p53 represses SV40 transcription by preventing formation of transcription complexes.

abstract：:The eph gene encodes a putative receptor tyrosine kinase for an as yet unknown ligand. Some human cancer cells have been found to overexpress eph mRNAs without gene amplification. We show here that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repe...

journal_title：Oncogene

authors： Maru Y,Hirai H,Takaku F

更新日期：1990-03-01 00:00:00

abstract：:We have examined the mitogenic potential of platelet-derived growth factor (PDGF) on AIDS (acquired immune deficiency syndrome)-related and sporadic Kaposi's sarcoma cells in comparison to fibroblasts at physiological and subphysiological calcium concentrations of the culture medium. At low calcium concentrations in t...

journal_title：Oncogene

authors： Roth WK,Werner S,Schirren CG,Hofschneider PH

更新日期：1989-04-01 00:00:00

abstract：:Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...

journal_title：Oncogene

authors： Cao Y,Marks JW,Liu Z,Cheung LH,Hittelman WN,Rosenblum MG

更新日期：2014-01-23 00:00:00

abstract：:p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...

journal_title：Oncogene

authors： Veeramani S,Igawa T,Yuan TC,Lin FF,Lee MS,Lin JS,Johansson SL,Lin MF

更新日期：2005-11-03 00:00:00

abstract：:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently...

journal_title：Oncogene

authors： Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OA

更新日期：1998-06-04 00:00:00

abstract：:Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...

journal_title：Oncogene

authors： Liang W,Miao S,Zhang B,He S,Shou C,Manivel P,Krishna R,Chen Y,Shi YE

更新日期：2015-04-30 00:00:00

abstract：:Transcription from the rat transforming growth factor alpha (TGF-alpha) promoter initiates at multiple sites within a 200-bp G+C-rich region that lacks TATA and CAAT motifs but contains multiple potential binding sites for the transcription factor Sp1. In the present study, we used deletion analysis to establish the 5...

journal_title：Oncogene

authors： Chen X,Azizkhan JC,Lee DC

更新日期：1992-09-01 00:00:00

abstract：:By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one a...

journal_title：Oncogene

authors： Duh FM,Scherer SW,Tsui LC,Lerman MI,Zbar B,Schmidt L

更新日期：1997-09-25 00:00:00

abstract：:We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently, and that tyrosine kinase activity of the NGF receptor is essential for the activation of Ras (Muroya et a...

journal_title：Oncogene

authors： Hashimoto Y,Matuoka K,Takenawa T,Muroya K,Hattori S,Nakamura S

更新日期：1994-03-01 00:00:00

abstract：:FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES i...

journal_title：Oncogene

authors： Yates KE,Lynch MR,Wong SG,Slamon DJ,Gasson JC

更新日期：1995-03-16 00:00:00

abstract：:Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-associated polo-like ki...

journal_title：Oncogene

authors： Holtrich U,Wolf G,Yuan J,Bereiter-Hahn J,Karn T,Weiler M,Kauselmann G,Rehli M,Andreesen R,Kaufmann M,Kuhl D,Strebhardt K

更新日期：2000-10-05 00:00:00

abstract：:Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determi...

journal_title：Oncogene

authors： Iliakis G,Wang Y,Guan J,Wang H

更新日期：2003-09-01 00:00:00

abstract：:14-3-3sigma proteins regulate numerous cellular processes that are important to cancer development. One of its biological roles involves G2 cell-cycle arrest following DNA damage. It has also been reported that the loss of 14-3-3sigma expression via CpG methylation may contribute to malignant transformation by impairi...

journal_title：Oncogene

authors： Pulukuri SM,Rao JS

更新日期：2006-08-03 00:00:00

abstract：:NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary models has accentuated the need for definitions of the mammary lesions in genetically engineered mice (GEM) and to assess their usefulness as models of human breast...

journal_title：Oncogene

authors： Cardiff RD,Anver MR,Gusterson BA,Hennighausen L,Jensen RA,Merino MJ,Rehm S,Russo J,Tavassoli FA,Wakefield LM,Ward JM,Green JE

