. & Calabretta, B. (1990). Proc. Natl. Acad. Sci. USA, 87, 5963-5967] that inhibition of T-cell pro...

journal_title：Oncogene

authors： Sudo T,Miyazawa H,Hanaoka F,Ishii S

更新日期：1992-10-01 00:00:00

abstract：:The c-myb gene is the normal cellular homolog of v-myb, the oncogenic component of Avian Myeloblastosis Virus (AMV). The c-myb gene has previously been shown to code for a single protein species of about 75 kd. However, accumulating evidence indicates that this gene could code for multiple mRNAs as a result of differe...

journal_title：Oncogene

authors： Dudek H,Reddy EP

更新日期：1989-09-01 00:00:00

abstract：:Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...

journal_title：Oncogene

authors： Ciossek T,Ullrich A

更新日期：1997-01-09 00:00:00

abstract：:The establishment of a system for in vitro clonal development of hematopoietic cells made it possible to discover the cytokines that regulate hematopoiesis. These cytokines include colony stimulating factors and others, which interact in a network, and there is a cytokine cascade which couples growth and differentiati...

journal_title：Oncogene

authors： Lotem J,Sachs L

更新日期：2002-05-13 00:00:00

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a short chain fatty acid, is a HDAC inhibitor and is produced in the colonic lumen as a consequence of microbial degradation of dietary fibers. In order to dissect out the mechanism of Na...

journal_title：Oncogene

authors： Joseph J,Mudduluru G,Antony S,Vashistha S,Ajitkumar P,Somasundaram K

更新日期：2004-08-19 00:00:00

abstract：:Pancreatic cancer still remains one of the most lethal diseases and establishment of new therapy is needed. The purpose of this study is to find novel factors involved in pancreatic cancer progression by proteomic approach. We compared pre- and postoperative serum protein profiling obtained from pancreatic cancer pati...

journal_title：Oncogene

authors： Takano S,Yoshitomi H,Togawa A,Sogawa K,Shida T,Kimura F,Shimizu H,Tomonaga T,Nomura F,Miyazaki M

更新日期：2008-05-01 00:00:00

abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...

journal_title：Oncogene

authors： Guo L,Chen C,Shi M,Wang F,Chen X,Diao D,Hu M,Yu M,Qian L,Guo N

更新日期：2013-11-07 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:The p53 tumour suppressor is involved in several crucial cellular functions including cell-cycle arrest and apoptosis. p53 stabilization occurs under hypoxic and DNA damage conditions. However, only in the latter scenario is stabilized p53 capable of inducing the expression of its pro-apoptotic targets. Here we presen...

journal_title：Oncogene

authors： Xenaki G,Ontikatze T,Rajendran R,Stratford IJ,Dive C,Krstic-Demonacos M,Demonacos C

更新日期：2008-10-02 00:00:00

abstract：:Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in part through activation of the STAT transcription factor family. In particular, various isoforms of STAT3 and STAT5 are activated during myeloid differentiation in...

journal_title：Oncogene

authors： Coffer PJ,Koenderman L,de Groot RP

更新日期：2000-05-15 00:00:00

abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

journal_title：Oncogene

authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

更新日期：2018-02-22 00:00:00

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00