Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00

abstract：:We have sought to identify and isolate target genes for the zinc finger protein, EVI-1, which has been implicated in the genesis of myelogenous leukemia both in mouse and human. We have approached this with a two-step selection: we first selected for genomic fragments of mouse DNA that bind to the protein with high af...

journal_title：Oncogene

authors： Kim JH,Hui P,Yue D,Aycock J,Leclerc C,Bjoring AR,Perkins AS

更新日期：1998-09-24 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:Germline mutations of the RET proto-oncogene are responsible for the familial tumor syndrome called multiple endocrine neoplasia type 2 (MEN 2) that includes medullary thyroid carcinoma (MTC). Although inherited mutations of RET lead to tumor formation in patients with MEN 2, it is not understood why only selected cel...

journal_title：Oncogene

authors： Koch CA,Huang SC,Moley JF,Azumi N,Chrousos GP,Gagel RF,Zhuang Z,Pacak K,Vortmeyer AO

更新日期：2001-11-22 00:00:00

abstract：:To study the interplay of steroid hormones and oncogenes in the control of endometrial cell proliferation and differentiation we have generated cell lines derived from rat endometrium by expressing the immortalizing oncogenes adeno E1A or SV40 large T antigen. These lines are positive for mesenchymal markers and conta...

journal_title：Oncogene

authors： Helftenbein G,Alvarez CV,Tuohimaa P,Beato M

更新日期：1993-08-01 00:00:00

abstract：:Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in part through activation of the STAT transcription factor family. In particular, various isoforms of STAT3 and STAT5 are activated during myeloid differentiation in...

journal_title：Oncogene

authors： Coffer PJ,Koenderman L,de Groot RP

更新日期：2000-05-15 00:00:00

abstract：:The PLZF gene was identified first by its fusion with the retinoic acid receptor alpha gene in the t(11;17) translocation associated with a retinoic acid resistant form of acute promyelocytic leukemia (APL). It encodes a krüppel-like zinc finger protein with a POZ domain shared with a subset of regulatory proteins inc...

journal_title：Oncogene

authors： David G,Alland L,Hong SH,Wong CW,DePinho RA,Dejean A

更新日期：1998-05-14 00:00:00

abstract：:Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...

journal_title：Oncogene

authors： Beyne-Rauzy O,Recher C,Dastugue N,Demur C,Pottier G,Laurent G,Sabatier L,Mansat-De Mas V

更新日期：2004-09-30 00:00:00

abstract：:Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...

journal_title：Oncogene

authors： Cheng L,Zhou Z,Flesken-Nikitin A,Toshkov IA,Wang W,Camps J,Ried T,Nikitin AY

更新日期：2010-10-21 00:00:00

abstract：:Although cyclin D1 is overexpressed in a significant number of human cancers, overexpression alone is insufficient to promote tumorigenesis. In vitro studies have revealed that inhibition of cyclin D1 nuclear export unmasks its neoplastic potential. Cyclin D1 nuclear export depends upon phosphorylation of a C-terminal...

journal_title：Oncogene

authors： Benzeno S,Lu F,Guo M,Barbash O,Zhang F,Herman JG,Klein PS,Rustgi A,Diehl JA

更新日期：2006-10-12 00:00:00

abstract：:Signature abnormalities in the cell cycle and apoptotic pathway have been identified in mantle cell lymphoma (MCL), affording the opportunity to develop targeted therapies. In this study, we tested a novel class of kinase inhibitors, styryl sulfones, which differ from prior cell cycle inhibitors in that they are not r...

journal_title：Oncogene

authors： Park IW,Reddy MV,Reddy EP,Groopman JE

更新日期：2007-08-16 00:00:00

abstract：:In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms cells to an addicted state that requires glucose metabolism for survival. We investigated S6K1, a protein kinase that drives glycolysis in leukemia cells, as a target for counteracting glucose-dependent survival induced by BC...

journal_title：Oncogene

authors： Barger JF,Gallo CA,Tandon P,Liu H,Sullivan A,Grimes HL,Plas DR

更新日期：2013-01-24 00:00:00

abstract：:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently...

journal_title：Oncogene

authors： Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OA

更新日期：1998-06-04 00:00:00

abstract：:Twenty five human glial tumours of different grades of malignancy were examined by Southern blotting and polymerase chain reaction (PCR) for alterations (rearrangements, amplification and deletions) in the c-myc gene. Number of c-myc positive cells per thousand cells were also counted in all the tumours after immunohi...

journal_title：Oncogene

authors： Chattopadhyay P,Banerjee M,Sarkar C,Mathur M,Mohapatra AK,Sinha S

更新日期：1995-12-21 00:00:00

abstract：:Stimulation of the endometrium by estrogens without the differentiating effect of progestins is the primary etiological factor associated with the development of endometrial hyperplasia and adenocarcinoma. However, the correlation between sex steroids and gap junctional intercellular communication (GJIC), which is con...

journal_title：Oncogene

authors： Saito T,Tanaka R,Wataba K,Kudo R,Yamasaki H

更新日期：2004-02-05 00:00:00

abstract：:Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signaling pathway...

journal_title：Oncogene

authors： Steinhäuser K,Klöble P,Kreis NN,Ritter A,Friemel A,Roth S,Reichel JM,Michaelis J,Rieger MA,Louwen F,Oswald F,Yuan J