更新日期：2000-02-21 00:00:00

abstract：:NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia. We identified a novel fusion between NUP98 and IQ motif containing G (IQCG) gene from a de novo acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29). IQCG has two putative coiled-coil domains and one IQ domain. T...

journal_title：Oncogene

authors： Pan Q,Zhu YJ,Gu BW,Cai X,Bai XT,Yun HY,Zhu J,Chen B,Weng L,Chen Z,Xue YQ,Chen SJ

更新日期：2008-05-29 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...

journal_title：Oncogene

authors： Totzke G,Schulze-Osthoff K,Jänicke RU

更新日期：2003-09-11 00:00:00

abstract：:Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes coupled with a class prediction model could be used to define subgroups of hig...

journal_title：Oncogene

authors： Yamanaka R,Arao T,Yajima N,Tsuchiya N,Homma J,Tanaka R,Sano M,Oide A,Sekijima M,Nishio K

更新日期：2006-09-28 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase family member. BS cells exhibit genomic instability, including excessive homologous recombination and chromosomal aberrations. We reported previously that BS c...

journal_title：Oncogene

authors： Rassool FV,North PS,Mufti GJ,Hickson ID

更新日期：2003-11-27 00:00:00

abstract：:Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing t...

journal_title：Oncogene

authors： Gu P,Wang Y,Bisht KK,Wu L,Kukova L,Smith EM,Xiao Y,Bailey SM,Lei M,Nandakumar J,Chang S

更新日期：2017-04-06 00:00:00

abstract：:Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal tissue is an important clinical goal. Due to their sequence-derived specificity and properties as gene regulators in IR-affected pathways, microRNAs (miRNAs) coul...

journal_title：Oncogene

authors： Metheetrairut C,Adams BD,Nallur S,Weidhaas JB,Slack FJ

更新日期：2017-01-26 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...

journal_title：Oncogene

authors： Murillo MM,del Castillo G,Sánchez A,Fernández M,Fabregat I

更新日期：2005-06-30 00:00:00

abstract：:Reexpression of hypermethylated tumor suppressor genes using DNA methyltransferase (DNMT) and histone deacetylase inhibitors occurs by a mechanism whereby promoter demethylation is the dominant event. In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promot...

journal_title：Oncogene

authors： Lakshmikuttyamma A,Scott SA,DeCoteau JF,Geyer CR

更新日期：2010-01-28 00:00:00

abstract：:In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...

journal_title：Oncogene

authors： Fabris L,Berton S,Citron F,D'Andrea S,Segatto I,Nicoloso MS,Massarut S,Armenia J,Zafarana G,Rossi S,Ivan C,Perin T,Vaidya JS,Avanzo M,Roncadin M,Schiappacassi M,Bristow RG,Calin G,Baldassarre G,Belletti B

更新日期：2016-09-15 00:00:00

abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

journal_title：Oncogene

authors： Kim H,You S,Farris J,Foster LK,Foster DN

更新日期：2001-05-31 00:00:00

abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...

journal_title：Oncogene

authors： Ling LS,Voskas D,Woodgett JR

更新日期：2013-11-21 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:Genetic mutations of oncogenes often underlie deranged cell growth and altered differentiation pathways leading to malignant transformation of B-lymphocytes. However, addiction to oncogenes is not the only drive to lymphoid tumor pathogenesis. Dependence on non-oncogenes, which act by propelling basic mechanisms of ce...

journal_title：Oncogene

authors： Mandato E,Manni S,Zaffino F,Semenzato G,Piazza F

更新日期：2016-11-24 00:00:00

abstract：:In contrast to the hereditary form of medullary thyroid carcinoma (MTC), little is known about the etiology of sporadic MTC. Somatic gain-of-function mutations in the RET proto-oncogene, encoding a receptor tyrosine kinase, are found in an average of 40% of sporadic MTC. We analysed 31 sporadic MTC for somatic and ger...

journal_title：Oncogene

authors： Gimm O,Dziema H,Brown J,Hoang-Vu C,Hinze R,Dralle H,Mulligan LM,Eng C

更新日期：2001-04-19 00:00:00

abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

journal_title：Oncogene

authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

更新日期：1999-11-04 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00