Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas.

abstract：:Integrin α3β1 regulates adhesive interactions of cells with laminins and have a critical role in adhesion-dependent cellular responses. Here, we examined the role of α3β1-integrin in ErbB2-dependent proliferation of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM). Depletion of α3...

journal_title：Oncogene

authors： Novitskaya V,Romanska H,Kordek R,Potemski P,Kusińska R,Parsons M,Odintsova E,Berditchevski F

更新日期：2014-05-22 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests...

journal_title：Oncogene

authors： van Gijn SE,Wierenga E,van den Tempel N,Kok YP,Heijink AM,Spierings DCJ,Foijer F,van Vugt MATM,Fehrmann RSN

更新日期：2019-02-01 00:00:00

abstract：:There is strong evidence at the individual level and the population level that an efficient cytotoxic T lymphocyte (CTL) response to HTLV-1 limits the proviral load and the risk of associated inflammatory diseases such as HAM/TSP. This evidence comes from host population genetics, viral genetics, DNA expression microa...

journal_title：Oncogene

authors： Bangham CR,Osame M

更新日期：2005-09-05 00:00:00

abstract：:The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...

journal_title：Oncogene

authors： Smith AL,Iwanaga R,Drasin DJ,Micalizzi DS,Vartuli RL,Tan AC,Ford HL

更新日期：2012-12-13 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for the treatment of advanced metastatic tumors. Bisindolylmaleimide alkaloid (B...

journal_title：Oncogene

authors： Li X,Ma H,Li L,Chen Y,Sun X,Dong Z,Liu JY,Zhu W,Zhang JT

更新日期：2018-05-01 00:00:00

abstract：:A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We desc...

journal_title：Oncogene

authors： Morikawa M,Koinuma D,Miyazono K,Heldin CH

更新日期：2013-03-28 00:00:00

abstract：:Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...

journal_title：Oncogene

authors： Pontén F,Berg C,Ahmadian A,Ren ZP,Nistér M,Lundeberg J,Uhlén M,Pontén J

更新日期：1997-08-28 00:00:00

abstract：:Inhibition of telomerase activity by telomerase inhibitors induces a gradual loss of telomeres, and this in turn causes cancer cells to enter to a crisis stage. Here, we report the telomerase inhibitor telomestatin, which is known to stabilize G-quadruplex structures at 3' single-stranded telomeric overhangs (G-tails)...

journal_title：Oncogene

authors： Tahara H,Shin-Ya K,Seimiya H,Yamada H,Tsuruo T,Ide T

更新日期：2006-03-23 00:00:00

abstract：:The growth-suppressive activity of the retinoblastoma (RB) protein is suggested to be regulated by phosphorylation. In studies on the kinase that phosphorylates the RB proteins, we have previously found that RB proteins can be phosphorylated by purified cdc2 kinase. In this study, we noted that RB proteins immunopreci...

journal_title：Oncogene

authors： Kitagawa M,Saitoh S,Ogino H,Okabe T,Matsumoto H,Okuyama A,Tamai K,Ohba Y,Yasuda H,Nishimura S

更新日期：1992-06-01 00:00:00

abstract：:The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino a...

journal_title：Oncogene

authors： Tamagnone L,Partanen J,Armstrong E,Lasota J,Ohgami K,Tazunoki T,LaForgia S,Huebner K,Alitalo K

更新日期：1993-07-01 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recu...

journal_title：Oncogene

authors： Özeş AR,Miller DF,Özeş ON,Fang F,Liu Y,Matei D,Huang T,Nephew KP

更新日期：2016-10-13 00:00:00

abstract：:Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas af...

journal_title：Oncogene

authors： Wang Y,Sugiyama H,Axelson H,Panda CK,Babonits M,Ma A,Steinberg JM,Alt FW,Klein G,Wiener F

更新日期：1992-06-01 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) is a transcriptional coactivator for nuclear receptors and other transcription factors. AIB1 has an important role in malignancy of several cancers such as breast and prostate cancers. However, its involvement in human hepatocellular carcinoma (HCC) progression remains unclear. Here...

journal_title：Oncogene

authors： Xu Y,Chen Q,Li W,Su X,Chen T,Liu Y,Zhao Y,Yu C

更新日期：2010-06-10 00:00:00

abstract：:A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains to be elucidated. I...

journal_title：Oncogene

authors： Yao R,Natsume Y,Noda T

更新日期：2004-08-12 00:00:00

abstract：:Targeted expression of transgenes is essential for the accurate representation of human disease in in vivo models. Current approaches to generate conditional transgenic mouse models are cumbersome and not amenable to high-throughput analysis since they require de novo generation and characterization of genetically mod...

