Abstract:
:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in relation to transcriptional regulation and in particular how this impacts upon cell cycle control. We will (i) describe the structure of BRCA1 and how it may contribute to its transcription function; (ii) describe the interaction of BRCA1 with the core transcriptional machinery (RNA polII); (iii) describe how BRCA1 may regulate transcription at an epigenetic level through chromatin modification; (iv) discuss the role of BRCA1 in modulating transcription through its association with sequence-specific transcription factors. Finally, we will discuss the possible effects of BRCA1 transcriptional regulation on downstream targets with known roles in cell cycle control.
journal_name
Oncogenejournal_title
Oncogeneauthors
Mullan PB,Quinn JE,Harkin DPdoi
10.1038/sj.onc.1209872subject
Has Abstractpub_date
2006-09-25 00:00:00pages
5854-63issue
43eissn
0950-9232issn
1476-5594pii
1209872journal_volume
25pub_type
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