更新日期：2017-04-01 00:00:00

abstract：:The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25-30% of acute myeloid leukaemia (AML) patients. Most common are internal tandem duplications of sequence (ITD) leading to constitutive FLT3-ITD kinase activity with an altered signalling qua...

journal_title：Oncogene

authors： Kresinsky A,Schnöder TM,Jacobsen ID,Rauner M,Hofbauer LC,Ast V,König R,Hoffmann B,Svensson CM,Figge MT,Hilger I,Heidel FH,Böhmer FD,Müller JP

更新日期：2019-06-01 00:00:00

abstract：:To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure. NMuMG cells became proliferation-arrested and apoptotic after exposure to TGFbeta for 2-5 days, w...

journal_title：Oncogene

authors： Gal A,Sjöblom T,Fedorova L,Imreh S,Beug H,Moustakas A

更新日期：2008-02-21 00:00:00

abstract：:The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few a...

journal_title：Oncogene

authors： Fedorenko IV,Gibney GT,Smalley KS

更新日期：2013-06-20 00:00:00

abstract：:Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their expression in cancers has not been ex...

journal_title：Oncogene

authors： Park J,Song SH,Kim TY,Choi MC,Jong HS,Kim TY,Lee JW,Kim NK,Kim WH,Bang YJ

更新日期：2004-04-22 00:00:00

abstract：:The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and persistence of an early...

journal_title：Oncogene

authors： Fischer M,Schwieger M,Horn S,Niebuhr B,Ford A,Roscher S,Bergholz U,Greaves M,Löhler J,Stocking C

更新日期：2005-11-17 00:00:00

abstract：:Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...

journal_title：Oncogene

authors： Matteucci E,Modora S,Simone M,Desiderio MA

更新日期：2003-06-26 00:00:00

abstract：:The expression of the monocyte-chemoattractant-protein-1 (MCP-1) is closely linked with a non-tumorigenic phenotype in somatic cell hybrids made between the human papillomavirus type 18 (HPV 18) positive cervical carcinoma cell line HeLa and normal human fibroblasts. In contrast, MCP-1 transcription is absent in tumor...

journal_title：Oncogene

authors： Finzer P,Soto U,Delius H,Patzelt A,Coy JF,Poustka A,zur Hausen H,Rösl F

更新日期：2000-07-06 00:00:00

abstract：:Appropriate expression of HTLV-1 genes requires transcriptional transactivation by Tax and post-transcriptional regulation by Rex, both mediated by LTR encoded RNA sequences. Using a combination of deletion mutagenesis, Rex-reporter CAT assays, fluorescence in situ hybridization (FISH) and confocal laser scanning micr...

journal_title：Oncogene

authors： King JA,Bridger JM,Löchelt M,Lichter P,Schulz TF,Schirrmacher V,Khazaie K

更新日期：1998-06-25 00:00:00

abstract：:The quail Pax-6 gene is expressed from two promoters named P0 and P1. P0 promoter is under the control of a neuroretina-specific enhancer (EP). This enhancer activates the P0 promoter specifically in neuroretina cells and in a developmental stage-dependent manner. The EP enhancer binds efficiently, as revealed by sout...

journal_title：Oncogene

authors： Plaza S,Aumercier M,Bailly M,Dozier C,Saule S

更新日期：1999-01-28 00:00:00

abstract：:Human telomerase is a unique reverse transcriptase that is expressed in multiple cancers, but not in the vast majority of normal cells. The enzyme is responsible for telomere protection and maintenance, and supports the proliferative immortality of cancer cells. Thus, it has been proposed that the specific inhibition ...

journal_title：Oncogene

authors： Herbert BS,Pongracz K,Shay JW,Gryaznov SM

更新日期：2002-01-21 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. Germline and somatically acquired ALK aberrations induce increased autophosphorylation, constitutive ALK activation and increased downstream signaling....

journal_title：Oncogene

authors： Carpenter EL,Haglund EA,Mace EM,Deng D,Martinez D,Wood AC,Chow AK,Weiser DA,Belcastro LT,Winter C,Bresler SC,Vigny M,Mazot P,Asgharzadeh S,Seeger RC,Zhao H,Guo R,Christensen JG,Orange JS,Pawel BR,Lemmon MA,Mossé

更新日期：2012-11-15 00:00:00

abstract：:Transforming growth factor beta (TGFβ) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFβ signaling maintains epithelial homeostasis, dysregulated TGFβ signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGFβ sign...

journal_title：Oncogene

authors： White RA,Malkoski SP,Wang XJ

更新日期：2010-10-07 00:00:00

abstract：:The Myc-deregulating chromosomal T(12;15)(Igh-Myc) translocation, the hallmark mutation of inflammation- and interleukin 6-dependent mouse plasmacytoma (PCT), is the premier model of cancer-associated chromosomal translocations because it is the only translocation in mice that occurs spontaneously (B lymphocyte lineag...

journal_title：Oncogene

authors： Takizawa M,Kim JS,Tessarollo L,McNeil N,Waldschmidt TJ,Casellas R,Ried T,Janz S

更新日期：2010-07-15 00:00:00

abstract：:We have established conditions for the immortalization of human fibroblasts by the large T antigen of the rodent virus polyoma. This allows the mechanism of immortalization to be studied, without interference by transformation events, in cells with relatively stable chromosomes. Large T antigen could immortalize human...

journal_title：Oncogene

authors： Strauss M,Hering S,Lubbe L,Griffin BE

更新日期：1990-08-01 00:00:00