Abstract:
:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transcription of great interest. Gene expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated by a viral transcriptional stimulator, Tax. We herein report a novel mechanism of transcription from the HTLV-1 long terminal repeat (LTR) that is regulated by Tax. In this study, we determined that Tax is able to activate transcription from the LTR, even when it was heavily methylated. In addition, the methyl-CpG-binding domain 2 (MBD2) protein played an important role in Tax-mediated transcriptional activation. We demonstrated the importance of a physical interaction between Tax and MBD2 in enhancing the transcriptional activity of Tax against the methylated LTR. Furthermore, we identified the formation of a protein complex composed of MBD2 and Tax bound to the methylated LTR. We propose a new model of epigenetic regulation by MBD2 acting in concert with a virally encoded transactivator, Tax. Our observation provides insight into the epigenetic regulation of gene expression and the diverse mechanisms of transcriptional regulation using methylated promoters.
journal_name
Oncogenejournal_title
Oncogeneauthors
Ego T,Tanaka Y,Shimotohno Kdoi
10.1038/sj.onc.1208394subject
Has Abstractpub_date
2005-03-10 00:00:00pages
1914-23issue
11eissn
0950-9232issn
1476-5594pii
1208394journal_volume
24pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Myogenic transcription is repressed in myoblasts by serum-activated cyclin-dependent kinases, such as cdk2 and cdk4. Serum withdrawal promotes muscle-specific gene expression at least in part by down-regulating the activity of these cdks. Unlike the other cdks, cdk9 is not serum- or cell cycle-regulated and is instead...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205493
更新日期:2002-06-13 00:00:00
abstract::The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.304
更新日期:2014-07-03 00:00:00
abstract::Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunoprecipitation of fusion protein or in vitro translated protein, respect...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201492
更新日期:1997-12-18 00:00:00
abstract::The MAP kinase pathway impinging on ERK2 has been shown to be integrally associated with mitogenic signalling in many cell types. Previously, we and others have demonstrated that oncogenic forms of Raf-1 kinase, when expressed in fibroblasts, lead to the constitutive activation of ERK2, the de-regulation of c-fos expr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-16 00:00:00
abstract::Protein phosphatase inhibitors are often considered as tumor promoters. Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role in tumor development is largely undefined. Here we characterize, for the first time, the functions of PPP1R1A in Ewing sarco...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.378
更新日期:2018-02-08 00:00:00
abstract::Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0665-6
更新日期:2019-05-01 00:00:00
abstract::There is strong evidence at the individual level and the population level that an efficient cytotoxic T lymphocyte (CTL) response to HTLV-1 limits the proviral load and the risk of associated inflammatory diseases such as HAM/TSP. This evidence comes from host population genetics, viral genetics, DNA expression microa...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208970
更新日期:2005-09-05 00:00:00
abstract::Recently, the MLL gene at 11q23 was found to be involved in a subset of leukemias with an 11q23 abnormality. In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::In both humans with long-standing ulcerative colitis and mouse models of colitis-associated carcinogenesis (CAC), tumors develop predominantly in the distal part of the large intestine but the biological basis of this intriguing pathology remains unknown. Herein we report intrinsic differences in gene expression betwe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.307
更新日期:2016-05-12 00:00:00
abstract::An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.264
更新日期:2009-11-12 00:00:00
abstract::The transcript encoding endonuclein, the human homolog of yeast PWP1, was previously found up-regulated in pancreatic cancer tissue. By immunohistochemistry we detected a ubiquitous presence in several tissues examined: skin, liver, thyroid gland, heart muscle, neurons, kidney, bladder, pancreas, adrenal gland, ovary,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205186
更新日期:2002-02-07 00:00:00
abstract::p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.473
更新日期:2015-10-01 00:00:00
abstract::Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203920
更新日期:2000-11-16 00:00:00
abstract::There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well underst...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203057
更新日期:1999-11-18 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.184
更新日期:2016-03-10 00:00:00
abstract::The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. As the activity of many transcription factors is regula...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.484
更新日期:2009-03-05 00:00:00
abstract::Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop resistance to chemotherapies rapidly, whereas the underlying mechanisms are not completely understood. Here we show that genotoxic treatments significantly increas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.189
更新日期:2016-03-10 00:00:00
abstract::The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207298
更新日期:2004-03-04 00:00:00
abstract::Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancies, head and neck cancer, and breast cancer. We have previously demonstrated a high frequency of Stat3 DNA-bind...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204349
更新日期:2001-05-03 00:00:00
abstract::An early event of cell migration is characterized as the rapid reorganization of the actin cytoskeleton. Recently, we have demonstrated that rapamycin inhibits tumor cell motility. To understand the underlying mechanism, this study was set to determine whether rapamycin inhibition of cell motility is related to its pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.137
更新日期:2008-08-28 00:00:00
abstract::Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0506-7
更新日期:2019-02-01 00:00:00
abstract::Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation. TPA treatment has little or no effect on FGF receptor activation but specifically inhibits the activation of p38 MAPK but not other downstream si...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205268
更新日期:2002-03-27 00:00:00
abstract::The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208210
更新日期:2005-04-14 00:00:00
abstract::Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207113
更新日期:2003-11-24 00:00:00
abstract::N-cadherin is a cell-cell adhesion molecule that plays a role in breast cancer metastasis. Here, we show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. Similarly, exogenous expression of N-c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.65
更新日期:2013-01-24 00:00:00
abstract::Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor known to regulate a large number of genes in hepatocytes and pancreatic beta cells. Although HNF4alpha is highly expressed in some sections of the kidney, little is known about its role in this organ and about HNF4alpha-regulated ge...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208794
更新日期:2005-09-22 00:00:00
abstract::Ras is a major signaling molecule activated by interleukin-6. There have been no published reports, however, that specifically examine the kinetics and percentage of Ras activation in response to IL-6. Model cell lines were used to study activation of N- and K-ras induced by IL-6. All of the myeloma cell lines we test...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205387
更新日期:2002-12-12 00:00:00
abstract::Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.220
更新日期:2016-03-24 00:00:00
abstract::Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites to promote tumor growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on tumor...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.128
更新日期:2016-11-17 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0985-1
更新日期:2020-01-01 00:00:00