journal_title：Oncogene

authors： Shoumariyeh K,Schneider N,Poggio T,Veratti P,Ehrenfeld S,Redhaber DM,Khan R,Pfeifer D,Klingeberg C,Kreutmair S,Rudelius M,Quintanilla-Martinez L,Fend F,Illert AL,Duyster J,Miething C

更新日期：2020-02-01 00:00:00

abstract：:Reexpression of hypermethylated tumor suppressor genes using DNA methyltransferase (DNMT) and histone deacetylase inhibitors occurs by a mechanism whereby promoter demethylation is the dominant event. In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promot...

journal_title：Oncogene

authors： Lakshmikuttyamma A,Scott SA,DeCoteau JF,Geyer CR

更新日期：2010-01-28 00:00:00

abstract：:Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has to be elucidated. We have determined that human colon tumors exhibit decreased levels of mature let-7 isoforms and increased ex...

journal_title：Oncogene

authors： King CE,Wang L,Winograd R,Madison BB,Mongroo PS,Johnstone CN,Rustgi AK

更新日期：2011-10-06 00:00:00

abstract：:Rel/NF-kappaB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of biological factors and environmental conditions can lead to the activation of Rel/NF-kappaB dimers by signaling degradation ...

journal_title：Oncogene

authors： Chen FE,Ghosh G

更新日期：1999-11-22 00:00:00

abstract：:We studied loss of heterozygosity (LOH) in chromosome 7q in order to determine the location of a putative tumor suppressor gene (TSG) in human epithelial ovarian carcinomas. Samples were obtained from 26 primary ovarian carcinomas at the time of staging laparotomy. Paired normal and tumoral DNAs were used as templates...

journal_title：Oncogene

authors： Zenklusen JC,Weitzel JN,Ball HG,Conti CJ

更新日期：1995-07-20 00:00:00

abstract：:Inhibitor of growth (ING)4, member of a gene family encoding potential tumor suppressors, is implicated as a repressor of angiogenesis and tumor growth and suppresses loss of contact inhibition in vitro. Here, we report that ING4 undergoes alternative splicing. Expression analysis identified novel ING4 spliced variant...

journal_title：Oncogene

authors： Raho G,Miranda C,Tamborini E,Pierotti MA,Greco A

更新日期：2007-08-09 00:00:00

abstract：:Previous work has demonstrated that E2F proteins regulate the expression of various genes encoding proteins essential for DNA replication and cell-cycle progression. E2F1 in particular is required for the initial entry to the cell cycle from a quiescent state and is required for the activation of other E2F genes. Othe...

journal_title：Oncogene

authors： Leung JY,Ehmann GL,Giangrande PH,Nevins JR

更新日期：2008-07-10 00:00:00

abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

journal_title：Oncogene

authors： Eichele K,Ramer R,Hinz B

更新日期：2008-05-08 00:00:00

abstract：:Fos-related antigen-1 (Fra-1) is a member of the Activator Protein-1 (AP-1) transcription factor superfamily that is overexpressed in a variety of cancers, including colon, breast, lung, bladder and brain. High Fra-1 levels are associated with enhanced cell proliferation, survival, migration and invasion. Despite its ...

journal_title：Oncogene

authors： Pakay JL,Diesch J,Gilan O,Yip YY,Sayan E,Kolch W,Mariadason JM,Hannan RD,Tulchinsky E,Dhillon AS

更新日期：2012-04-05 00:00:00

abstract：:The p53 tumor suppressor protein plays a critical role in mediating cellular response to stress. Upon DNA damage, post-translational modifications stabilize and activate this nuclear phosphoprotein. To determine the effect of phosphorylation site mutants in the context of the whole p53 protein, we performed reporter a...

journal_title：Oncogene

authors： Dohoney KM,Guillerm C,Whiteford C,Elbi C,Lambert PF,Hager GL,Brady JN

更新日期：2004-01-08 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...

journal_title：Oncogene

authors： Mendelsohn J,Baselga J

更新日期：2000-12-27 00:00:00

abstract：:Retinoids have been shown to inhibit the growth of a number of human tumor cells, including several ovarian adenocarcinoma cell lines. All-trans retinoic acid (RA) is an effective growth suppressor of CA-OV3 cells but not SK-OV3 cells. Since the effects of RA are known to be mediated via the nuclear receptors (RARs an...

journal_title：Oncogene

authors： Wu S,Zhang D,Zhang ZP,Soprano DR,Soprano KJ

更新日期：1998-12-03 00:00:00

abstract：:The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a reversal of methylation states. CpG island associated genes, in particular tumour suppressor or rel...

journal_title：Oncogene

authors： Clark SJ,Melki J

更新日期：2002-08-12 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00